Next Article in Journal
Freeform Fabrication of Magnetophotonic Crystals with Diamond Lattices of Oxide and Metallic Glasses for Terahertz Wave Control by Micro Patterning Stereolithography and Low Temperature Sintering
Next Article in Special Issue
Active and Precise Control of Microdroplet Division Using Horizontal Pneumatic Valves in Bifurcating Microchannel
Previous Article in Journal
Photomechanical Bending of Azobenzene-Based Photochromic Molecular Fibers
Previous Article in Special Issue
Tunable Sensor Response by Voltage-Control in Biomimetic Hair Flow Sensors
Article Menu

Export Article

Open AccessArticle
Micromachines 2013, 4(2), 138-148; doi:10.3390/mi4020138

Pushing the Limits of Electrical Detection of Ultralow Flows in Nanofluidic Channels

MESA+ Institute for Nanotechnology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 11 December 2012 / Revised: 30 January 2013 / Accepted: 20 March 2013 / Published: 2 April 2013
View Full-Text   |   Download PDF [1223 KB, uploaded 2 April 2013]   |  

Abstract

This paper presents improvements in flow detection by electrical cross-correlation spectroscopy. This new technique detects molecular number fluctuations of electrochemically active analyte molecules as they are transported by liquid flow through a nanochannel. The fluctuations are used as a marker of liquid flow as their time of flight in between two consecutive transducers is determined, thereby allowing for the measurement of liquid flow rates in the picoliter-per-minute regime. Here we show an enhanced record-low sensitivity below 1 pL/min by capitalizing on improved electrical instrumentation, an optimized sensor geometry and a smaller channel cross section. We further discuss the impact of sensor geometry on the cross-correlation functions.
Keywords: flow detection; electrochemical sensor; nanofluidics; cross-correlation; nanochannel; redox cycling flow detection; electrochemical sensor; nanofluidics; cross-correlation; nanochannel; redox cycling
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mathwig, K.; Lemay, S.G. Pushing the Limits of Electrical Detection of Ultralow Flows in Nanofluidic Channels. Micromachines 2013, 4, 138-148.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Micromachines EISSN 2072-666X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top