Comparative Bioinformatic Analysis of the Proteomes of Rabbit and Human Sex Chromosomes
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Datasets Obtention and Filtering
2.2. Functional Annotation
2.2.1. UniProt Database
2.2.2. eggNOG-Mapper
2.3. Protein Topology Prediction
2.4. Identification of Proteins Associated with the Plasma Membrane
2.5. Statistical Overrepresentation Test of the Rabbit X Chromosome Proteome
2.6. Cross-Species Analysis: Identification of Human Targets in the Rabbit Proteome
2.6.1. Data Extraction
2.6.2. Alignment and Similarity
2.6.3. Manual Curation
2.7. Cross-Reference of the Common Human and Rabbit Targets with Human Spermatozoa Proteins
3. Results
3.1. Proteomes Filtering Process
3.2. Analysis of the Sex Chromosomes Proteome
3.2.1. Characterization of the Rabbit X Chromosome Proteome
Overrepresentation Analysis of the Rabbit X Chromosome Proteome
3.2.2. Characterization of the Human X and Y Chromosomes Proteome
3.3. Cross-Species Analysis: Identification of Human Targets in the Rabbit Proteome
3.4. Cross-Reference of the Common Human and Rabbit Targets with Human Spermatozoa Proteins
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Protein ID | Gene Name | Protein Name | Topology | GO Terms |
---|---|---|---|---|
G1TEF4 | ACE2 | Angiotensin-converting enzyme | SP+TM | CS, PM, ES † |
G1SSU5 | ADGRG2 | Adhesion G protein-coupled receptor G2 | SP+TM | PM † |
Q8MKE9 | AGTR2 | Type-2 angiotensin II receptor | TM | PM † |
G1SMQ1 | AMOT | Angiomotin | GLOB | CS, PM, ESPM † |
G1T923 | ATP6AP2 | Renin receptor | SP+TM | CS, PM, ESPM † |
G1T6U3 | ATP7A | P-type Cu(+) transporter | TM | PM † |
G1TUV0 | BRS3 | Bombesin receptor subtype-3 | TM | PM † |
G1SNI0 | CACNA1F | Calcium voltage-gated channel subunit alpha1 F | TM | PM † |
G1SV48 | CD24 * | CD24 molecule | SP | CS, PM, ESPM, ACPM, ACESPM † |
G1SKP7 | CD40LG | CD40 ligand | TM | CS, PM, ESPM, ES † |
Q9TTU3 | CLCN5 | H(+)/Cl(−) exchange transporter 5 | TM | PM † |
G1TSU9 | CLDN2 | Claudin 2 | TM | PM |
G1T4N6 | CLTRN | Collectrin, amino acid transport regulator | SP+TM | PM † |
A0A5F9CEX7 | CXCR3 | C-X-C chemokine receptor type 3 | TM | CS, PM, ESPM † |
A0A5F9CNI6 | CYBB | Cytochrome b-245 beta chain | TM | PM, ICPM † |
G1TB31 | CYSLTR1 | Cysteinyl leukotriene receptor 1 | TM | PM, ICPM † |
G1T9S6 | EDA | Ectodysplasin A | TM | PM, ES, ICPM † |
A0A5F9D0L9 | EDA2R | Ectodysplasin A2 receptor | SP+TM | PM |
A0A5F9CVB5 | EFNB1 | Ephrin B1 | SP+TM | PM† |
G1TPG8 | ENOX2 | Ecto-NOX disulfide-thiol exchanger 2 | GLOB | CS, PM, ESPM † |
A0A5F9CPD1 | GDPD2 | Glycerophosphodiester phosphodiesterase domain containing 2 | TM | PM † |
G1TMB8 | GJB1 | Gap junction protein | TM | PM † |
G1T1J4 | GLRA2 | Glycine receptor alpha 2 | SP+TM | PM, ICPM † |
G1T836 | GLRA4 * | Glycine receptor alpha 4 | SP+TM | PM, ICPM † |
A0A5F9DIT5 | GPC4 | Glypican 4 | TM | CS, PM, ESPM † |
