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Article

A Review on Green Synthesis of TiO2 NPs: Photocatalysis and Antimicrobial Applications

by
Vishal Verma
1,
Mawaheb Al-Dossari
2,3,
Jagpreet Singh
4,5,*,
Mohit Rawat
1,†,
Mohamed G. M. Kordy
6,7 and
Mohamed Shaban
6,8
1
Department of Nanotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib 140406, India
2
Department of Physics, Dhahran Aljanoub, King Khalid University, Abha 61421, Saudi Arabia
3
Research Center for Advanced Materials Science (RCAMS), King Khalid University, Abha 61413, Saudi Arabia
4
Department of Chemical Engineering, Chandigarh University, Gharuan, Mohali 140413, India
5
Centre for Research and Development, Chandigarh University, Gharuan, Mohali 140413, India
6
Nanophotonics and Applications (NPA) Lab, Physics Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt
7
Biochemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt
8
Department of Physics, Faculty of Science, Islamic University of Madinah, Al-Madinah Al-Munawarah 42351, Saudi Arabia
*
Author to whom correspondence should be addressed.
†
Deceased author.
Polymers 2022, 14(7), 1444; https://doi.org/10.3390/polym14071444
Submission received: 6 March 2022 / Revised: 21 March 2022 / Accepted: 25 March 2022 / Published: 1 April 2022
(This article belongs to the Section Polymer Applications)
Browse Figures
Versions Notes

Abstract

:
Nanotechnology is a fast-expanding area with a wide range of applications in science, engineering, health, pharmacy, and other fields. Nanoparticles (NPs) are frequently prepared via a variety of physical and chemical processes. Simpler, sustainable, and cost-effective green synthesis technologies have recently been developed. The synthesis of titanium dioxide nanoparticles (TiO2 NPs) in a green/sustainable manner has gotten a lot of interest in the previous quarter. Bioactive components present in organisms such as plants and bacteria facilitate the bio-reduction and capping processes. The biogenic synthesis of TiO2 NPs, as well as the different synthesis methods and mechanistic perspectives, are discussed in this review. A range of natural reducing agents including proteins, enzymes, phytochemicals, and others, are involved in the synthesis of TiO2 NPs. The physics of antibacterial and photocatalysis applications were also thoroughly discussed. Finally, we provide an overview of current research and future concerns in biologically mediated TiO2 nanostructures-based feasible platforms for industrial applications.

1. Introduction

Nanotechnology deals with atoms and molecules at the supermolecule scale [1,2]. Due to the escalating surface area to volume, there is a drastic change in the physicochemical characteristics of nanomaterials at this level [3]. Along with its size, structure, and physicochemical and biological characteristics, nanotechnology has a diverse set of applications in a multitude of fields such as industries, notably mechanical, electronic, imaging specific targeting, and molecular diagnosis [4]. Nanoparticles (NPs) are being used in more and more purposes every day, covering medical, cosmetology, pharmaceuticals, and power. Organic and inorganic NPs are the two basic types of NPs. Micelles, liposomes, chitosan, ferritin, dendrimers, and other organic NPs are examples. Inorganic NPs are divided into three groups: metal nanoparticles; semiconductor NPs; and magnetic NPs [5].
Due to their intriguing thermal, optical, electrical, and magnetic characteristics, metal oxide nanoparticles, particularly TiO2 nanoparticles, are widely employed. Titania is the only titanium oxide that occurs naturally [6,7,8,9]. TiO2 is an odorless, brilliantly white powder that, under normal conditions, is hydrophobic in nature. It is a highly stable material that also works well as an opacifier. As a result of its key properties, like minimal cost, great oxidizing strength, high chemical stability, high refractive index, and the existence of oxygen-containing functional groups in its lattice, TiO2 NPs are largely employed as a semiconductor material. In 2011, global TiO2 output surpassed 10,000 tons per year [10]. They can also be employed to biodegrade a variety of microorganisms, including bacteria, viruses, and cancer cells. UV light resistant oxides, toothpastes, papers, food colorants, paints, plastics, and inks all contain them. TiO2 NPs are the most efficient solar collectors, absorbing 3–4% of solar energy. As a result, they are well-known photocatalysts for hydrogen production, as well as for the degradation of hazardous chemical compounds in water [11]. Surface properties and topologies of TiO2 NPs are distinct. TiO2 is a whitish metal oxide that is a solid inert compound. Anatase, rutile, and brookite are the three distinct polymorphs found in TiO2 NPs. Anatase and rutile have similar qualities (such as gloss, rigidity, and densities) and geometric symmetry (tetragonal) [12]. TiO2 is an insoluble, fire-resistant, high thermal stability metal oxide that is not categorized as dangerous. The atomic number of titanium in TiO2 is 22 from the IV B group, whereas the atomic number of oxygen is eight from the VI A group [1]. It also has good characteristics including hydrophobic nature and a wide bandgap. Dye-sensitized solar cells, self-cleaning, photocatalysis, charge-spreading devices, chemical sensors, microelectronics, electrochemistry, antimicrobial products, and textiles are all examples of industrial applications [13]. Degradation of harmful compounds is based on the catalytic oxidation of hydrocarbons [14,15,16,17,18]. TiO2 NPs are likely the most significant scientific interest across all metal oxides in photocatalytic, antimicrobial, and antibacterial effective applications due to their superior properties [19,20,21]. The use of nano-sized TiO2 in photocatalytic wastewater treatment is a very successful method for decomposing and eliminating resistant organic and inorganic contaminants in wastewater [22,23,24].
Chemical vapor deposition (CVD), electrochemical deposition, sol-gel technique, hydrothermal crystallization, and chemical precipitation are the most common ways of making TiO2 NPs. [25]. All of the processes listed above are time and money-intensive, and they all require high temperatures, pressures, and harmful chemicals to complete, limiting their manufacturing and potential medicinal applications [26]. Consequently, green synthesis is a frequently used process for the production of NPs. Green synthesis is a naturally adaptable, environmentally sound, and cost-effective technique for large–scale NP synthesis [27,28]. Plant extracts operate as reducing agents, and the same reducing agent can be employed to make a variety of metallic nanoparticles [29,30,31,32,33]. Plant extracts that are used in the synthesis of NPs can be leaves, roots, fruits, seeds, or beans [27,34,35,36,37]. Green TiO2 nanoparticles are prepared using several extracts for multifunctional applications. Plant-based nanoparticles could be valuable in a variety of industries, including medicinal, food, catalysis, and cosmetics. According to previous findings, green sources are always utilized as a stabilizer and reducing agent in the production of NPs with structured shape and size.
The current review focuses on plant and microorganism-based green synthesis of TiO2 NPs, including detailed methods and practical applications. To begin, the green synthesis of numerous biological extracts has been thoroughly addressed. Second, using an in-depth characterization investigation on green synthesized TiO2 NPs, a comprehensive examination of the morphological and structural characteristics of NPs is explored. Finally, the benefits of green synthesis, particularly for photocatalysis and antimicrobial applications, are also discussed. Finally, the conclusion and future outlook have been discussed. We also gathered paper publishing data from PubMed (Figure 1), which shows that academics are increasingly interested in green synthesis of TiO2 NPs.

