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Journal of Clinical Medicine, Volume 15, Issue 9

2026 May-1 - 382 articles

Cover Story: Fertility preservation protects reproductive potential in patients receiving gonadotoxic therapy. Centralized ovarian cryobanking uses overnight tissue transport in 4–8 °C HTK solution, with unclear molecular impacts. This prospective study included 36 breast cancer patients. We compared RNA‑seq of biopsies after overnight hypothermic transport + slow freezing versus direct freezing within 2 hours. Only six genes were upregulated (H2B, MT‑ND6), showing minimal transcriptional change. qPCR validated H2B upregulation; MT‑ND6 remained stable. We first confirmed MT‑ND6 protein in human ovarian tissue. Subtle chromatin and mitochondrial changes were found. No apoptosis‑related gene shifts occurred within 24 hours, confirming tissue stability. The findings support centralized ovarian cryobanking with overnight HTK transport. View this paper
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Articles (382)

  • Article
  • Open Access
819 Views
15 Pages

Survival Outcomes of Open Versus Robot-Assisted Radical Cystectomy: A Large-Scale Multicenter Propensity Score Matched Study

  • Jong Ho Park,
  • Sangchul Lee,
  • Seung-Hwan Jeong,
  • Ja Hyeon Ku,
  • Kyung Hwan Kim,
  • Jong Kil Nam,
  • Bumjin Lim,
  • BumSik Hong,
  • Wook Nam and
  • Jong Jin Oh
  • + 11 authors

Background/Objectives: While robot-assisted radical cystectomy (RARC) is widely adopted, its long-term survival impact relative to open radical cystectomy (ORC) remains uncertain. We compared survival outcomes between ORC and RARC using a propensity...

(This article belongs to the Special Issue Innovations in Surgical and Medical Approaches of Urologic Oncology)
  • Article
  • Open Access
2 Citations
742 Views
22 Pages

Systemic Inflammatory and Hematologic Biomarkers in Pediatric Dental Caries: Clear Group Differences with Limited Independent Association with DMFT

  • Ștefania Alice Petrache,
  • Mihail Virgil Boldeanu,
  • Oana Andreea Diaconu,
  • Adelina Smaranda Bugălă,
  • Mădălina Olteanu,
  • Ionela Teodora Dascălu,
  • Andreea Gabriela Nicola,
  • Maria Cristina Beznă,
  • Marilena Bătăiosu and
  • Mihaela Jana Țuculină

Background: Dental caries in children has been explored not only as a local oral condition but also in relation to potential systemic inflammatory changes. This study evaluated systemic inflammatory biomarkers and hematologic indices in children with...

(This article belongs to the Special Issue Oral Health and Dental Care: Current Advances and Future Options)
  • Article
  • Open Access
626 Views
13 Pages

Low HPV16 E6 Seroprevalence in HNSCC: A Prospective Study in Brazil

  • Enes Buck Mutiua Cantala Xavier,
  • Camila Batista Daniel,
  • Priscila Marinho de Abreu,
  • Isabella Bittencourt do Valle,
  • Brena Ramos Athaydes,
  • Frederico Firme Figueira,
  • Agenor Sena,
  • Evandro Duccini de Souza,
  • Tim Waterboer and
  • Sandra Ventorin von Zeidler

Background/Objectives: Head and neck squamous cell carcinoma (HNSCC) remains a global public health challenge with significant morbidity and mortality. Emerging epidemiological data indicate a rising global incidence of human papillomavirus (HPV)-rel...

(This article belongs to the Section Oncology)
  • Feature Paper
  • Article
  • Open Access
592 Views
13 Pages

Suture Versus Non-Suture Closure of the Cystic Duct Orifice During Fenestrating Laparoscopic Subtotal Cholecystectomy: A Single-Center Retrospective Study

  • Hiroto Sakurai,
  • Kei Nakagawa,
  • Shingo Tsujinaka,
  • Kenichiro Yambe,
  • Kazuhiro Takami,
  • Noriko Kondo,
  • Kuniharu Yamamoto,
  • Chikashi Shibata and
  • Yu Katayose

Background/Objectives: Laparoscopic subtotal cholecystectomy (LSC) can be performed using either the fenestrating or reconstituting method. In the fenestrating method, some surgeons additionally perform suture closure of the cystic duct orifice, wher...

