Plasma Disappearance Rate of Indocyanine Green for Determination of Liver Function in Three Different Models of Shock
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Surgical Procedures
2.3. Experimental Protocol
2.4. Evaluation of PDRICG
2.5. Calculation of ICG Blood Clearance and Compartment Models
2.6. Statistical Analysis
3. Results
3.1. Hemodynamics and Blood Gas Analysis
3.2. Plasma Disappearance Rate of Indocyanine Green
3.3. Calculation of 1-Compartment Models
3.4. Calculation of 2-Compartment Models
3.5. Calculation of 3-Compartment Models
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Baseline | 90 Min | End of Experiment | |
---|---|---|---|
pH | |||
Sham | 7.37 ± 0.04 | 7.36 ± 0.05 | 7.36 ± 0.08 |
Hemorrhage | 7.37 ± 0.04 | 7.25 ± 0.07 | 7.34 ± 0.06 |
Moderate Endotoxemia | 7.36 ± 0.05 | 7.35 ± 0.08 | 7.25 ± 0.07 |
Severe Endotoxemia | 7.37 ± 0.05 | 7.33 ± 0.09 | 7.19 ± 0.09 |
Hb [g/dl] | |||
Sham | 10.7 ± 1.1 | 11.0 ± 1.2 | 10.4 ± 1.4 |
Hemorrhage | 11.2 ± 1.0 | 6.2 ± 1.5 | 8.8 ± 1.3 |
Moderate Endotoxemia | 10.8 ± 0.8 | 10.0 ± 1.6 | 9.8 ± 1.5 |
Severe Endotoxemia | 10.6 ± 1.2 | 10.1 ± 1.2 | 9.9 ± 1.5 |
BE [mmol/L] | |||
Sham | 0.1 ± 1.9 | −0.8 ± 3.2 | −0.6 ± 4.0 |
Hemorrhage | −0.2 ± 2.2 | −10.2 ± 3.9 | −2.0 ± 3.5 |
Moderate Endotoxemia | 0.3 ± 1.4 | −2.2 ± 1.9 | −9.7 ± 3.8 |
Severe Endotoxemia | 0.4 ± 1.7 | −3.0 ± 2.1 | −14.2 ± 5.5 |
Lactate [mmol/L] | |||
Sham | 1.5 ± 0.5 | 1.5 ± 0.4 | 1.6 ± 0.6 |
Hemorrhage | 1.7 ± 0.7 | 7.9 ± 1.5 | 1.8 ± 0.6 |
Moderate Endotoxemia | 1.6 ± 0.6 | 2.4 ± 1.2 | 8.3 ± 0.7 |
Severe Endotoxemia | 1.7 ± 0.7 | 2.2 ± 1.3 | 9.7 ± 0.6 |
Sham | Hemorrhage | Moderate Endotoxemia | Severe Endotoxemia | |
---|---|---|---|---|
1-compartment model | ||||
ICG Distribution Volume (mL) | 60.3 | 41.6 | 32.6 | 42.8 |
Calculated ICG Clearance (mL/min/m2) | 564.0 | 174.0 | 387.0 | 202.0 |
2-compartment model | ||||
ICG Distribution Volume 1 (mL) | 16.2 | 20.2 | 13.3 | 14.1 |
Calculated ICG Clearance 1 (mL/min/m2) | 246.0 | 84.0 | 305.0 | 181.0 |
ICG Distribution Volume 2 (mL) | 289.9 | 85.6 | 93.3 | 25.5 |
Calculated ICG Clearance 2 (mL/min/m2) | 211.0 | 170.0 | 90.0 | 467.0 |
Micro-rate constant k10 | 0.15 | 0.04 | 0.22 | 0.12 |
Micro-rate constant k12 | 0.13 | 0.08 | 0.06 | 0.33 |
Micro-rate constant k21 | 0.007 | 0.01 | 0.009 | 0.18 |
3-compartment model | ||||
ICG Distribution Volume 1 [mL] | 11.7 | 0.01 | 12.8 | 14.1 |
Calculated ICG Clearance 1 [mL/min/m2] | 137.0 | 134.0 | 300.0 | 181.0 |
ICG Distribution Volume 2 [mL] | 4.37 | 3.85 | 7.89 | 10.00 |
Calculated ICG Clearance 2 [mL/min/m2] | 1132.0 | 94.0 | 421.0 | 182.0 |
ICG Distribution Volume 2 [mL] | 736.9 | 21.4 | 3.4 | 15.5 |
Calculated ICG Clearance 2 [mL/min/m2] | 313.0 | 222.0 | 677.0 | 284.0 |
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Mathes, A.; Plata, C.; Rensing, H.; Kreuer, S.; Fink, T.; Raddatz, A. Plasma Disappearance Rate of Indocyanine Green for Determination of Liver Function in Three Different Models of Shock. Diagnostics 2019, 9, 108. https://doi.org/10.3390/diagnostics9030108
Mathes A, Plata C, Rensing H, Kreuer S, Fink T, Raddatz A. Plasma Disappearance Rate of Indocyanine Green for Determination of Liver Function in Three Different Models of Shock. Diagnostics. 2019; 9(3):108. https://doi.org/10.3390/diagnostics9030108
Chicago/Turabian StyleMathes, Alexander, Christopher Plata, Hauke Rensing, Sascha Kreuer, Tobias Fink, and Alexander Raddatz. 2019. "Plasma Disappearance Rate of Indocyanine Green for Determination of Liver Function in Three Different Models of Shock" Diagnostics 9, no. 3: 108. https://doi.org/10.3390/diagnostics9030108
APA StyleMathes, A., Plata, C., Rensing, H., Kreuer, S., Fink, T., & Raddatz, A. (2019). Plasma Disappearance Rate of Indocyanine Green for Determination of Liver Function in Three Different Models of Shock. Diagnostics, 9(3), 108. https://doi.org/10.3390/diagnostics9030108