Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Setting
2.3. Participants
2.4. Data Sources
2.5. Variables
2.6. Statistical Analysis
3. Results
3.1. Participants and Lesion Data
3.2. ×20 Dermoscopy
3.3. ×400 Dermoscopy
3.4. Multivariate Analysis
4. Discussion
Supplementary Materials
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Benign Lesions n = 117 | Malignant Lesions n = 73 | p-Value | |
---|---|---|---|
Age (years; SD) | 48.79 (19.19%) | 64.98 (16.70%) | <0.001 |
Male | 68 (61.3%) | 31 (56.4%) | 0.846 |
Female | 49 (38.7%) | 42 (43.6%) |
Benign Lesions | Malignant Lesions | p-Value | |
---|---|---|---|
7-point checklist | |||
Atypical pigment network | 57 (48.7%) | 59 (80.8%) | <0.001 |
Blue-whitish veil | 18 (15.4%) | 49 (67.1%) | <0.001 |
Atypical vascular pattern | 1 (0.9%) | 12 (16.4%) | <0.001 |
Irregular streaks | 11 (9.4%) | 22 (30.1%) | 0.001 |
Regression structures | 33 (28.2%) | 49 (67.1%) | <0.001 |
Irregular pigmentations | 40 (34.2%) | 23 (31.5%) | 0.823 |
Irregular dots/globules | 36 (30.8%) | 18 (24.7%) | 0.457 |
General pattern | |||
Homogeneous | 32 (27.4%) | 43 (58.9%) | <0.001 |
Globular | 41 (35.0%) | 7 (9.6%) | <0.001 |
Network | 67 (57.3%) | 41 (56.2%) | 1.000 |
Benign Lesions | Malignant Lesions | p-Value | |
---|---|---|---|
Cell presence | 113 (96.6%) | 72 (98.6%) | 0.695 |
Keratinocytes | 109 (93.2%) | 64 (87.7%) | 0.304 |
Roundish melanocytes | 35 (29.9%) | 36 (49.3%) | 0.011 |
Dendritic melanocytes | 19 (16.2%) | 22 (30.1%) | 0.037 |
Melanophages | 19 (16.2%) | 17 (23.3%) | 0.310 |
Cell color | |||
Black | 13 (11.1%) | 7 (9.6%) | 0.929 |
Brown | 107 (91.5%) | 66 (90.4%) | 1.000 |
Violet/blue | 45 (38.5%) | 29 (39.7%) | 0.983 |
Cell irregularity in shape and size | 21 (17.9%) | 38 (52.1%) | <0.001 |
Cell distribution: irregular arrangement | 19 (16.2%) | 30 (41.1%) | <0.001 |
Roundish nests | 42 (35.9%) | 22 (30.1%) | 0.510 |
Out-of-focus structureless areas | |||
Bluish | 36 (30.8%) | 24 (32.9%) | 0.886 |
Grey/brown | 23 (19.7%) | 11 (15.1%) | 0.543 |
Vessels | 26 (22.2%) | 23 (31.5%) | 0.210 |
Network | |||
with edged papillae | 30 (25.6%) | 3 (4.1%) | <0.001 |
without edged papillae | 18 (15.4%) | 19 (26.0%) | 0.107 |
Angled nest | 9 (7.7%) | 16 (22.2%) | 0.008 |
OR | p-Value | |
---|---|---|
Age | 1.05 (1.03–1.09) | <0.001 |
Irregular melanocyte distribution | 4.69 (1.58–15.45) | 0.007 |
Network with edged papillae | 0.16 (0.03–0.57) | 0.009 |
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Share and Cite
Cinotti, E.; Cioppa, V.; Tognetti, L.; Perrot, J.L.; Rossi, R.; Gnone, M.; Cartocci, A.; Rubegni, P.; Cortonesi, G. Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions. Diagnostics 2023, 13, 2238. https://doi.org/10.3390/diagnostics13132238
Cinotti E, Cioppa V, Tognetti L, Perrot JL, Rossi R, Gnone M, Cartocci A, Rubegni P, Cortonesi G. Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions. Diagnostics. 2023; 13(13):2238. https://doi.org/10.3390/diagnostics13132238
Chicago/Turabian StyleCinotti, Elisa, Vittoria Cioppa, Linda Tognetti, Jean Luc Perrot, Renato Rossi, Matteo Gnone, Alessandra Cartocci, Pietro Rubegni, and Giulio Cortonesi. 2023. "Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions" Diagnostics 13, no. 13: 2238. https://doi.org/10.3390/diagnostics13132238