2. Synthesis of TiO2 NPs by Different Methods

The two primary methodologies for the synthesis of nanomaterials are top-down and bottom-up approaches as shown in Figure 2.
  • Top-down: size reduction from bulk materials
  • Bottom-up: material synthesis from the atomic level

2.1. Top-Down Approach

Bulk material is turned into a nano product using a top-down technique. For size reduction, both physical and chemical approaches were applied. Sputtering, pulse wire discharge, physical milling/ball milling, etching, evaporation–condensation reaction, pulse laser ablation, and lithography are some of the processes employed in the top-down approach. However, there are certain disadvantages to the top-down approach, the most significant of which is that defects are imposed on the product’s surface. This could affect the product’s surface properties and other physical characteristics [38].

2.2. Bottom-Up Approach

The materials were built up from the bottom in the bottom-up approach: atom by atom, molecule by molecule, and cluster by cluster. Most nanostructures with the potential to make a homogeneity, size, and morphology are synthesized using this process. Chemical synthesis is offering a broad range of techniques like chemical vapor deposition, solvothermal, polymer condensation, sol-gel method, aerosol methodology, electrochemistry, pyrolysis, thermal decomposition, frameworks, plasma, and spinning also available Green synthesis, in particular, controlling the process in the bottom-up synthesis to decrease particle development. As a result, scientists can state that the bottom-up technique is crucial in the creation of nanostructures and nanomaterials [39,40,41]. Almost all of these nanomaterial synthesis methods are employed, however, if we consider that, the bottom-up approach is the most efficient as it is beneficial and achieves perfection at the atomic scale. The bottom-up technique is also used since the green synthesis routes have been thought-out to be a practical strategy due to the employment of non–toxic, cost-effective, and ecologically friendly matter [42,43]. Natural various plant extracts are employed in green synthesis. In green chemistry, the plant extract serves as a capping and reducing agent, and it is blended with a simple precursor salt [44]. The plant extract’s phytochemicals can then reduce and stabilize the nanomaterials. With the new revolution, a lot of work has been done in green synthesis to synthesize a variety of metal NPs such as Cu, Pt, Pb, Ag, Au, Zn, and so on [45]. Phyto-synthesis of TiO2 NPs utilizing various plant extracts is discussed in this review. In this regard, recent research has been compiled from the literature to summarize research efforts [45].

2.3. Green Synthesis

Green synthesis is considered to play a key role in the current engineering and science field. As a result of their distinctive properties of biosynthesized nanomaterials, which are used for the treatment of water and contaminated sites [45]. Nanoparticles are of keen interest due to their special attributes, such as their exceedingly small size, high surface area to volume ratio, surface modifiability, and size-dependent properties [14,27]. These nanoparticles also showed their applications in the medical field and pharmacy [38]. Nowadays, vast research is being conducted on the biological system. The biological synthesis of nanomaterials used bacteria, fungi, yeast, and plants. Due to their cost-effectiveness, these synthesis approaches have been the subject of widespread interest. The biologically synthesized nanoparticles have a wide range of applications in the field of contaminant remediation, as well as antibacterial, antifungal, high catalytic, and photochemical activity [45]. Au and Ag NPs are two of the most widely produced NPs, with numerous biomedical applications. The photocatalytic activity of Au and Ag nanoparticles was good. Nanotechnology and biotechnology, which deal with microorganisms like bacteria, fungi, yeasts, algae, and plants, are the most promising fields of research. The use of microorganisms to synthesize nanoparticles revealed a prospective mechanism. The inorganic nanomaterials were produced with the help of the above-mentioned living organisms, and they showed great results. Solubility plays an important role in the resistance, which is caused by the bacterial cell for reactive ions [46,47]. The rate of synthesis of NPs with microbes is very slow and there are limited methods, by which NPs are fabricated with desirable shape and size. The nanomaterials that are routed by plants are cost-effective and very simple methods. In these methods, there is no need for high temperature and toxic chemicals, or high pressure. As a result, these methods are environmentally friendly. Today’s focus was on green synthesis, and with the help of plants, the NPs were very stable and in the proper form and size. Another benefit of green synthesis is that the chance of contamination is quite minimal. The plants contain many phytochemicals, which help in the production of nanomaterials and NPs. Plants provide a variety of phytochemicals that are commonly utilized and inexpensive in the synthesis of nanomaterials and nanoparticles. The phytochemicals also play an important role as they help at the time of photocatalytic activity applications. They help in the oxidation and reduction reactions at the photocatalytic activity time of the organic dyes.

