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Toxins 2013, 5(6), 1180-1201; doi:10.3390/toxins5061180
Review

Heparin-Binding Epidermal Growth Factor-like Growth Factor/Diphtheria Toxin Receptor in Normal and Neoplastic Hematopoiesis

*  and
Department of Medicine, Section of Hematology, Cancer Research & Cell Biology Laboratory, University of Verona, Verona, Italy
* Author to whom correspondence should be addressed.
Received: 9 May 2013 / Revised: 5 June 2013 / Accepted: 13 June 2013 / Published: 18 June 2013
(This article belongs to the Special Issue Diphtheria Toxin)
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Abstract

Heparin-binding EGF-like growth factor (HB-EGF) belongs to the EGF family of growth factors. It is biologically active either as a molecule anchored to the membrane or as a soluble form released by proteolytic cleavage of the extracellular domain. HB-EGF is involved in relevant physiological and pathological processes spanning from proliferation and apoptosis to morphogenesis. We outline here the main activities of HB-EGF in connection with normal or neoplastic differentiative or proliferative events taking place primitively in the hematopoietic microenvironment.
Keywords: HB-EGF; GPCR; EGFR/ErbB/HER; Hematopoiesis; Leukemia; Myeloma HB-EGF; GPCR; EGFR/ErbB/HER; Hematopoiesis; Leukemia; Myeloma
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Vinante, F.; Rigo, A. Heparin-Binding Epidermal Growth Factor-like Growth Factor/Diphtheria Toxin Receptor in Normal and Neoplastic Hematopoiesis. Toxins 2013, 5, 1180-1201.

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