Coordinated Dialogue between UHRF1 and DNMT1 to Ensure Faithful Inheritance of Methylated DNA Patterns
Abstract
:1. Introduction
1.1. DNA Methylation Patterns: Layers of Epigenomes
1.2. The Role of UHRF1/DNMT1 Tandem
1.3. UHRF1 and DNMT1, Interdependent Multi-Domain Proteins
2. The UHRF1/DNMT1 Dialogue on Chromatin
2.1. The Ubiquitination of Histone H3 by UHRF1 as a Chromatin Anchorage for DNMT1: Model A
2.2. Domain–Domain Interactions between DNMT1 and UHRF1: Model B
2.3. A Conciliated Model of How the UHRF1/DNMT1 Tandem Works
3. Concluding Remarks
Author Contributions
Funding
Conflicts of Interest
References
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Bronner, C.; Alhosin, M.; Hamiche, A.; Mousli, M. Coordinated Dialogue between UHRF1 and DNMT1 to Ensure Faithful Inheritance of Methylated DNA Patterns. Genes 2019, 10, 65. https://doi.org/10.3390/genes10010065
Bronner C, Alhosin M, Hamiche A, Mousli M. Coordinated Dialogue between UHRF1 and DNMT1 to Ensure Faithful Inheritance of Methylated DNA Patterns. Genes. 2019; 10(1):65. https://doi.org/10.3390/genes10010065
Chicago/Turabian StyleBronner, Christian, Mahmoud Alhosin, Ali Hamiche, and Marc Mousli. 2019. "Coordinated Dialogue between UHRF1 and DNMT1 to Ensure Faithful Inheritance of Methylated DNA Patterns" Genes 10, no. 1: 65. https://doi.org/10.3390/genes10010065