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Behav. Sci. 2014, 4(2), 125-153; doi:10.3390/bs4020125

Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders

1
Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Mayo Clinic, Jacksonville FL 32224, USA
2
Department of Psychiatry, University of Florida, Gainesville FL 32611, USA
*
Author to whom correspondence should be addressed.
Received: 6 March 2014 / Revised: 15 May 2014 / Accepted: 21 May 2014 / Published: 13 June 2014
(This article belongs to the Special Issue Management and Treatment of the Major Mental Disorders)
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Abstract

Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders. This review outlines data implicating NT in the pathophysiology and management of major mental disorders such as schizophrenia, drug addiction, and autism. The data suggest that NT receptor analogs have the potential to be used as novel therapeutic agents acting through modulation of neurotransmitter systems dys-regulated in these disorders. View Full-Text
Keywords: neurotensin; schizophrenia; antipsychotic drugs; addiction; autism spectrum disorder; animal models neurotensin; schizophrenia; antipsychotic drugs; addiction; autism spectrum disorder; animal models
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Boules, M.M.; Fredrickson, P.; Muehlmann, A.M.; Richelson, E. Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders. Behav. Sci. 2014, 4, 125-153.

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