G1SN36 | GPR174 | G protein-coupled receptor 174 | TM | PM |
G1SD16 | GRIA3 | Glutamate receptor | SP+TM | PM, ICPM † |
G1T4A8 | GRPR | Gastrin-releasing peptide receptor | TM | PM, ICPM † |
G1SXP0 | GUCY2F | Guanylate cyclase | SP+TM | PM † |
A0A5F9C5Z9 | HEPH | Hephaestin | SP+TM | PM † |
A0A5F9DJ94 | HNRNPM * | RRM domain-containing protein | GLOB | CS† |
G1TAG7 | HTR2C | 5-hydroxytryptamine receptor 2C | SP+TM | CS, PM, ESPM, ICPM † |
G1TBS6 | IL1RAPL1 | Interleukin-1 receptor accessory protein-like 1 | SP+TM | CS, PM † |
G1TPE7 | IL2RG * | Cytokine receptor common subunit gamma | TM | CS, PM, ESPM † |
G1SVL1 | ITM2A | Integral membrane protein 2 | TM | PM |
G1TSW5 | KCNE5 | Potassium voltage-gated channel subfamily E regulatory subunit 5 | TM | PM, ICPM † |
U3KP42 | MMGT1 * | Membrane magnesium transporter | TM | PM † |
G1SCP8 | MSN * | Moesin | GLOB | CS, PM † |
G1TU56 | NDP | Norrin cystine knot growth factor NDP | SP | CS, ES † |
G1TYL9 | NLGN3 | Neuroligin 3 | SP+TM | CS, PM, ICPM † |
G1SPD7 | NOX1 | NADPH oxidase 1 | TM | PM, ICPM † |
G1T124 | OR13H1 | Olfactory receptor family 13 subfamily H member 1 | TM | PM |
G1TCY0 | P2RY4 | P2Y purinoceptor 4 | TM | PM † |
A0A5F9DQS9 | PCDH11X * | Cadherin domain-containing protein | SP+TM | PM |
G1TAD7 | PCDH19 | Protocadherin 19 | SP+TM | PM |
G1SQ59 | PHEX | Phosphate-regulating endopeptidase homolog X-linked | TM | CS † |
G1T949 | PORCN | Porcupine O-acyltransferase | TM | PM, ICPM † |
G1T7A1 | PTCHD1 | Patched domain-containing 1 | TM | PM † |
G1SZZ7 | RS1 | Retinoschisin 1 | SP | PM, ESPM, ES |
G1SZJ1 | SLC7A3 | Solute carrier family 7 member 3 | TM | PM † |
G1T4W3 | SLC9A6 | Sodium/hydrogen exchanger | SP+TM | PM † |
G1SLC9 | SLC9A7 | Sodium/hydrogen exchanger | SP+TM | PM |
G1T0T4 | SRPX2 | Sushi repeat containing protein X-linked 2 | SP | CS, PM, ES † |
G1SN13 | TENM1 | Teneurin transmembrane protein 1 | TM | PM, ICPM † |
O62852 | TRPC5 | Short transient receptor potential channel 5 | TM | PM |
A0A5F9CK03 | VSIG1 | V-set and immunoglobulin domain-containing protein 1 | SP+TM | PM † |
G1SR92 | XK | XK-related protein | TM | PM |
A0A5F9CW02 | - | Transmembrane protein 182 | TM | PM |
G1THX1 | - | Sodium/hydrogen exchanger | TM | PM |
G1TL60 | - | Olfactory receptor | TM | PM |
U3KP07 | - | receptor protein-tyrosine kinase | TM | PM |
Protein ID | Gene Name | Protein Name | Topology | GO Terms |
---|---|---|---|---|
Q9BYF1 | ACE2 | Angiotensin-converting enzyme 2 | SP+TM | CS, PM, ES †† |
Q8IZP9 | ADGRG2 | Adhesion G-protein-coupled receptor G2 | SP+TM | CS, PM † |
P50052 | AGTR2 | Type-2 angiotensin II receptor | TM | PM † |
Q99217 | AMELX | Amelogenin, X isoform | SP | CS † |
Q4VCS5 | AMOT | Angiomotin | GLOB | CS, PM, ESPM † |
P23352 | ANOS1 | Anosmin-1 | SP | CS, PM, ESPM, ES † |
Q9BUR5 | APOO | MICOS complex subunit MIC26 | TM | ES |
Q8NB49 | ATP11C | Phospholipid-transporting ATPase IG | TM | PM † |
