The Brain Resting-State Functional Connectivity Underlying Violence Proneness: Is It a Reliable Marker for Neurocriminology? A Systematic Review
Abstract
:1. Introduction
2. Methods
Search Strategy
3. Results
3.1. Normative Population (Self-Reported Aggression)
3.2. Self-Reported Aggression Mediated by Genetic Markers
3.3. Mental Disorders (Self-Reported Aggression)
3.4. Laboratory Assessment of Aggression
3.4.1. Non-Violent Groups
3.4.2. Violent Group
4. Violent Populations
5. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Authors | Sample Characteristics | Age | Gender | Education | Drug Use | Handedness (Right/Left) | Violent Behavior Assessment | Methods of Analysis |
---|---|---|---|---|---|---|---|---|
Park et al. (2018) [34] | Healthy young children (n = 79) | 6.06 ± 0.96 | 49% ♂ 51% ♀ | - | - | - | Child Behavior Checklist | Seed-based |
Fulwiler et al. (2012) [35] | Healthy males (n = 16) | 34 ± 14.42 | ♂ | - | No current drug use | Right-handed | Spielberger State–Trait Anger Expression Inventory-2 | ROI |
Abram et al. (2015) [36] | Psychiatry healthy sample (n = 244) | 26 | 50% ♂ 50% ♀ | - | No current drug use | Right-handed | Externalizing Spectrum Inventory, brief form | ICA |
Klasen et al. (2018) [37] | Healthy young adults (n = 83) | 23.8 ± 3.6 | ♂ | - | - | Right-handed | Buss–Perry Aggression Questionnaire | ROI |
Kolla et al. (2018) [38] | Antisocial personality disorder subjects (n = 21) Controls (n = 19) | 36.2 ± 8.7 34.2 ± 7.7 | ♂ | - | No current drug use | - | Buss–Perry Aggression Questionnaire Reactive–Proactive Aggression Questionnaire | ROI |
Hoptman et al. (2010) [39] | Patients with schizophrenia or schizoaffective disorder (n = 25) Controls (n = 21) | 36.7 ± 10.5 40.4 ± 10.8 | 88% ♂ 12% ♀ 76% ♂ 24% ♀ | 12.3 ± 2.1 (years) 15.5 ± 3.0 (years) | CPZ equivalents | - | Buss Perry Aggression Questionnaire Life history of aggression Number total of arrests | ROI |
Wagner et al. (2018) [40] | Unmedicated female patients with BPD (n = 33) Controls (n = 33) | 26.7 ± 6.4 26.4 ± 6.2 | ♀ | 12.1 ± 1.6 (years) 11.8 ± 1.5 (years) | No current drug use | . | Buss–Perry Aggression Questionnaire | ROI |
Hasler et al. (2017) [41] | ADHD (n = 30) Controls (n = 15) | 38.7 ± 9.9 32.2 ± 5.5 | 70% ♂ 30% ♀ 26% ♂ 73% ♀ | - | 48h free of methylphenidate before fMRI | Right handed | Spielberger State–Trait Anger Expression Inventory-2 | CO2 challenge regressor |
McGlade et al. (2015) [42] | Veterans males with TBI (n = 24) Veterans females with TBI (n = 17) | 37.75 ± 9.59 40.0 ±11.15 | ♂ ♀ | 14.33 ± 2.10 (years) 15.06 ± 2.51 (years) | - | - | Buss–Perry Aggression QuestionnaireDisplaced Aggression Questionnaire | Seed-based |
Goswami et al. (2016) [43] | Retired athletes with a history of multiple concussions (n = 19); Controls (n = 17) | 50 ± 12 46 ± 10 | ♂ | 17 ± 1.8 16 ± 1.9 | No current drug use | - | Personality Assessment Inventory (aggression scale) | Seed-based |
Dailey et al. (2018) [44] | Adults with TBI (n = 17) Healthy controls (n = 17) | 21.86 ± 2.79 23.88 ± 3.26 | 26% ♂ 73% ♀ 29% ♂ 71% ♀ | - | - | - | Buss–Perry Aggression Questionnaire | ROI |
Gilam et al. (2017) [45] | Soldiers (n = 60) | 18.62 ± 0.88 | ♂ | > secondary education | No current drug use | Right-handed | Spielberger State–Trait Anger Expression Inventory Geneva Emotion Wheel | Brain functional parcellation |
Buades-Rotger et al. (2018) [46] | Healthy young women (n = 39) | 23.22 ± 3.2 | ♀ | - | No current drug use | Right-handed | Social Threat Aggression Paradigm | ROI |
Siep et al. (2018) [47] | Violent offenders (n = 18) Non-offender controls (n = 18) | 35.17 ± 7.12 37.06 ± 15.24 | ♂ | Current alcohol use No current drug use | - | - | Seed-based | |
Chen et al. (2015) [48] | Young violent offenders (n = 30) Controls (n = 29) | 16.06 ± 0.7 16.06 ± 0.4 | ♂ | 7.76 ± 2.2 10.06 ± 0.0 | - | Right-handed | - | ROI |
Leutgeb et al. (2016) [49] | Violent inmates of maximum security prison (n = 31) Controls (n = 30) | 36.8 ±12.0 35.1 ± 9.0 | ♂ | 11.3 ± 1.7 (years) 11.6 ± 1.0 (years) | Non-medicated | Right-handed | - | Seed-based |
Varkevisser et al. (2017) [50] | Impulsive and violent soldiers (n = 28) Controls (n = 30) | 36.54 ± 6.27 34.53 ± 7.59 | ♂ | 67,9% middle 53,3% middle | - | - | Interviews and criminal records | ROI |
