Genes 2014, 5(1), 65-83; doi:10.3390/genes5010065
The Genomic Signature of Breast Cancer Prevention
The Irma H. Russo MD Breast Cancer Research Laboratory, Fox Chase Cancer Center, Temple University Health System, 333 Cottman Avenue, Philadelphia, PA 19111, USA
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Received: 18 December 2013 / Revised: 31 January 2014 / Accepted: 8 February 2014 / Published: 26 February 2014
(This article belongs to the Special Issue Grand Celebration: 10th Anniversary of the Human Genome Project)
Abstract
The breast of parous postmenopausal women exhibits a specific signature that has been induced by a full term pregnancy. This signature is centered in chromatin remodeling and the epigenetic changes induced by methylation of specific genes which are important regulatory pathways induced by pregnancy. Through the analysis of the genes found to be differentially methylated between women of varying parity, multiple positions at which beta-catenin production and use is inhibited were recognized. The biological importance of the pathways identified in this specific population cannot be sufficiently emphasized because they could represent a safeguard mechanism mediating the protection of the breast conferred by full term pregnancy. View Full-TextKeywords:
normal breast; breast cancer; genomic signature; prevention; pregnancy; splicing mechanisms; methylation; chromatin remodeling; Lnc-RNA; beta-catenin
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Russo, J.; Santucci-Pereira, J.; Russo, I.H. The Genomic Signature of Breast Cancer Prevention. Genes 2014, 5, 65-83.