Q9UN42 | ATP1B4 | Protein ATP1B4 | TM | PM |
Q16720 | ATP2B3 | Plasma membrane calcium-transporting ATPase 3 | TM | PM † |
Q15904 | ATP6AP1 | V-type proton ATPase subunit S1 | SP+TM | PM † |
O75787 | ATP6AP2 | Renin receptor | SP+TM | CS, PM, ESPM † |
Q04656 | ATP7A | Copper-transporting ATPase 1 | TM | PM† |
P30518 | AVPR2 | Vasopressin V2 receptor | TM | PM |
P51572 | BCAP31 | B-cell receptor-associated protein 31 | TM | PM, ICPM † |
P21810 | BGN | Biglycan | SP | CS, PM, ES † |
P32247 | BRS3 | Bombesin receptor subtype-3 | TM | PM † |
O60840 | CACNA1F | Voltage-dependent L-type calcium channel subunit alpha-1F | TM | PM † |
P29965 | CD40LG | CD40 ligand | TM | CS, PM, ESPM, ES † |
P14209 | CD99 | CD99 antigen | SP+TM | PM |
Q8TCZ2 | CD99L2 | CD99 antigen-like protein 2 | SP+TM | CS, PM † |
P51795 | CLCN5 | H(+)/Cl(−) exchange transporter 5 | TM | PM † |
P57739 | CLDN2 | Claudin-2 | TM | PM |
H7C241 | CLDN34 | Claudin-34 | TM | PM |
Q9HBJ8 | CLTRN | Collectrin | SP+TM | PM † |
A0A3B3IT09 | CLTRN * | Collectrin domain-containing protein | TM | PM |
Q16280 | CNGA2 | Cyclic nucleotide-gated olfactory channel | TM | PM |
Q9HC73 | CRLF2 | Cytokine receptor-like factor 2 | SP+TM | CS, PM, ESPM † |
P15509 | CSF2RA | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha | SP+TM | PM, ESPM † |
Q5H943 | CT83 | Kita-kyushu lung cancer antigen 1 | TM | PM |
P49682 | CXCR3 | C-X-C chemokine receptor type 3 | TM | CS, PM, ESPM † |
P04839 | CYBB | Cytochrome b-245 heavy chain | TM | PM, ICPM † |
Q9Y271 | CYSLTR1 | Cysteinyl leukotriene receptor 1 | TM | PM, ICPM † |
P11532 | DMD | Dystrophin | GLOB | CS, PM † |
Q92838 | EDA | Ectodysplasin-A | TM | PM, ES, ICPM † |
Q9HAV5 | EDA2R | Tumor necrosis factor receptor superfamily member 27 | TM | PM |
P98172 | EFNB1 | Ephrin-B1 | SP+TM | CS, PM † |
Q16206 | ENOX2 | Ecto-NOX disulfide-thiol exchanger 2 | GLOB | CS, PM, ESPM, ES † |
P34903 | GABRA3 | Gamma-aminobutyric acid receptor subunit alpha-3 | SP+TM | PM |
Q9UN88 | GABRQ | Gamma-aminobutyric acid receptor subunit theta | SP+TM | PM |
Q9HCC8 | GDPD2 | Glycerophosphoinositol inositolphosphodiesterase | TM | PM † |
P08034 | GJB1 | Gap junction beta-1 protein | TM | PM † |
P23416 | GLRA2 | Glycine receptor subunit alpha-2 | SP+TM | PM, ICPM † |
P51654 | GPC3 | Glypican-3 | SP | CS, PM, ACPM |
O75487 | GPC4 | Glypican-4 | SP | CS, PM, ESPM † |
Q13491 | GPM6B | Neuronal membrane glycoprotein M6-b | TM | PM † |
Q96P66 | GPR101 | Probable G-protein-coupled receptor 101 | TM | PM |
Q8TDV5 | GPR119 | Glucose-dependent insulinotropic receptor | TM | PM |
P51810 | GPR143 | G-protein-coupled receptor 143 | TM | PM † |
Q9NS66 | GPR173 | Probable G-protein-coupled receptor 173 | TM | PM |
Q9BXC1 | GPR174 | Probable G-protein-coupled receptor 174 | TM | PM |
Q9UPC5 | GPR34 | Probable G-protein-coupled receptor 34 | TM | PM |