(This article belongs to the Special Issue Approaches to Prevention and Management of Postoperative Complications in Minimally Invasive Surgery)
  • Article
  • Open Access
1 Citations
598 Views
15 Pages

Artificial Intelligence vs. Human Readers in Contrast-Enhanced Harmonic Imaging Endoscopic Ultrasound Interpretation of Solid Pancreatic Masses: A Multicenter Interobserver Study

  • Nicoleta Podină,
  • Lucian Gheorghe Gruionu,
  • Anca Udriștoiu,
  • Elena Codruța Gheorghe,
  • Voicu Rednic,
  • Alina Liliana Constantin,
  • Maria Simona Badiu,
  • Cristian George Țieranu,
  • Nona Bejinariu and
  • Adrian Săftoiu
  • + 3 authors

Background/Objectives: Contrast-enhanced harmonic imaging endoscopic ultrasound (CHI-EUS) is a valuable tool for characterizing solid pancreatic tumors. However, interobserver variability remains a significant limitation in clinical interpretation. A...

(This article belongs to the Special Issue Pancreatic Disorder, Pancreatitis, and Pancreatic Cancer: Interconnections, Clinical Challenges, and Therapeutic Advances)
  • Article
  • Open Access
463 Views
12 Pages

Clinicopathological Characteristics of Acute Antibody-Mediated Rejection in Pediatric Liver Transplantation—A Single-Center Study

  • Sylwia Szymanska,
  • Barbara Piątosa,
  • Mateusz Ciopiński,
  • Artur Kijewski,
  • Piotr Kaliciński and
  • Małgorzata Markiewicz-Kijewska

Introduction: Presently, liver transplantation is becoming a more common treatment option for adults and children suffering from liver failure. Antibody-mediated rejection (AMR), a phenomenon that is exceedingly uncommon and inadequately comprehended...

(This article belongs to the Special Issue Clinical Advances in Pediatric Critical Care Medicine)
  • Article
  • Open Access
599 Views
15 Pages

Peripapillary Vessel Density Mediates the Relationship Between Axial Length and Visual Field Damage in Glaucoma

  • Samuel Potash,
  • Alon Harris,
  • Alice Verticchio Vercellin,
  • Keren Wood,
  • Gal Yaakov Cohen,
  • Adam Rosen,
  • Minwoo Kwon,
  • Jacob Rothstein,
  • Yash Lahoti and
  • Brent A. Siesky
  • + 2 authors

Objectives: Axial myopia is a risk factor for glaucoma, yet the mechanism(s) linking axial length (AL) to visual field (VF) damage remain unclear. This pilot study investigates to what extent peripapillary vessel density (pVD) mediates the relationsh...

(This article belongs to the Special Issue Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies)
  • Article
  • Open Access
1 Citations
597 Views
13 Pages

Evaluating Dry Eye Disease Subtypes Based on Whole-Area Lipid Layer Thickness Assessment

  • Hyunmin Ahn,
  • Young Joon Choi,
  • Ikhyun Jun,
  • Tae-im Kim and
  • Kyoung Yul Seo

Background/Objectives: Lipid layer thickness (LLT) is widely used to assess tear film status in dry eye disease (DED), but single-point measurements may not adequately reflect spatial lipid distribution driven by tear film dynamics. This study evalua...

