Next Article in Journal
Succinate Dehydrogenase B Subunit Immunohistochemical Expression Predicts Aggressiveness in Well Differentiated Neuroendocrine Tumors of the Ileum
Next Article in Special Issue
Estrogen Signaling in Lung Cancer: An Opportunity for Novel Therapy
Previous Article in Journal
Neuroendocrine Tumors of the Lung
Article Menu

Export Article

Open AccessReview
Cancers 2012, 4(3), 799-807; doi:10.3390/cancers4030799

Endometrial Serous Carcinoma: Its Molecular Characteristics and Histology-Specific Treatment Strategies

1
Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan
2
Department of Biochemistry, Shimane University School of Medicine, Izumo 6938501, Japan
*
Author to whom correspondence should be addressed.
Received: 4 June 2012 / Revised: 28 July 2012 / Accepted: 1 August 2012 / Published: 7 August 2012
(This article belongs to the Special Issue Hormones and Carcinogenesis)
View Full-Text   |   Download PDF [933 KB, uploaded 7 August 2012]   |  

Abstract

Endometrial cancer is the fourth most common malignancy in women, with most cases being classified as early stage endometrioid tumors that carry a favorable prognosis. The endometrial serous histological subtype (ESC), however, while only accounting for 10% of all endometrial cancers is responsible for a disproportionate number of deaths. Unlike the estrogen-dependent, well differentiated endometrioid tumors, which are commonly associated with a younger age of onset, ESCs are estrogen-independent and tend to present at an advanced stage and in older women. Treatment for ESC entails aggressive surgery and multimodal adjuvant therapy. In this review, we describe the clinical behavior, molecular aspects, and treatment strategies for ESC.
Keywords: endometrial serous carcinoma; endometrial carcinoma; Type II endometrial carcinoma; estrogen independent endometrial serous carcinoma; endometrial carcinoma; Type II endometrial carcinoma; estrogen independent
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Nakayama, K.; Nakayama, N.; Ishikawa, M.; Miyazaki, K. Endometrial Serous Carcinoma: Its Molecular Characteristics and Histology-Specific Treatment Strategies. Cancers 2012, 4, 799-807.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top