Q13585 | GPR50 | Melatonin-related receptor | TM | PM † |
Q96P67 | GPR82 | Probable G-protein-coupled receptor 82 | TM | PM |
P42263 | GRIA3 | Glutamate receptor 3 | SP+TM | PM, ICPM † |
P30550 | GRPR | Gastrin-releasing peptide receptor | TM | PM, ICPM † |
P51841 | GUCY2F | Retinal guanylyl cyclase 2 | SP+TM | PM † |
Q9BQS7 | HEPH | Hephaestin | SP+TM | PM † |
P28335 | HTR2C | 5-hydroxytryptamine receptor 2C | SP+TM | CS, PM, ESPM, ICPM † |
P78552 | IL13RA1 | Interleukin-13 receptor subunit alpha-1 | SP+TM | PM, ESPM |
Q14627 | IL13RA2 | Interleukin-13 receptor subunit alpha-2 | SP+TM | ESPM, ES |
Q9NZN1 | IL1RAPL1 | Interleukin-1 receptor accessory protein-like 1 | SP+TM | CS, PM † |
Q9NP60 | IL1RAPL2 | X-linked interleukin-1 receptor accessory protein-like 2 | SP+TM | PM |
P31785 | IL2RG | Cytokine receptor common subunit gamma | SP+TM | CS, PM, ESPM † |
A0A2R8YE73 | IL2RG * | Fibronectin type-III domain-containing protein | SP+TM | CS, PM, ESPM † |
P26951 | IL3RA | Interleukin-3 receptor subunit alpha | SP+TM | PM, ESPM |
Q01113 | IL9R | Interleukin-9 receptor | SP+TM | PM, ESPM, ES |
P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | GLOB | CS, PM |
O43736 | ITM2A | Integral membrane protein 2A | TM | PM |
Q9NSA2 | KCND1 | Potassium voltage-gated channel subfamily D member 1 | TM | PM |
Q9UJ90 | KCNE5 | Potassium voltage-gated channel subfamily E regulatory beta subunit 5 | TM | PM, ICPM † |
P32004 | L1CAM | Neural cell adhesion molecule L1 | SP+TM | CS, PM, ESPM † |
P13473 | LAMP2 | Lysosome-associated membrane glycoprotein 2 | SP+TM | PM, ES † |
Q99677 | LPAR4 | Lysophosphatidic acid receptor 4 | TM | PM † |
Q9H0U3 | MAGT1 | Magnesium transporter protein 1 | SP+TM | PM |
Q8N4V1 | MMGT1 | ER membrane protein complex subunit 5 | TM | PM † |
Q8NHP6 | MOSPD2 | Motile sperm domain-containing protein 2 | TM | PM, ICPM † |
P26038 | MSN | Moesin | GLOB | CS, PM, ES † |
O75949 | NALF2 | NALCN channel auxiliary factor 2 | TM | PM |
Q00604 | NDP | Norrin | SP | CS, ES † |
Q9NZ94 | NLGN3 | Neuroligin-3 | SP+TM | CS, PM, ICPM † |
Q8N0W4 | NLGN4X | Neuroligin-4, X-linked | SP+TM | CS, PM, ICPM † |
Q9Y5S8 | NOX1 | NADPH oxidase 1 | TM | PM, ICPM † |
P04000 | OPN1LW | Long-wave-sensitive opsin 1 | TM | PM |
P04001 | OPN1MW | Medium-wave-sensitive opsin 1 | TM | PM |
P0DN77 | OPN1MW2 | Medium-wave-sensitive opsin 2 | TM | PM |
P0DN78 | OPN1MW3 | Medium-wave-sensitive opsin 3 | TM | PM |
Q8NG92 | OR13H1 | Olfactory receptor 13H1 | TM | PM |
O00398 | P2RY10 | Putative P2Y purinoceptor 10 | TM | PM |
P51582 | P2RY4 | P2Y purinoceptor 4 | TM | PM† |
Q86VZ1 | P2RY8 | P2Y purinoceptor 8 | TM | PM |
Q9BZA7 | PCDH11X | Protocadherin-11 X-linked | SP+TM | PM |
Q8TAB3 | PCDH19 | Protocadherin-19 | SP+TM | PM |
O00264 | PGRMC1 | Membrane-associated progesterone receptor component 1 | TM | PM |
P78562 | PHEX | Phosphate-regulating neutral endopeptidase PHEX | TM | CS, PM † |