Brain Structure (From) | Brain Structure (To) | Functional Connectivity | Aggression Assessment |
---|---|---|---|
Trait aggression | |||
Amygdala (bilateral) | Left mOFC | ⬇ | ⬆ Trait aggression |
vmPFC | ⬇ | ⬆ Trait aggression | |
Nucleus centralis superior (median raphe nucleus) | Frontopolar cortex (Brodmann area 10) | ⬇ | ⬆ Trait aggression |
vmPFC | Bilateral supramarginal gyrus | ⬇ | ⬆ Trait aggression |
Amygdala (right) | Inferior frontal gyrus (right) | ⬆ | ⬆ Trait aggression |
vmPFC | Angular gyrus (right) Posterior cingulated cortex Dorsomedial PFC | ⬆ | ⬆ Trait aggression |
Anger expression | |||
Amygdala (bilateral) | Left mOFC | ⬇ | ⬇ Anger control-out |
Hippocampus (right) | Parietal (supramarginal and angular gyrus) Frontal lobe (superior and middle frontal gyrus) | ⬆ | ⬆ Anger expression-out |
Proactive aggression | |||
Ventral striatal | Angular gyrus | ⬆ | ⬆ Proactive aggression |
Physical aggression | |||
OFC (left) | Left angular region | ⬇ | ⬆ Physical aggression |
Anterior insula | OFC | ⬇ | ⬆ Physical aggression ⬆ Destructive aggression |
Anterior insula | Ventral striatumAnterior cingulate cortex | ⬆ | ⬆ Physical aggression |
Revenge feelings | |||
Right OFC | Right cerebellum Right angular gyrus | ⬆ | ⬆ Revenge feelings |
Right OFC | Right midoccipital cortex | ⬆ | ⬇ Revenge feelings |
Laboratory task | |||
Amygdala basolateral | Left superior temporal gyrus | ⬆ | ⬆ Aggressive strategies (laboratory task) |
mOFC Superior parietal lobule | ⬇ | ⬆ Aggressive strategies (laboratory task) | |
Left mOFC | Left amygdala | ⬆ | Before emotional induction task (violent offenders) |
Left amygdala | Left uncus/amygdala Posterior insula | ⬇ | Before emotional induction task (violent offenders) |
Left mOFC | Left amygdala | ⬇ | After emotional induction task (violent offenders) |
Left amygdala | Right posterior insula Right superior temporal gyrus | ⬆ | After emotional induction task (violent offenders) |
Violent populations (no-self reported) | |||
Caudate nucleus (right) mPFC (right) Precuneus (left) | Adjacent structures | ⬇ | Young violent offenders |
Supramarginal gyrus (right) | Adjacent structures | ⬆ | Young violent offenders |
Right cerebellar hemisphere | Left amygdala | ⬆ | Violent inmates |
Bilateral cerebellar hemisphere | Bilateral OFC | ⬇ | Violent inmates |
Cerebellar vermis | Left OFC | ⬇ | Violent inmates |
Left dorsolateral PFC | Right dorsolateral PFC | ⬆ | Violent inmates |
Amygdala basolateral (bilateral) | Left dorsolateral PFC | ⬇ | Impulsive and aggressive group |
Left centromedial amygdala | Left fusiform gyrus Lingual gyrus | ⬆ | Impulsive and aggressive group |
Left anterior cingulate cortex | Left cuneus Left calcarine cortex Left superior occipital cortex | ⬆ | Impulsive and aggressive soldiers |
Right anterior cingulated cortex | Left cuneus Left precuneus Left calcarine cortex Left superior occipital cortex | ⬆ | Impulsive and aggressive soldiers |
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Romero-Martínez, Á.; González, M.; Lila, M.; Gracia, E.; Martí-Bonmatí, L.; Alberich-Bayarri, Á.; Maldonado-Puig, R.; Ten-Esteve, A.; Moya-Albiol, L. The Brain Resting-State Functional Connectivity Underlying Violence Proneness: Is It a Reliable Marker for Neurocriminology? A Systematic Review. Behav. Sci. 2019, 9, 11. https://doi.org/10.3390/bs9010011
Romero-Martínez Á, González M, Lila M, Gracia E, Martí-Bonmatí L, Alberich-Bayarri Á, Maldonado-Puig R, Ten-Esteve A, Moya-Albiol L. The Brain Resting-State Functional Connectivity Underlying Violence Proneness: Is It a Reliable Marker for Neurocriminology? A Systematic Review. Behavioral Sciences. 2019; 9(1):11. https://doi.org/10.3390/bs9010011
Chicago/Turabian StyleRomero-Martínez, Ángel, Macarena González, Marisol Lila, Enrique Gracia, Luis Martí-Bonmatí, Ángel Alberich-Bayarri, Rebeca Maldonado-Puig, Amadeo Ten-Esteve, and Luis Moya-Albiol. 2019. "The Brain Resting-State Functional Connectivity Underlying Violence Proneness: Is It a Reliable Marker for Neurocriminology? A Systematic Review" Behavioral Sciences 9, no. 1: 11. https://doi.org/10.3390/bs9010011