Table of Contents
Cancers, Volume 9, Issue 3 (March 2017)
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Cover Story (view full-size image) The progression of prostate cancer (PC) is influenced by androgens and the androgen receptor (AR). [...] Read more. The progression of prostate cancer (PC) is influenced by androgens and the androgen receptor (AR). PC develops resistance to low testosterone levels called castration-resistant PC (CRPC). Surprisingly, the AR signaling pathway are still activated by some of the AR collaborative transcription factors (TFs) in most CRPC cases. Therefore, elucidating the crosstalk between the AR and collaborative TFs on the AR pathway is critical for developing new strategies for the treatment of CRPC. We summarize the AR signaling pathways in terms of collaborative TFs and focus on pyrrole-imidazole polyamides as candidate compounds for the treatment of PC. View the paper