Ozone Exposure Controls Oxidative Stress and the Inflammatory Process of Hepatocytes in Murine Models
Abstract
:1. Introduction
2. Materials and Methods
2.1. Focus Question
2.2. Search Strategy
2.3. Eligibility Criteria
2.4. Data Extraction and Management
2.5. Bias Analysis
3. Results
3.1. Selection of PRISMA-Guided Studies
3.2. Animal Model Characteristics
3.3. Methods Used to Cause Liver Injury
3.4. Ozone Exposure Characteristics
3.5. Outcomes
3.5.1. Ozone Exposure and Metabolism Redox
3.5.2. Ozone Exposure and Inflammation
3.5.3. Secondary Outcomes
3.5.4. Risk of Bias and Methodological Quality Assessments
4. Discussion
4.1. Characteristics of the Study and the Animal Model
4.2. Intervention Characteristics
4.3. Ozone Exposure and Redox Metabolism and Inflammation Process
4.4. Ozone Exposure and Other Markers
4.5. Methodological Quality and Risk of Bias
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Oxidative Markers | Pro−Oxidant Enzymes | Antioxidant Markers | Infl. Cells | Infl. Mark | Morphologic Parameters | Other Analyzes | ||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MDA | H2O2 | PC | 4−HDA | CD (Conjugado dienos) | NOX(NADPH OXIDASE) | XOD | MPO | SOD | Cu, Zn−SOD | Mn−SOD | CAT | GSH | GST | GSSG | GPX | Kupfer Cell | Neutrofilos | TNF−α | IL−1β | Necrosis | Degeneration | Congestion | periportal Inflammation | Ca−ATPase | Ca2+ | Calpain | Phospholipase A | Lipofuscin | Lactate | ATP + ADP | Ácido Urico | Glicogênio | Neopttirna | AST | ALT | |
Laszczyca, et al., 1996 [14] | = | = | = | |||||||||||||||||||||||||||||||||
León, et al., 1998 [15] | − | + | = | + | + | − | − | |||||||||||||||||||||||||||||
Peralta, et al., 1999 [16] | − | + | + | − | − | − | − | − | ||||||||||||||||||||||||||||
Peralta, et al., 2000 [17] | − | − | + | − | − | |||||||||||||||||||||||||||||||
Jalil et al., 2001 [18] | − | + | = | − | − | + | ||||||||||||||||||||||||||||||
Ajamieh et al., 2002 [19] | − | − | − | − | − | − | − | |||||||||||||||||||||||||||||
Ajamieh et al., 2004 [20] | − | − | + | − | + | − | − | − | ||||||||||||||||||||||||||||
Ajamieh et al., 2005 [21] | − | + | − | + | − | + | − | − | − | − | ||||||||||||||||||||||||||
Zamora et al., 2005 [22] | − | − | + | + | − | |||||||||||||||||||||||||||||||
Madej et al., 2007 [23] | − | − | ||||||||||||||||||||||||||||||||||
Guanche et al., 2010 [24] | − | − | + | + | + | |||||||||||||||||||||||||||||||
Rodríguez et al., 2011 [25] | − | + | + | + | ||||||||||||||||||||||||||||||||
Gul et al., 2012 [26] | − | − | + | + | − | − | − | − | ||||||||||||||||||||||||||||
Gultekin et al., 2012 [27] | − | + | − | − | − | − | − | − | − | |||||||||||||||||||||||||||
Safwat et al., 2014 [28] | − | − | + | − | − | |||||||||||||||||||||||||||||||
Aslaner et al., 2015 [29] | − | − | + | − | − | − | − | − | − | − | − | |||||||||||||||||||||||||
Erdemli et al., 2019 [13] | − | − | + | + | ||||||||||||||||||||||||||||||||
Adali et al., 2019 [30] | − | − | − | − | − | |||||||||||||||||||||||||||||||
Guvendi et al., 2020 [5] | + |
+ | Increased |
− | Reduced |
= | Not effect |
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Pelinsari, S.M.; Sarandy, M.M.; Vilela, E.F.; Novaes, R.D.; Schlamb, J.; Gonçalves, R.V. Ozone Exposure Controls Oxidative Stress and the Inflammatory Process of Hepatocytes in Murine Models. Antioxidants 2024, 13, 212. https://doi.org/10.3390/antiox13020212
Pelinsari SM, Sarandy MM, Vilela EF, Novaes RD, Schlamb J, Gonçalves RV. Ozone Exposure Controls Oxidative Stress and the Inflammatory Process of Hepatocytes in Murine Models. Antioxidants. 2024; 13(2):212. https://doi.org/10.3390/antiox13020212
Chicago/Turabian StylePelinsari, Silvania Mol, Mariáurea Matias Sarandy, Emerson Ferreira Vilela, Rômulo Dias Novaes, Jade Schlamb, and Reggiani Vilela Gonçalves. 2024. "Ozone Exposure Controls Oxidative Stress and the Inflammatory Process of Hepatocytes in Murine Models" Antioxidants 13, no. 2: 212. https://doi.org/10.3390/antiox13020212