2.4. Plant-Based synthesis of Titanium Dioxide NPs

The green synthesis studies have been achieved on extracts of leaves as plant extract contains a rich source of metabolites. Figure 3 shows schematic diagram of the preparation process of nanoparticles via plant extract. Kashale et al. used Cicer arietinum L. extract to mediate TiO2 NPs in 2016 using TiCl4 (titanium tetrachloride) as a precursor [48]. They have reported that the prepared biosynthesized TiO2 (Bio–TiO2) NPs is a worthy way for the rapid synthesis of NPs. The morphology of Bio–TiO2 NPs showed a crystal structure and other properties were investigated by Raman spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA), transmission electron microscopy (TEM), and BET surface area measurement system. Rao et al. in 2015 obtained the TiO2 NPs by employing the leaf extract of Aloe Vera. Aloe Vera plant is the oldest herbal medicinal plant that contains mineral amino acids and fatty acids and high vitamins. It is also used for skin and hair. The SEM images indicated that the synthesized NPs were showing irregular particle structure and the size was ranging from 60–80 nm. TEM revealed that the shape and structure arrangement were crystalline in nature [49]. The biogenesis of rutile TiO2 NPs was produced utilizing an aqueous extract of Annona squamosa fruit peel. The green synthesis of rutile TiO2 NPs using agricultural waste is a simple, quick, ecologically sustainable, and less expensive process. In TEM, rutile TiO2 NPs have spherical forms and sizes ranging from 23 ± 2 nm. This study also includes SEM, UV, XRD, and EDS examinations. The powder particles have slight agglomeration, as evidenced by the SEM by the closed view of the spherical nanoparticles. The UV–Vis spectrophotometer revealed that TiO2 NPs resulted in a rapid, having a surface plasmon resonance at 284 nm. The XRD data revealed the relevant results to the JCPDS data (File No. 99-101-0954) [50]. In 2016, Madadi and Lotfabad synthesized TiO2 NPs by employing Acanthophyllum laxiusculum aqueous extract. This procedure of synthesizing nanomaterials is green or eco–friendly. The plant genus Acanthophyllum contains the richest sources of triterpene glycosides (saponins). TiO2 NPs are synthesized with the Sol-gel method. The sol-gel method is a common method for the synthesis of titanium dioxide NPs. In the sol-gel process, two steps occur: (1) hydrolysis of the Ti precursor in acidic or basic mediums; and (2) polycondensation of the hydrolyzed products [51]. This polycondensation can be prevented by using a surfactant such as natural surface-active compounds (NSAC) such as those that are utilized in this paper. This results in the formation of a collaborative framework, in which TiO2 NPs can be maintained. Scanning Electron Microscopy (SEM), TEM, UV, Energy Dispersive X–rays (EDAX), XRD, and were used to analyze TiO2 NPs. In this report, SEM images show particle sizes ranging from 20–25 nm, and TEM confirmed SEM data. The UV spectrum revealed an absorption band at 350 nm that corresponds to the optical band gap of 3.5 eV. Eventually, the FTIR confirmed the presence of TiO2 in the sample by peaks at 457, 470 cm−1, which revealed O—Ti—O bonding in anatase morphology. The relevant results of XRD data were found to be similar to JCPDS (File No. 21-1272) [35]. Furthermore, extract of Psidium guajava was used for the preparation of TiO2 NPs by Santhoshkumar et al. in 2014. The Synthesized TiO2 NPs were tested by disc diffusion method against human pathogenic bacteria. The XRD test revealed a dominant peak at 2θ = 27.57° and 41.37°, respectively, indicating the (110) crystallographic plane of anatase and (111) rutile form of TiO2 NPs. Peaks in the FTIR spectra of produced TiO2 NPs are 3410 cm−1 for C–H alkynes, 1578 cm−1, 1451 cm−1 for alkanes, and 1123 cm−1 for C–O absorption. FESEM was used to study the morphological characteristics of produced TiO2 NPs, which revealed a spherical shape and aggregates with an average size of 32.58 nm. Extracellular organic components are adsorbed on the surface of metallic nanoparticles, as evidenced by the presence of carbon, oxygen, magnesium, and chlorine, which were observed in EDX analysis [52]. In 2012, the TiO2 NPs were prepared using an aqueous extract of Jatropha curcas L by Hudlikar et al. XRD, Selected Area Electron Diffraction (SAED), TEM, EDAX, and FTIR spectroscopy were used to characterize the TiO2 NPs samples. The average size of TiO2 NPs was found to be in the range of 25–100 nm. XRD results were in agreement with JCPDS (File no. 84-1285) and TiO2 were nanocrystalline in nature and that was fair with TEM analysis. SAED confirmed the XRD concentric Scherrer planes of TiO2 NPs. The FTIR revealed the nature of the capping agent might be a peptide. This is due to the presence