P60201 | PLP1 | Myelin proteolipid protein | TM | PM † |
Q04941 | PLP2 | Proteolipid protein 2 | TM | PM † |
P51805 | PLXNA3 | Plexin-A3 | SP+TM | PM † |
Q9ULL4 | PLXNB3 | Plexin-B3 | SP+TM | CS, PM † |
Q9H237 | PORCN | Protein-serine O-palmitoleoyltransferase porcupine | TM | PM, ICPM † |
O14668 | PRRG1 | Transmembrane gamma-carboxyglutamic acid protein 1 | TM | PM, ES |
Q9BZD7 | PRRG3 | Transmembrane gamma-carboxyglutamic acid protein 3 | TM | ES |
Q96NR3 | PTCHD1 | Patched domain-containing protein 1 | TM | PM † |
O15537 | RS1 | Retinoschisin | SP | PM, ESPM, ES |
P36021 | SLC16A2 | Monocarboxylate transporter 8 | TM | PM, ICPM † |
O95258 | SLC25A14 | Brain mitochondrial carrier protein 1 | TM | PM |
P05141 | SLC25A5 | ADP/ATP translocase 2 | TM | PM |
Q8WUX1 | SLC38A5 | Sodium-coupled neutral amino acid transporter 5 | TM | PM |
Q9UN76 | SLC6A14 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | TM | PM |
P48029 | SLC6A8 | Sodium- and chloride-dependent creatine transporter 1 | TM | PM |
Q8WY07 | SLC7A3 | Cationic amino acid transporter 3 | TM | PM † |
Q92581 | SLC9A6 | Sodium/hydrogen exchanger 6 | SP+TM | PM † |
Q96T83 | SLC9A7 | Sodium/hydrogen exchanger 7 | SP+TM | PM |
Q9H156 | SLITRK2 | SLIT- and NTRK-like protein 2 | SP+TM | PM |
Q8IW52 | SLITRK4 | SLIT- and NTRK-like protein 4 | SP+TM | PM |
A6NGZ8 | SMIM9 | Small integral membrane protein 9 | SP+TM | PM |
P78539 | SRPX | Sushi repeat-containing protein SRPX | SP | CS |
O60687 | SRPX2 | Sushi repeat-containing protein SRPX2 | SP | CS, PM, ES † |
P08842 | STS | Steryl-sulfatase | SP+TM | PM |
P08247 | SYP | Synaptophysin | TM | PM † |
P51864 | TDGF1P3 | Putative teratocarcinoma-derived growth factor 3 | SP | CS, PM, ES † |
Q9UKZ4 | TENM1 | Teneurin-1 | TM | PM, ICPM † |
Q9NYK1 | TLR7 | Toll-like receptor 7 | SP+TM | PM † |
Q9NR97 | TLR8 | Toll-like receptor 8 | SP+TM | CS, PM, ESPM † |
Q9BQJ4 | TMEM47 | Transmembrane protein 47 | TM | PM † |
Q9UL62 | TRPC5 | Short transient receptor potential channel 5 | TM | PM |
P41732 | TSPAN7 | Tetraspanin-7 | TM | PM |
P51809 | VAMP7 | Vesicle-associated membrane protein 7 | TM | CS, PM † |
Q86XK7 | VSIG1 | V-set and immunoglobulin domain-containing protein 1 | SP+TM | PM † |
P55808 | XG | Glycoprotein Xg | SP+TM | PM, ICPM † |
P51811 | XK | Endoplasmic reticulum membrane adapter protein XK | TM | PM |
Q6PP77 | XKRX | XK-related protein 2 | TM | PM |
Protein ID | Gene Name | Protein Name | Topology | GO Terms |
---|---|---|---|---|
Q99218 | AMELY | Amelogenin, Y isoform | SP | CS † |
Q8NFZ3 | NLGN4Y | Neuroligin-4, Y-linked | SP+TM | CS, PM |
Q9BZA8 | PCDH11Y | Protocadherin-11, Y-linked | SP+TM | PM |
RefSeq_Human | RefSeq_Rabbit | Gene Name | Protein Description | Similarity (%) | Chromosome |
---|---|---|---|---|---|
XP_054183011 | XP_051689653 | ANOS1 | anosmin-1 | 59.2 | Unplaced |
XP_054183834 | XP_051683595 | APOO | MICOS complex subunit MIC26 | 85.4 | X |