(This article belongs to the Special Issue Meibomian Gland Dysfunction and Dry Eye Diseases)
  • Article
  • Open Access
1 Citations
480 Views
17 Pages

Pre-Transplant Prognostic Nutritional Index Independently Predicts Progression-Free Survival After Autologous Stem Cell Transplantation in Lymphoma

  • Hüseyin Atacan,
  • Volkan Aslan,
  • Alper Topal,
  • Nurlan Mammadzada,
  • Gizem Yıldırım,
  • Gökçe Gül Güneysu,
  • Berkan Karadurmuş,
  • Esmanur Kaplan Tüzün,
  • Ömer Faruk Kuzu and
  • Nuri Karadurmuş
  • + 3 authors

Background: Autologous stem cell transplantation (ASCT) is a standard treatment for relapsed or high-risk lymphoma. While disease-related factors are well-known, the impact of host-related factors like nutritional status remains less defined. We aime...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
743 Views
12 Pages

Clinical Characteristics and Treatment Outcomes of Pediatric Glaucoma: A Retrospective Cohort Study

  • Nancy N. Hanna,
  • Doris Canes Napoles,
  • Aaron Flickinger,
  • Carter L. Carlos,
  • Richard W. Hertle and
  • Xiaoming Gong

Objectives: This study aimed to evaluate clinical characteristics and treatment outcomes in a cohort of pediatric patients with glaucoma over 10-year period at a tertiary referral center. Methods: Medical records of patients younger than 18 years dia...

(This article belongs to the Special Issue Clinical Outcomes of Glaucoma Surgery: Visual Acuity, Effectiveness and Quality of Life)
  • Case Report
  • Open Access
662 Views
13 Pages

Phenotypic Heterogeneity in Titinopathies with Peripheral Nerve Involvement in Pediatric Age: Two Case Reports

  • Carlo Alberto Cesaroni,
  • Giulia Pisanò,
  • Massimiliano Marton,
  • Stefano Giuseppe Caraffi,
  • Susanna Rizzi,
  • Agnese Pantani,
  • Diletta Ziveri,
  • Marzia Pollazzon,
  • Juha Koskenvuo and
  • Carlo Fusco
  • + 1 author

Background/Objectives: Titin (TTN; OMIM 188840) is the largest known human sarcomeric protein, and pathogenic variants in the TTN gene cause a broad spectrum of inherited myopathies and cardiomyopathies. The extent to which TTN variants may also invo...

(This article belongs to the Section Clinical Pediatrics)
  • Review
  • Open Access
825 Views
18 Pages

Background/Objectives: Chronic obstructive pulmonary disease (COPD) management increasingly relies on patient self-management; however, medication non-adherence, inhaler misuse, delayed exacerbation recognition, and suboptimal engagement in pulmonary...

(This article belongs to the Special Issue Advances in the Management and Understanding of Adult Respiratory Diseases)
  • Review
  • Open Access
539 Views
21 Pages

A Scoping Review of Gut Dysbiosis and Malnutrition in Neurological Disorders: Implications, Indications, and Promising Therapeutic Approaches

  • Thana’ Aljaraedah,
  • Sameeha Al-Thnaibat,
  • Abd Al-Rhman Nawasreh,
  • Wesal Alraei and
  • Esra’a Al-Trad

Background/Objectives: Neurological diseases are increasing worldwide, but the biological processes underlying these diseases remain poorly understood, and existing treatments have been ineffective at arresting disease progression. Emerging data indi...

(This article belongs to the Topic Environmental Influences on Dietary Patterns and Disease Risk: Nutritional Pathways and Health Implications)
  • Article
  • Open Access
1,201 Views
11 Pages

Atherosclerosis Progression Evaluation in Coronary Arteries by Computed Tomography Compared to Peripheral Vessels Using 3D Ultrasonography

  • Maria Noflatscher,
  • Michael Schreinlechner,
  • Philip Sommer,
  • Julian Freiberger,
  • Fabian Plank,
  • Pietro G. Lacaita,
  • Markus Theurl,
  • Rudolf Kirchmair,
  • Axel Bauer and
  • Peter Marschang
  • + 1 author

Background: Cardiovascular disease remains the leading cause of mortality worldwide. In recent years, several non-invasive imaging techniques have been introduced to improve the assessment of atherosclerotic burden and cardiovascular risk, including...