of C–H stretch, (N–H) stretch and carbonyl (–C–O–C–) or (–C–O–) stretch vibrations in the amide II and III bonding, before treatment of latex capped TiO2 NPs with 1% sodium dodecyl sulfate [53]. In 2016, Hunagund et al. employed the hydrothermal approach to synthesize TiO2 NPs with the support of a novel biogenic source, Piper betel leaf extract, and a chromogenic source, nitric acid, which acts as capping and reducing agents. Various characterization techniques were used on the synthesized TiO2 NPs, including UV–vis spectrophotometry, XRD, FTIR, TEM, which revealed that the NPs were spherical in shape with an average size of about 8–75 nm, and energy dispersive X-ray spectroscopy (EDS) for their optical, structural, morphological, and compositional investigations. The production of a rutile phase of TiO2 with a tetragonal crystal structure was clearly indicated by XRD patterns. The existence of certain sharp Bragg’s peaks were identified in XRD patterns, which could be related to the capping agent stabilizing the nanoparticles according to Hunagund et al. Intense Bragg’s reflection indicates high X-ray scattering centers in the crystalline phase, which could be attributable to capping agents [54]. Sundrarajan et al. (2017) investigated the synthesis of TiO2 NPs with the help of M. citrifolia leaves extract via the hydrothermal method. The TiO2 NPs had higher antibacterial activity against Gram-positive bacteria, suggesting their antimicrobial efficacy against pathogenic diseases, as per scientists. XRD, FTIR, UV–Vis diffuse reflectance (UV–Vis DRS), UV–Vis spectroscopy, Raman spectroscopy, and SEM with EDX techniques were used to evaluate TiO2 NPs. The peaks at 27.3° correspond to the (110) lattice plane of the tetragonal rutile TiO2 phase, and the average crystalline size of the NPs is 10 nm, according to the XRD study. The size of the NPs, between 15–19 nm, is readily visible in SEM imaging with EDAX spectra, which confirmed the formation of pure TiO2 nanopowder. Due to the quantum-confinement effect, green produced TiO2 nanoparticles have lower band gap energy than bulk pure TiO2 nanoparticles, which could have biological significance [55]. In 2013, Solanum trilobatum extract was used to make TiO2 NPs inhibit Pediculus humanus capitis, Hyalomma anatolicum, and Anopheles subpictus. XRD, FTIR, SEM, EDAX, and AFM were used to examine the green-produced TiO2 NPs [55]. Sankar et al. in 2014 prepared the TiO2 NPs by using aqueous leaf extract of Azadirachta indica under pH and temperature-dependent condition and the characterization were confirmed by UV–Vis spectroscopy and Fourier transform infrared spectrum. The interconnected spherical in shape TiO2 NPs with a mean particle size of 124 nm were revealed by SEM and dynamic light scattering (DLS) investigations and zeta potential of −24 mV [56]. In 2011, Velayutham et al. reported for the first time on the employment of aqueous extract of Catharanthus roseus to synthesize TiO2 NPs against Hippobosca maculata and Bovicola ovis. SEM analysis of the synthesized TiO2 NPs showed clustered and irregular shapes mostly aggregated and having the size of 25–110 nm [57]. From the kitchen waste collected, soaked Bengal gram beans (Cicer arietinum L.) were used for the synthesis of TiO2 NPs in this TiCl4 used as precursor. This is studied by Kashale et al. in 2016. Bio–TiO2 was systematically investigated by XRD, Raman spectroscopy, transmission electron microscopy (TEM), TGA, and BET surface area measurement system [48]. In 2013 Gautam Kumar Naik et al. informed the green synthesis of TiO2 NPs with the help of Cinnamomum Tamala leaves extract, which acts as the reductant. The structural and morphological properties of the nanocomposites were studied by X-ray diffraction, UV–visible diffuse reflectance, FT–IR, and transmission electron microscope [58]. The TiO2 NPs were prepared by Kandregula et al. using the fruit waste of Orange Peel extract as one of the precursors as it acts as a reducing agent and contains citric acid as the main source in its peel. The results were also shown by XRD, Particle Size Analyzer (PSA), Fourier Transform Infrared Spectrometer (FT–IR), and Thermo Gravimetric and Differential Thermal Analyzer (TG/DTA) [59]. With the use of Vigna radiata extract, Chatterjee et al. produced TiO2 NPs in 2016. Vigna radiata is a suitable source of reductant for the biosynthesis of these NPs. The findings revealed that oval-shaped TiO2 NPs could be biologically synthesized and that the particles were effective against both Gram-positive and Gram-negative bacteria. 1631.78 cm−1 and 1641.42 cm−1 in the FTIR spectrum suggested O–Ti–O bonding, while a peak at 3000 cm−1 occurred due to –OH stretching [60]. The TiO2 NPs manufactured from various plant species are shown in Table 1 below.