XP_054182860 | XP_051687539 | ATP11C | phospholipid-transporting ATPase IG | 97.3 | Unplaced |
XP_016884870 | XP_008271374 | ATP1B4 | protein ATP1B4 | 87.0 | X |
XP_016885042 | XP_051693419 | ATP2B3 | plasma membrane calcium-transporting ATPase 3 | 90.5 | Unplaced |
NP_001174 | NP_001164848 | ATP6AP1 | V-type proton ATPase subunit S1 precursor | 90.4 | Unplaced |
NP_000045 | XP_008248538 | AVPR2 | vasopressin V2 receptor | 86.0 | Unplaced |
NP_001132929 | XP_008248542 | BCAP31 | B-cell receptor-associated protein 31 | 92.7 | Unplaced |
XP_054183538 | XP_051693405 | BGN | biglycan | 94.0 | Unplaced |
XP_047298518 | XP_008273252 | CD99L2 | CD99 antigen-like protein 2 | 76.5 | Unplaced |
NP_005131 | XP_051689801 | CNGA2 | cyclic nucleotide-gated olfactory channel | 94.0 | Unplaced |
XP_011544483 | XP_008273625 | CRLF2 | cytokine receptor-like factor 2 | 47.9 | Unplaced |
XP_047297804 | XP_008249542 | CSF2RA | granulocyte-macrophage colony-stimulating factor receptor subunit alpha | 49.6 | Unplaced |
NP_001017978 | XP_008271135 | CT83 | kita-kyushu lung cancer antigen 1 | 50.5 | X |
XP_006724531 | XP_051683632 | DMD | dystrophin | 94.6 | X |
XP_054182733 | XP_051689815 | GABRA3 | gamma-aminobutyric acid receptor subunit alpha-3 | 89.7 | Unplaced |
XP_011529486 | XP_002721381 | GABRQ | gamma-aminobutyric acid receptor subunit theta | 84.7 | Unplaced |
XP_054182809 | XP_002720349 | GPC3 | glypican-3 | 91.3 | X |
NP_473362 | XP_017205202 | GPR101 | probable G-protein-coupled receptor 101 | 84.8 | X |
NP_848566 | XP_002720339 | GPR119 | glucose-dependent insulinotropic receptor | 85.1 | X |
XP_054183230 | XP_008270867 | GPR173 | probable G-protein-coupled receptor 173 | 100.0 | X |
XP_005272654 | XP_002719905 | GPR34 | probable G-protein-coupled receptor 34 | 90.9 | X |
XP_011529518 | XP_008273247 | GPR50 | melatonin-related receptor | 74.7 | Unplaced |
XP_047297947 | XP_051682990 | GPR82 | probable G-protein-coupled receptor 82 | 90.8 | X |
XP_054183006 | XP_008271141 | IL13RA1 | interleukin-13 receptor subunit alpha-1 | 83.8 | X |
XP_054183007 | XP_051683230 | IL13RA2 | interleukin-13 receptor subunit alpha-2 | 65.7 | X |
XP_011529207 | XP_008271052 | IL1RAPL2 | X-linked interleukin-1 receptor accessory protein-like 2 | 95.4 | X |
XP_047298053 | XP_051693453 | IRAK1 | interleukin-1 receptor-associated kinase 1 | 82.7 | Unplaced |
NP_004970 | XP_002719951 | KCND1 | potassium voltage-gated channel subfamily D member 1 | 97.1 | X |
NP_000416 | XP_051693407 | L1CAM | neural cell adhesion molecule L1 | 91.3 | Unplaced |
NP_001116078 | XP_008271376 | LAMP2 | lysosome-associated membrane glycoprotein 2 | 84.2 | X |
XP_016884927 | XP_008271183 | LPAR4 | lysophosphatidic acid receptor 4 | 98.4 | X |
NP_001354845 | XP_008271178 | MAGT1 | magnesium transporter protein 1 | 97.3 | X |
NP_689794 | XP_051683552 | MOSPD2 | motile sperm domain-containing protein 2 | 88.0 | X |