(This article belongs to the Section Nuclear Medicine & Radiology)
  • Review
  • Open Access
2 Citations
1,309 Views
29 Pages

Percutaneous Cryoneurolysis for Upper Limb Spasticity: A Systematic Scoping Review of Current Evidence, Safety Profile, and Implications for Hand and Upper Extremity Practice

  • Marco Passiatore,
  • Luciano Maria Bissolotti,
  • Marta Starnoni,
  • Luca Pecori,
  • Anna Paola D’Apolito,
  • Francesco De Santis and
  • Rocco De Vitis

Background/Objectives: Percutaneous cryoneurolysis (CNL) has emerged as a minimally invasive neuromodulatory technique for focal spasticity management, with growing international clinical adoption since 2018. Its application to upper limb motor nerve...

(This article belongs to the Special Issue Innovation in Hand Surgery)
  • Article
  • Open Access
504 Views
13 Pages

Background: Parkinson’s Disease is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. Effective management is critical to improving patient outcomes but is limited by the subjectivity of retrospective assess...

(This article belongs to the Special Issue Innovations in Parkinson’s Disease)
  • Article
  • Open Access
836 Views
16 Pages

Personality Disorders in Functional and Idiopathic Dystonia

  • Violetta Aleksandrovna Tolmacheva,
  • Vladimir Anatolyevich Parfenov,
  • Dmitry Vladimirovich Romanov,
  • Ekaterina Dmitrievna Spektor,
  • Beatrisa Albertovna Volel and
  • Ekaterina Vladimirovna Silina

Background: Distinguishing functional dystonia (FD) from idiopathic dystonia (ID) remains a major clinical challenge because both conditions are diagnosed primarily on clinical grounds and may be accompanied by non-motor psychiatric symptoms. Althoug...

(This article belongs to the Special Issue Neuro-Psychiatric Disorders: Updates on Diagnosis and Treatment—2nd Edition)
  • Review
  • Open Access
3 Citations
3,171 Views
20 Pages

Aortopathy in Bicuspid Aortic Valve: Pathophysiology, Risk Stratification and Surgical Decision-Making—A Narrative Review

  • Sebastian Krych,
  • Julia Gniewek,
  • Michał Jurkiewicz,
  • Paweł Kowalczyk,
  • Dariusz Waniczek and
  • Tomasz Hrapkowicz

Bicuspid aortic valve (BAV) is one of the most common congenital heart defects, introducing significant hemodynamic disturbances to the circulatory system. This narrative review analyzed articles published between 2012 and 2025 and indexed in PubMed....

(This article belongs to the Special Issue Global Expert Views on Aortic Valve Repair and Replacement: 2nd Edition)
  • Systematic Review
  • Open Access
695 Views
16 Pages

Safety and Efficiency of Various Pancreatic Enucleation Procedures: A Systematic Review and Meta-Analysis

  • Deqiang Zhou,
  • Feng Tan,
  • Zihe Wang,
  • Ning Xia,
  • Xing Huang,
  • Li Wang,
  • Shijie Cai,
  • Bole Tian and
  • Junjie Xiong

Objective: This study aimed to systematically compare the short-term outcomes of minimally invasive pancreatic enucleation (MI-pEn), including laparoscopic and robotic-assisted approaches, and open pancreatic enucleation (O-pEn). Methods: A systemati...

(This article belongs to the Section General Surgery)
  • Article
  • Open Access
1 Citations
755 Views
20 Pages

Real-World Data on Halting Radiographic Progression with Antifibrotics in Connective Tissue Disease-Associated Interstitial Lung Disease: A Two-Center Study from Hungary

  • Zsuzsanna Gyetkó,
  • Edit Végh,
  • Dóra Nemes-Tömöri,
  • Lilla Andó,
  • Edit B. Nagy,
  • Judit Maráz,
  • Angéla Mikáczó,
  • Anna Sárközi,
  • Ildikó Horváth and
  • Szilvia Szamosi
  • + 6 authors

Background/Objectives: Connective tissue disease-associated interstitial lung disease (CTD-ILD) is linked to substantial morbidity and mortality. While nintedanib (NTB) slows lung function decline in progressive pulmonary fibrosis (PPF), real-world d...