2.4.1. Preparation of Plant Extract

The fresh leaves are thoroughly washed before being thinly sliced, then put in distilled water and kept boiling, after which the plant extract is filtered and ready to use, or the extract can be stored at low temperature for future use [24]. The thermal breakdown of phytochemicals occurs when leaves are heated. As phytochemicals (phenolic acids, alkaloids, proteins, including enzymes, and carbohydrates) are present in the plant extract, they are utilized in the reduction and stabilization stages [61].

2.4.2. Titanium Dioxide (TiO2) NPs

TTIP (titanium tetra isopropoxide), TiCl4, TiO(OH)2 (metatitanic acid or titanyl hydroxide), and TiOSO4 (titanium oxysulphate) are some of the precursors that may be utilized to make TiO2 NPs (titanium oxysulphate) [62]. Depending on the application, the bulk TiO2 particles are dissolved in ethanol or distilled water. The obtained extract is then added into the mixture, drop by drop [63]. After that, the solution was stirred continuously at an appropriate temperature. The emergence of NPs causes a shift in the color of the solution [64].
Finally, the obtained NPs are filtered, distilled water washed, dried, and calcined. The synthesized NPs are stored in a furnace for calcination at temperatures ranging from 400–800 °C to remove excess organic groups [65]. Phytoconstituents in plants are supposed to fulfil at least one of the given functions, according to the classic green chemistry idea: metal salt reduction, hydrolysis of the Ti4+ precursor, solubilization, and polymerization of several intermediates [66].
Table
Table 1. TiO2 NPs prepared by utilizing a variety of plants.
Table 1. TiO2 NPs prepared by utilizing a variety of plants.
S/NPlant ExtractShapeSize (nm)Ref.
1.Ageratina altissimaSpherical20–25[35]
2.Azadirachta indica leaves aqueous
extract		124[56]
3.Curcuma longa50–110[67]
4.Aqueous flower extract of
Calotropis gigantea		160–220[19]
5.Calotropis gigantea10
6.Nyctanthes leaves Extract100–150[68]
7.Leaf aqueous extract
of Psidium guajava		Spherical shape and clusters32[52]
8.Flower aqueous extract of Hibiscus
rosasenansis		Monodispersed and spherical7[69]
9.Aqueous leaf extract of Solanum
trilobatum		spherical and oval70[70]
10.Aloe vera gel extractAlmost spherical80–90[71]
11.0.3% aqueous extract of the latex
of Jatropha curcas L.		spherical and
uneven		25–100[53]
12.Annona squamosa peel extractPolydispersed and spherical23[50]
13.Eclipta prostrataPolydispersed and spherical clusters36–68[72]
14.Leaf extract of
Catharanthus roseus		Clustered5–110[57]
15.Aloe veraIrregular60[73]
16.Aloe vera leaves extractIrregular structure32[49]
17.Peelextractof Citrus reticulata-24[59]

2.5. Microorganism–Based Synthesized of Titanium Dioxide NPs

In recent years, the biosynthesis of NPs using microorganisms has gained popularity as a more ecologically friendly alternative to chemical synthesis methods. These are inexpensive reagents with low toxicity and mild temperature and pressure requirements [74]. For various metal and metal oxide NPs, using microorganisms to generate NPs is a novel method [75]. The optical, chemical, photoelectrochemical, and electrical characteristics of NPs synthesized with microorganisms piqued researchers’ curiosity [76]. The formation of nanoscale materials by microbial cells is a promising method for the synthesis of metal nanoparticles. In environments with high metal concentrations, microbial synthesis can arise and develop. A variety of microorganisms are known to reduce metal ions into metal [77,78,79]. Figure 4 shows schematic diagram of the synthesis process of TiO2 NPs using microorganisms. In recent years, numerous forms and sizes of TiO2 NPs have been described. Bacterial extracts were utilized in the creation of green TiO2 NP production (green review). Bacterial metabolites, like plant extracts, play a key role in the bioreduction and stability of TiO2. Aeromonas hydrophila extract was used to manufacture 28–54 nm NPs that demonstrated effective inhibitory action against Staphylococcus aureus (33 mm inhibition zone) and Staphylococcus pyogenes (31 mm inhibition zone) [80]. The use of fungi to synthesize metallic NPs has gotten widespread interest, and they claim to have certain advantages over other bacterial production processes [81]. On the one hand, TiO2 NPs were manufactured utilizing the Lactobacillus bacterium during the combined action of oxidoreductase enzymes and glucose at moderate pH, while on the other hand, their possible pathogenicity and arduous bacterial manufacturing have minimal possibilities of being commercialized [82]. Mukherjee et al. revealed that the NPs developed had significant benefits, including scalability, facile extraction, high surface area, and economic feasibility. Through enzymatic reactions or metabolites, fungi can transform bulk salt into an atomic or ionic form [83]. The ability of extracts of Aspergillus flavus to reduce Ti ions precursors to TiO2 NPs was demonstrated in this study. These NPs demonstrated strong antibacterial action against E. coli [79]. Figure 5 shows a schematic diagram of the biological process for producing TiO2 NPs, as well as their characterization and applications. Saccharomyces cerevisa extract was also utilized to make TiO2 NPs, and SEM analysis revealed that the size of biosynthetic NPs was 12.6 nm. The existence of quinines and lipid reductases in the organisms was confirmed using FTIR analysis [82]. The surface properties and ionic strength of the culture medium too are important in the synthesis of TiO2 NPs. TiO2 NPs produced by fungi, like bacteria, have safety limits. Nonpathogenic strains, on the other hand, will eliminate the threat and may be commercially exploited [84]. Table 2 shows the synthesis of TiO2 NPs by various bacterial species.