XP_054182806 | XP_051683121 | NALF2 | NALCN channel auxiliary factor 2 | 86.7 | X |
NP_000504 | NP_001309193 | OPN1MW | medium-wave-sensitive opsin 1 | 87.9 | Unplaced |
XP_005274486 | XP_002724295 | P2RY8 | P2Y purinoceptor 8 | 78.9 | Unplaced |
XP_047297954 | XP_008271184 | P2RY10 | putative P2Y receptor family member 10 | 87.9 | X |
NP_006658 | XP_002720306 | PGRMC1 | membrane-associated progesterone receptor component 1 | 93.8 | X |
NP_000524 | XP_008271259 | PLP1 | myelin proteolipid protein | 99.6 | X |
NP_002659 | NP_001075566 | PLP2 | proteolipid protein 2 | 88.2 | X |
XP_047298203 | XP_008248506 | PLXNA3 | plexin-A3 | 88.5 | Unplaced |
NP_005384 | XP_017194059 | PLXNB3 | plexin-B3 | 89.0 | Unplaced |
NP_001135867 | XP_008270716 | PRRG1 | transmembrane gamma-carboxyglutamic acid protein 1 | 96.3 | X |
NP_006508 | XP_051691041 | SLC16A2 | monocarboxylate transporter 8 | 96.8 | Unplaced |
XP_011529704 | XP_008271409 | SLC25A14 | brain mitochondrial carrier protein 1 | 91.6 | X |
NP_001143 | XP_002720308 | SLC25A5 | ADP/ATP translocase 2 | 98.3 | X |
XP_054184094 | XP_051682846 | SLC38A5 | sodium-coupled neutral amino acid transporter 5 | 83.9 | X |
NP_009162 | XP_002720288 | SLC6A14 | sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | 90.8 | X |
NP_005620 | NP_001075866 | SLC6A8 | sodium- and chloride-dependent creatine transporter 1 | 97.5 | Unplaced |
XP_047298533 | XP_051687602 | SLITRK2 | SLIT and NTRK-like protein 2 | 98.3 | Unplaced |
XP_054182427 | XP_008271667 | SLITRK4 | SLIT and NTRK-like protein 4 | 98.1 | Unplaced |
NP_001156408 | XP_051691991 | SMIM9 | small integral membrane protein 9 | 69.7 | Unplaced |
XP_016885382 | XP_051682971 | SRPX | sushi repeat-containing protein SRPX, partial | 94.6 | X |
XP_047298063 | XP_008247483 | STS | steryl-sulfatase | 65.1 | Unplaced |
NP_003170 | XP_051682874 | SYP | synaptophysin | 79.8 | X |
NP_004606 | XP_017205349 | TSPAN7 | tetraspanin-7 | 99.2 | X |
XP_011529490 | XP_002722247 | VAMP7 | vesicle-associated membrane protein 7 | 66.3 | Unplaced |
XP_005274644 | XP_008271435 | XG | glycoprotein Xg | 47.8 | X |
XP_011529256 | XP_002720425 | XKRX | XK-related protein 2 | 91.2 | X |
Entry | Gene Name | Protein Name |
---|---|---|
Q9BYF1 | ACE2 *† | Angiotensin-converting enzyme 2 |
Q8IZP9 | ADGRG2 *† | Adhesion G-protein-coupled receptor G2 |
Q4VCS5 | AMOT *† | Angiomotin |
P23352 | ANOS1 | Anosmin-1 |
Q9BUR5 | APOO * | MICOS complex subunit MIC26 |
Q8NB49 | ATP11C | Phospholipid-transporting ATPase IG |
Q16720 | ATP2B3 | Plasma membrane calcium-transporting ATPase 3 |
Q15904 | ATP6AP1 | V-type proton ATPase subunit S1 |
O75787 | ATP6AP2 *† | Renin receptor |
Q04656 | ATP7A *† | Copper-transporting ATPase 1 |
P51572 | BCAP31 | B-cell receptor-associated protein 31 |
P21810 | BGN | Biglycan |
P32247 | BRS3 *† | Bombesin receptor subtype-3 |
