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Genes 2017, 8(3), 88; doi:10.3390/genes8030088

MYC in Regulating Immunity: Metabolism and Beyond

Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, The Research Institute at Nationwide Children’s Hospital, Ohio State University, Columbus, OH 43205, USA
Author to whom correspondence should be addressed.
Academic Editor: Daitoku Sakamuro
Received: 1 January 2017 / Revised: 9 February 2017 / Accepted: 16 February 2017 / Published: 25 February 2017
(This article belongs to the Special Issue MYC Networks)
View Full-Text   |   Download PDF [1058 KB, uploaded 25 February 2017]   |  


Myelocytomatosis oncogene (MYC) family members, including cellular MYC (c-Myc), neuroblastoma derived MYC (MYCN), and lung carcinoma derived MYC (MYCL), have all been implicated as key oncogenic drivers in a broad range of human cancers. Beyond cancer, MYC plays an important role in other physiological and pathological processes, namely immunity and immunological diseases. MYC largely functions as a transcription factor that promotes the expression of numerous target genes to coordinate death, proliferation, and metabolism at the cellular, tissue, and organismal levels. It has been shown that the expression of MYC family members is tightly regulated in immune cells during development or upon immune stimulations. Emerging evidence suggests that MYC family members play essential roles in regulating the development, differentiation and activation of immune cells. Through driving the expression of a broad range of metabolic genes in immune cells, MYC family members coordinate metabolic programs to support immune functions. Here, we discuss our understanding of MYC biology in immune system and how modulation of MYC impacts immune metabolism and responses. View Full-Text
Keywords: MYC; immunity; metabolism MYC; immunity; metabolism

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gnanaprakasam, J.R.; Wang, R. MYC in Regulating Immunity: Metabolism and Beyond. Genes 2017, 8, 88.

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