3. Applications of Biogenic TiO2 NPs

The Green technique of NP generation has several applications in mechanical, electrical, and physical sciences, medicine, and engineering technology [94]. As compared to the biogenic TiO2 NPs, the NPs prepared by the microbial species showed a less significant number of practical applications. Green synthesis of NPs, on the other hand, shows a lot of potential when compared to physical and chemical techniques of production. The photocatalytic nanomaterials are commonly utilized to clean water and remove pollutants from the atmosphere [56,95,96,97]. Greenly produced TiO2 NPs offer a wide range of applications in electronics, energy generation devices, batteries, and sensors manufacturing [48,74]. The biosynthesized TiO2 NPs have also been used in biosciences, with photodynamic cancer therapy, antileishmanial agents, and antibacterial medicines among the applications [79,98,99]. The photocatalytic activity and antimicrobial efficacy of TiO2, as well as the most often used biomedical applications that apply mechanistic approaches, are discussed in the sections below.

3.1. Photocatalytic Activity of TiO2 NPs

The valence band has a complete energy level and is populated with electrons, whereas the conduction band has an unfilled energy level and is isolated from the valence band. An empty hole in the conduction band receives an electron from the valence band. The electrons in the valence band are transported to the conduction band to give TiO2 NPs their photocatalytic activity. As TiO2 is a semiconductor, photons of sufficient energy will cause it to produce electron-hole pairs [100]. The electrons in the valence band moved to the conduction band and filled the holes when UV light was absorbed on the TiO2 NPs. When conduction band-activated electrons and valence band holes react with water in the environment and oxygen; reactive oxygen species (ROS), hydroxyl radicals, and superoxide ions are formed [101,102]. In addition to hydroxyl and superoxide radicals, photocatalytic oxidation of nanoparticles, hydrogen peroxide, and singlet oxygen production occur. All of these radicals are known to be extremely reactive and can quickly destroy organic compounds when they come into contact with them [103,104]. Nowadays, household and industrial wastes contain a variety of hazardous and harmful substances, such as poisonous dyes and nitroarene compounds, which pollute the environment and cause water contamination. Hazardous dyes and other obnoxious substances have poor solubility and high stability, therefore justifying their tenacity and threat to aquatic life [105]. Freshly synthesized metallic NPs with a high catalytic capability and a specific structure were created. These metallic NPs also have a huge surface area, making them good heterogeneous catalysts [106]. The nanostructured catalysts also have the advantage of being easily recovered and recycled with the reaction mixture. The NPs’ toxicity, as well as their aggregation, are crucial aspects [107,108]. As a result of its high stability, low toxicity, optical properties, and photocatalytic potential, TiO2 NPs have largely been used in catalysis. Several studies claimed that green–mediated TiO2 NPs may be utilized to photo–catalytically reduce different dyes and compounds [56,97,109,110,111,112,113]. The sample was generated with 0.001 mol of TTIP precursor and yielded excellent results with lower particle sizes of 64.18 nm, indicating superior performance in photocatalytic activities [113]. The incubation composite displayed improved photocatalytic activity, while also degrading the rhodamine B dye and displaying maximum photocatalytic activity [112]. When green mediated NPs were compared to chemically synthesized TiO2 NPs for photocatalytic potential, green mediated NPs outperformed chemically prepared TiO2 NPs. The ability to reduce depends on phytochemicals found in plant species, the type of dye used, and the temperature [98]. The catalytic potential of doped TiO2 NPs with other metallic NPs was improved [114]. Table 3 shows the photocatalytic performance of TiO2 NPs that synthesized using different plant extracts [24,56,113,115,116,117,118,119].

3.2. Antimicrobial Potency of TiO2 NPs

Antimicrobial applications also make use of TiO2. In their investigation, Matsunaga et al. in 1988 found that TiO2 powder catalysts killed 99% of E. coli bacteria within 0.27 h when exposed to UV radiation (1800 µE m−2 s−1) [120]. This system is called a photo-sterilization system, which can be conducted in Figure 6. There are so many investigations that have been conducted to see the effect of TiO2 NPs catalysts on different bacteria. Maness et al. found that ROS formed on TiO2 surfaces, causing a lipid peroxidation reaction and the death of E. coli K–12 cells [121]. Numerous investigations have been conducted to examine how TiO2 NPs used for bactericidal purposes affect bacteria cells such as E. coli, Pseudomonas aeruginosa, S. aureus, Enterococcus hirae, and Bacteroides fragilis have been killed by the effects of TiO2 nanoparticles when exposed to UV light [122].
In the literature, biosynthesized TiO2 NPs were mediated and employed against several bacteria types [123]. Biosynthesized TiO2 NPs are ecologically friendly, have a high oxidizing potential, and are used in biomedicine. Biosynthesize TiO2 NPs were employed against a variety of bacteria, including strains, fungus, algae, viruses, and microbial toxins [124]. Table 4 reported the antimicrobial effect of TiO2 NPs against different bacteria. Figure 7 shows simple experimental scheme for photochemical antimicrobial mechanism of TiO2 catalyst. The impact of TiO2 NPs on microbes is depicted in Figure 8 as a proposed pathway. When TiO2 NPs come into contact with microbial cells, they form reactive oxygen species (ROS) [80]. ROS acted to reduce adhesion by killing bacteria by disrupting cell wall integrity, stopping respiratory cytosolic enzymes from changing macromolecule structures, and having strong effects on cellular integrity and gene expression. Phosphate uptake and cellular communication are also inhibited [80,125]. In comparison to both green produced and chemically generated TiO2 NPs, bio-synthesized NPs showed greater antibacterial activity. The capping agents obtained from plant extracts are credited with their excellent antibacterial properties [69]. The antibacterial action of NPs is influenced by their structure, membrane biology, and bacteria species. Green TiO2 NPs are employed to slow both Gram-positive and Gram-negative bacteria, albeit Gram-positive bacteria are less reactive than Gram-negative bacteria due to their structural complexity [19]. If bio–mediated TiO2 NPs are irradiated with UV and fluorescent light, their antibacterial activity can be improved [50,80]. When green-produced TiO2 NPs were introduced to Leishmanial cells, they demonstrated enhanced antileishmanial activity as well as decreased cell viability, slow growth, and DNA fragmentation [125]. TiO2 NPs surpassed typical antibiotic discs in terms of antibacterial activity [52].

