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Article
Peer-Review Record

Overexpressed Proteins in HCC Cell-Derived Exosomes, CCT8, and Cofilin-1 Are Potential Biomarkers for Patients with HCC

Diagnostics 2021, 11(7), 1221; https://doi.org/10.3390/diagnostics11071221
by Hyo Jung Cho 1, Geum Ok Baek 1, Moon Gyeong Yoon 1, Hye Ri Ahn 1,2, Ju A Son 1,2, Soon Sun Kim 1, Jae Youn Cheong 1,* and Jung Woo Eun 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Diagnostics 2021, 11(7), 1221; https://doi.org/10.3390/diagnostics11071221
Submission received: 17 June 2021 / Accepted: 2 July 2021 / Published: 6 July 2021
(This article belongs to the Collection Biomarkers in Medicine)

Round 1

Reviewer 1 Report

The topic of this research, to investigate the clinical significance of several protein markers of hepatocellular carcinoma (HCC)-derived exosomes (HEX) is very challenging. Although a few previous studies have associated CCT8 2 and Cofilin-1 with HCC, this study underlines their potential serum diagnostic biomarkers for patients with HCC.

Consequently, this paper could bring new data in the HCC field if published in the Diagnostic journal.

Reviewer 2 Report

The manuscript on overexpressed Proteins in HCC cell-derived Exosomes, CCT8 2 and Cofilin-1 being potential biomarkers for patients with HCC is comprehensive and well written with elegant experimental design. The interpretation of results are sound and aligns with the conclusion. The authors acknowledge the limitations in identifying mechanisms of action, which is beyond the scope of this manuscript. I recommend this manuscript for publication. 

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