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Vaccines 2014, 2(1), 112-128; doi:10.3390/vaccines2010112

Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention

Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
Departments of Microbiology and Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Author to whom correspondence should be addressed.
Received: 2 December 2013 / Revised: 18 January 2014 / Accepted: 6 February 2014 / Published: 14 February 2014
(This article belongs to the Special Issue Pneumococcal Vaccine in the 21st Century)
View Full-Text   |   Download PDF [336 KB, uploaded 14 February 2014]


Seven-valent pneumococcal conjugate vaccine (PCV7) introduction and routine pediatric use has substantially reduced the burden of Streptococcus pneumoniae disease worldwide. However, a significant amount of disease burden, due to serotypes not contained in PCV7, still exists globally. A newly recognized serotype, 6C, was until recently, identified and reported as serotype 6A. This review summarizes the serotype epidemiology of pneumococcal disease pre- and post-introduction of PCV7, available post-marketing surveillance data following the introduction of higher valency pneumococcal vaccines (PCV10, PCV13) and future prospects for the development of new pneumococcal vaccines.
Keywords: Streptococcus pneumoniae; vaccine; epidemiology; serotype; pneumococcal protein Streptococcus pneumoniae; vaccine; epidemiology; serotype; pneumococcal protein
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lee, L.H.; Gu, X.-X.; Nahm, M.H. Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention. Vaccines 2014, 2, 112-128.

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