4. Future Challenges

Synthetic methods involving fungus, bacteria, and other organisms are complex due to strain separation and difficulties in growth. These processes are also difficult owing to the need to maintain the culture media, as well as the physical and chemical conditions. Plants are selected primarily since they are simple to extract and plentiful. This approach might be used to regulate the size, shape, and crystalline structure by adjusting the experimental parameters. Despite this, only a few plants are exploited in the phyto-synthesis of TiO2 NPs, and additional study is urgently required in this field. These phyto-synthesized nanoparticles may be used safely not just in biomedical activities, but also in all other potential applications as they are similarly compatible with chemically produced nanoparticles. As previously stated, the crucial aspects of NP are determined by their size and shape. As a result, future difficulties will include figuring out how to leverage similar biological techniques to make various forms including triangular, cuboidal, truncated, ellipsoidal, pyramidal, decahedral, and oval. Scaling up NP production from the lab to the commercial-scale is a tough process with many challenges and unknowns. There are two more obstacles to overcome. All across the production process, cost, dependability, waste, energy consumption, recycling possibilities, material safety, and hazard level should all be addressed. Furthermore, the properties of nanomaterials may change as they scale up. The amount of control may be diminished when dealing with large volumes.

5. Summary

The recent research effort in the topic of biogenic synthesis of TiO2 NPs using plants and microbes has been discussed in this review. It also delves further into the mechanism of TiO2 NPs’ phyto-synthesis. Despite metallic nanoparticles being formed through different physicochemical processes, their cytotoxicity, high cost, and time consuming production have prompted scientists to propose new nanostructures design methods. The formation of titanium dioxide nanoparticles from various biological sources (plants, microorganisms, and related bioproducts) has been discussed. Furthermore, the mechanism of their uptake, translocation, and accumulation in plants are explored. The potential impact of TiO2 has also reported. The green synthesis is being promoted due to a number of significant advantages associated with this technique. This approach might be used to regulate the size, shape, and crystalline structure by adjusting the experimental parameters. Despite this, only a few plants are exploited in the phyto-synthesis of TiO2 NPs, and additional study is urgently required in this field. These phyto-synthesized nanoparticles may be used safely not just in biomedical activities, but also in all other potential applications as they are similarly compatible with chemically produced nanoparticles. Apart from biomedical and environmental remediation applications, further scientific research should be devoted to finding practical uses of phyto-synthesized NPs in other fields. To summarize, green technology via biosynthesis, as discussed in the article, yields outstanding insights that may encourage foster researchers and beginners to proceed and expand their investigation of nature’s potential, as well as the development of effective and sustainable methodologies for nanoparticle synthesis with desirable characteristics, which can be utilized in a variety of disciplines.

Author Contributions

Conceptualization, J.S. and M.R.; formal analysis, J.S. and M.R.; investigation, J.S.; data curation, J.S.; writing—original draft preparation, V.V. and M.G.M.K.; writing—review and editing, J.S., M.R., M.A.-D., M.G.M.K. and M.S.; visualization, J.S., M.G.M.K. and M.S.; supervision, J.S. and M.R.; project administration, M.A.-D.; funding acquisition, M.A.-D. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.

Acknowledgments

The authors gratefully acknowledge Chandigarh University, Mohali, and Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab (India) for necessary resources. JS would like to dedicate this work to the late Mohit Rawat (Former Head Department of Nanotechnology, Sri Guru Granth Sahib World University), under whose supervision this work was carried out. Moreover, this work was supported by the King Khalid University through a grant KKU/RCAMS/G0001-21 under the Research Center for Advanced Materials (RCAMS) at King Khalid University, Saudi Arabia.

Conflicts of Interest

The authors declare no conflict of interest.