O60840 | CACNA1F *† | Voltage-dependent L-type calcium channel subunit alpha-1F |
P51795 | CLCN5 *† | H(+)/Cl(−) exchange transporter 5 |
P57739 | CLDN2 *† | Claudin-2 |
Q9HC73 | CRLF2 | Cytokine receptor-like factor 2 |
Q5H943 | CT83 * | Kita-kyushu lung cancer antigen 1 |
P04839 | CYBB *† | Cytochrome b-245 heavy chain |
P11532 | DMD * | Dystrophin |
Q92838 | EDA *† | Ectodysplasin-A |
Q16206 | ENOX2 *† | Ecto-NOX disulfide-thiol exchanger 2 |
P34903 | GABRA3 | Gamma-aminobutyric acid receptor subunit alpha-3 |
Q9HCC8 | GDPD2 *† | Glycerophosphoinositol inositolphosphodiesterase GDPD2 |
P51654 | GPC3 * | Glypican-3 |
O75487 | GPC4 *† | Glypican-4 |
Q14627 | IL13RA2 * | Interleukin-13 receptor subunit alpha-2 |
Q9NZN1 | IL1RAPL1 *† | Interleukin-1 receptor accessory protein-like 1 |
P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 |
P32004 | L1CAM | Neural cell adhesion molecule L1 |
P13473 | LAMP2 * | Lysosome-associated membrane glycoprotein 2 |
Q9H0U3 | MAGT1 * | Magnesium transporter protein 1 |
Q8N4V1 | MMGT1 *† | ER membrane protein complex subunit 5 |
Q8NHP6 | MOSPD2 * | Motile sperm domain-containing protein 2 |
P26038 | MSN *† | Moesin |
Q00604 | NDP *† | Norrin |
Q9Y5S8 | NOX1 *† | NADPH oxidase 1 |
O00264 | PGRMC1 * | Membrane-associated progesterone receptor component 1 |
Q04941 | PLP2 * | Proteolipid protein 2 |
Q96NR3 | PTCHD1 *† | Patched domain-containing protein 1 |
O95258 | SLC25A14 * | Brain mitochondrial carrier protein 1 |
P05141 | SLC25A5 * | ADP/ATP translocase 2 |
Q9UN76 | SLC6A14 * | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) |
Q92581 | SLC9A6 *† | Sodium/hydrogen exchanger 6 |
Q9H156 | SLITRK2 | SLIT and NTRK-like protein 2 |
P78539 | SRPX * | Sushi repeat-containing protein SRPX |
P08842 | STS | Steryl-sulfatase |
P08247 | SYP * | Synaptophysin |
Q9UKZ4 | TENM1 *† | Teneurin-1 |
P41732 | TSPAN7 * | Tetraspanin-7 |
P51809 | VAMP7 | Vesicle-associated membrane protein 7 |
Q86XK7 | VSIG1 *† | V-set and immunoglobulin domain-containing protein 1 |
P51811 | XK *† | Endoplasmic reticulum membrane adapter protein XK |
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Pinto-Pinho, P.; Soares, J.; Esteves, P.; Pinto-Leite, R.; Fardilha, M.; Colaço, B. Comparative Bioinformatic Analysis of the Proteomes of Rabbit and Human Sex Chromosomes. Animals 2024, 14, 217. https://doi.org/10.3390/ani14020217
Pinto-Pinho P, Soares J, Esteves P, Pinto-Leite R, Fardilha M, Colaço B. Comparative Bioinformatic Analysis of the Proteomes of Rabbit and Human Sex Chromosomes. Animals. 2024; 14(2):217. https://doi.org/10.3390/ani14020217
Chicago/Turabian StylePinto-Pinho, Patrícia, João Soares, Pedro Esteves, Rosário Pinto-Leite, Margarida Fardilha, and Bruno Colaço. 2024. "Comparative Bioinformatic Analysis of the Proteomes of Rabbit and Human Sex Chromosomes" Animals 14, no. 2: 217. https://doi.org/10.3390/ani14020217