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Pathogens 2012, 1(1), 52-64; doi:10.3390/pathogens1010052

Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin’s Lymphoma

School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
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Received: 14 August 2012 / Revised: 28 August 2012 / Accepted: 4 September 2012 / Published: 19 September 2012
(This article belongs to the Special Issue Infection and Cancer)
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Abstract

Although there is increasing evidence that aberrant expression of those enzymes which control protein arginine methylation contribute to carcinogenesis, their de-regulation by oncogenic viruses in primary cells has yet to be reported. We first show that the protein arginine methyltransferases, CARM1, PRMT1 and PRMT5 are strongly expressed in Hodgkin Reed-Sternberg (HRS) cells, and up-regulated in Hodgkin's lymphoma (HL) cell lines. Given that Epstein-Barr virus (EBV) can be detected in approximately 50% of primary HL, we next examined how EBV infection of germinal centre (GC) B cells, the presumptive precursors of HRS cells, modulated the expression of these proteins. EBV infection of GC B cells was followed by the up-regulation of CARM1, PRMT1 and PRMT5, and by the down-regulation of the arginine deiminase, PADI4. Latent membrane protein 1 (LMP1), the major EBV transforming gene was shown to induce PRMT1 in GC B cells and in a stably transfected B cell line. The recent development of compounds which inhibit PRMT-mediated reactions provides a compelling case for continuing to dissect the contribution of virus induced changes in these proteins to lymphomagenesis.
Keywords: protein arginine methyltransferases; Epstein-Barr virus; LMP1; Hodgkin’s lymphoma; PRMT1; epigenetics protein arginine methyltransferases; Epstein-Barr virus; LMP1; Hodgkin’s lymphoma; PRMT1; epigenetics
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Leonard, S.; Gordon, N.; Smith, N.; Rowe, M.; Murray, P.G.; Woodman, C.B. Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin’s Lymphoma. Pathogens 2012, 1, 52-64.

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