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Polymers 14 01444 g001 550
Figure 1. Histogram shows the proportion of papers published on green techniques for TiO2 NPs.
Figure 1. Histogram shows the proportion of papers published on green techniques for TiO2 NPs.
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Polymers 14 01444 g002 550
Figure 2. Nanoparticle synthesis methods.
Figure 2. Nanoparticle synthesis methods.
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Figure 3. Schematic diagram of the preparation process of nanoparticles via plant extract.
Figure 3. Schematic diagram of the preparation process of nanoparticles via plant extract.
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Figure 4. Schematic diagram of the synthesis process of TiO2 NPs using microorganisms.
Figure 4. Schematic diagram of the synthesis process of TiO2 NPs using microorganisms.
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Figure 5. Green synthesis of TiO2 NPs.
Figure 5. Green synthesis of TiO2 NPs.
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Figure 6. TiO2 NPs driven photocatalytic process in the presence of light.
Figure 6. TiO2 NPs driven photocatalytic process in the presence of light.
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Figure 7. Simple experimental scheme for photochemical antimicrobial mechanism of TiO2 catalyst.
Figure 7. Simple experimental scheme for photochemical antimicrobial mechanism of TiO2 catalyst.
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Figure 8. The impact of TiO2 NPs on microbes is depicted as a proposed pathway.
Figure 8. The impact of TiO2 NPs on microbes is depicted as a proposed pathway.
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Table
Table 2. TiO2 NPs produced by several bacterial communities.
Table 2. TiO2 NPs produced by several bacterial communities.
S/NBacterial SpeciesShapeSize (nm)Ref.
1.Aeromonas hydrophilaSpherical40–50[80]
2.Bacillus amyloliquefaciens22.1–97.2[78]
3.Bacillus subtilis30–40[85]
4.Bacillus subtilisSpherical66–77[86]
5.Bacillus subtilis10–30[75]
6.Lactobacillus8–35[82]
7.Lactobacillus40–60[87]
8.Planomicrobium100[88]
9.Aspergillus niger73.58[89]
10.Fusarium oxysporum10[90]
11Aspergillus flavus62–74[79]
12.Bacillus mycoidesPolydisperse40–60[74]
13.Fusarium oxysporumQuasi–spherical9.8[91]
14.Aspergillus tubingensis-<100[92]
15.Aspergillus niger, Rhizoctonia bataticola,
Aspergillus fumigatus, and Aspergillus oryzae.		--[93]
Table
Table 3. Photocatalytic effect of Titanium dioxide nanoparticles using different plant extracts.
Table 3. Photocatalytic effect of Titanium dioxide nanoparticles using different plant extracts.
S/NDyeConcentration
of Dye		Catalyst DosageExposure TimePercentage RemovalRef.
1.methylene blue (MB) dye6, 10, 20, 40 ppm0.1–0.4g6 mg. L−1 of MB in 45 min13.3%[113]
2.methylene blue, alizarin red, crystal violet, and methyl orange10 mg/L50 mL6 h86.79%, 76.32%, 77.59% and 69.06%[115]
3.methyl orange-1 g/dm3150 min94%[24]
4.RO–4 dye-15 mg, 20 mg, 25 mg and 30 mg180 min at 3.5 pH91.19%[116]
5.methyl red10 ppm and 20 ppm1 g/L60 min89% and 83%[117]
6.methyl red50 mL10 mg120 min-[56]
7.Methyl Blue200 mL10 mg75 min-[118]
8.indigo blue dye1 ppm at pH 6.0-150 min75%[119]
Table
Table 4. Antimicrobial effect of Titanium dioxide NPs using different bacteria.
Table 4. Antimicrobial effect of Titanium dioxide NPs using different bacteria.
S/NCatalystDosageSpecies NameZone of InhibitionRef.
1.TiO225 µg mL−1, 20 µg mL−1, 30 µg mL−1, 10 µg mL−1, 10 µg mL−1, 15 µgmL−1A. hydrophila, E. coli, P. aeruginosa, S. pyogenes, S. aureus, E. faecalis23 mm, 26 mm, 25 mm,
31 mm, 33 mm, 16 mm		[80]
2.TiO220 μg/mL, 40 μg/mLE. coli [74]
3.TiO220 μg/mLS. aureus
and E. coli		25 mm, 23 mm[52]
4.TF–TiO220 μL of 10 mg/mLS. aureus, S. faecalis, E. coli,
E. faecalis, Y. enterocolitica		11.2 mm, 11.6 mm,
10.8 mm, 11.4 mm,
10.6 mm		[94]
5.A. flavus synthesized TiO240 µg mL−1, 40 µg mL−1, 80 µg mL−1, 70 µg mL−1, 75 µg mL−1S. aureus, E. coli, P. aeruginosa, K. pneumonia, B. subtilis25 mm, 35 mm, 27 mm, 18 mm, 22 mm[79]
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Verma, V.; Al-Dossari, M.; Singh, J.; Rawat, M.; Kordy, M.G.M.; Shaban, M. A Review on Green Synthesis of TiO2 NPs: Photocatalysis and Antimicrobial Applications. Polymers 2022, 14, 1444. https://doi.org/10.3390/polym14071444

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Verma V, Al-Dossari M, Singh J, Rawat M, Kordy MGM, Shaban M. A Review on Green Synthesis of TiO2 NPs: Photocatalysis and Antimicrobial Applications. Polymers. 2022; 14(7):1444. https://doi.org/10.3390/polym14071444

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Verma, Vishal, Mawaheb Al-Dossari, Jagpreet Singh, Mohit Rawat, Mohamed G. M. Kordy, and Mohamed Shaban. 2022. "A Review on Green Synthesis of TiO2 NPs: Photocatalysis and Antimicrobial Applications" Polymers 14, no. 7: 1444. https://doi.org/10.3390/polym14071444

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