(This article belongs to the Section Immunology & Rheumatology)
  • Article
  • Open Access
631 Views
15 Pages

Background/Objectives: Accurate quantification of left-to-right shunt volume is central to clinical decision-making in patients with atrial septal defect (ASD). Conventional echocardiographic Qp:Qs estimation is widely used but limited by operator de...

(This article belongs to the Special Issue Management of Congenital Heart Disease (CHD))
  • Review
  • Open Access
908 Views
18 Pages

Functionally single-ventricle (FSV) defects are complex congenital heart anomalies that require Fontan palliation, a surgical procedure redirecting systemic venous blood directly to the pulmonary arteries, bypassing the heart. Despite improvements in...

(This article belongs to the Special Issue Congenital Heart Disease in Adults (ACHD): Diagnosis, Therapy, and Clinical Management)
  • Article
  • Open Access
660 Views
10 Pages

Use of Novel 6.3 Fr Ureteroscope in Endoscopic Combined Intrarenal Surgery (ECIRS): Comparative Experience with Conventional Ureteroscopes

  • Theodoros Spinos,
  • Vasileios Tatanis,
  • Angelis Peteinaris,
  • Fani Moultsia,
  • Dimitrios Diamantopoulos Kogkas,
  • Paraskevi Katsakiori,
  • Vasiliki Tsekoura,
  • Theofanis Vrettos,
  • Evangelos Liatsikos and
  • Panagiotis Kallidonis

Background/Objectives: Recently, a 6.3 Fr single-use flexible ureteroscope (f-URS) was introduced to the market. The purpose of this pilot study is to present our experience with it during Endoscopic Combined Intrarenal Surgery (ECIRS) and to compare...

(This article belongs to the Section Nephrology & Urology)
  • Systematic Review
  • Open Access
981 Views
24 Pages

Antipsychotic Drugs and the Risk of Diabetic Complications: A Systematic Review of Observational Studies

  • Nisrine Haddad,
  • Nawal Farhat,
  • Christopher A. Gravel,
  • Yue Chen,
  • Franco Momoli,
  • Donald R. Mattison,
  • Jeannette Goguen and
  • Daniel Krewski

Background: In recent years, case reports and case series have suggested an association between the use of second- (SGAs), but not first-generation antipsychotics (FGAs), also known as atypical and typical APDs, respectively, and hyperglycemic compli...

(This article belongs to the Section Pharmacology)
  • Article
  • Open Access
788 Views
14 Pages

Contrast-Associated Acute Kidney Injury and Mortality Risk After Coronary Angiography for Acute Coronary Syndromes: A Retrospective Cohort Study

  • Eva Maria Olivas-Flores,
  • Alberto Daniel Rocha-Muñoz,
  • Angelita del Socorro Valencia-López,
  • Roberto Rojas-Castillo,
  • Jorge Guillermo Delgado-Gutiérrez,
  • Karina Patricia Pizarro-Gonzales,
  • Mario Alberto Mireles-Ramírez,
  • J. Ahuixotl Gutiérrez-Aceves,
  • Nicte Selene Fajardo-Robledo and
  • Laura Gonzalez-Lopez
  • + 7 authors

Background/Objectives: Contrast-associated acute kidney injury (CA-AKI) is a frequent complication after coronary angiography (CAG) that may adversely affect outcomes in patients with acute coronary syndrome (ACS). We aimed to estimate the incidence...

(This article belongs to the Section Cardiovascular Medicine)
  • Article
  • Open Access
838 Views
13 Pages

Hidden Burden of Hypertension in Türkiye: A Multi-Center DAHUDER World Hypertension Day Study Reveals Gaps in Awareness, Adherence, and Control

  • Hilmi Erdem Sumbul,
  • Ihsan Solmaz,
  • Esref Arac,
  • Ismail Demir,
  • Seyit Uyar,
  • Kamil Konur,
  • Ersin Kuloglu,
  • Ahmed Bilal Genc,
  • Celalettin Kucuk and
  • Ramazan Azim Okyay
  • + 12 authors

Background: Hypertension remains the single most important modifiable risk factor for cardiovascular disease, stroke, and premature mortality worldwide. Despite major pharmacological advances, awareness, treatment, and control rates remain globally i...

(This article belongs to the Section Cardiovascular Medicine)
  • Article
  • Open Access
563 Views
17 Pages

Background/Objectives: Dyspnoea in heart failure with reduced or mildly reduced ejection fraction (HFrEF/HFmrEF) is multidimensional, yet conventional unidimensional scales do not capture its sensory and affective components. The Multidimensional Dys...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
502 Views
14 Pages

Background: Outpatient palliative care effectively alleviates symptom burden in advanced cancer patients, yet data from Central–Eastern Europe remain scarce. This retrospective study examined changes in revised Edmonton Symptom Assessment Scale...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
2 Citations
658 Views
12 Pages

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease in which accurate assessment of disease activity remains challenging. Although composite indices such as BASDAI and ASDAS are widely used, they may not fully capture systemic i...

(This article belongs to the Section Immunology & Rheumatology)
  • Systematic Review
  • Open Access
1,204 Views
17 Pages

Therapeutic Efficacy of Hyperbaric Oxygen in Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis

  • Hani Basher ALBalawi,
  • Moustafa S. Magliyah,
  • Naif M. Alali,
  • Mohammed M. Alshehri,
  • Abdullah Alhewiti,
  • Faisal Almarek,
  • Ibrahim Shajry,
  • Mohammad A. Hazzazi and
  • Yousef A. Alotaibi

Background/Objectives: Central retinal artery occlusion (CRAO) is a vision-threatening condition with limited evidence-based treatment options. Hyperbaric oxygen therapy (HBOT) has emerged as a potential intervention, but its efficacy remains debated...

(This article belongs to the Special Issue Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies)
  • Article
  • Open Access
825 Views
12 Pages

Clinical Outcomes of Insulin Glargine U300 on Glycemic Control and Hypoglycemia: A Retrospective Observational Study

  • Gökçen Güngör Semiz,
  • Mehmet Çağrı Ünal,
  • İsmail Selimoğlu,
  • Sıla Kalender,
  • Ege Erbay,
  • Mehmet Emin Arayici,
  • Abdurrahman Çömlekçi,
  • Serkan Yener and
  • Tevfik Demir

Background/Objectives: Insulin glargine U300 (IGlarU300) is a second-generation, long-acting insulin analog designed to provide a more stable pharmacokinetic profile compared to insulin glargine U100. However, long-term real-world data reflecting its...

(This article belongs to the Special Issue Clinical Advances in Diabetes, Obesity, and Hypertension)
  • Article
  • Open Access
611 Views
16 Pages

Three-Year Outcomes and Safety of the XEN63 Gel Stent: A Multicenter Prospective Study in Primary Open-Angle Glaucoma

  • José María Martínez-de-la-Casa,
  • María Teresa Marcos-Parra,
  • Elena Millá-Griñó,
  • Teresa Laborda,
  • Rafael Giménez,
  • José Manuel Larrosa,
  • Aritz Urcola,
  • Miguel Ángel Teus and
  • Susana Perucho-Martínez

Purpose: To evaluate the 3-year effectiveness and safety of the XEN63 Gel Stent, both as a standalone procedure and combined with phacoemulsification, in patients with primary open-angle glaucoma (POAG). Methods: This prospective, multicenter, non-ra...

(This article belongs to the Section Ophthalmology)
  • Review
  • Open Access
673 Views
17 Pages

Applications of Photopic Negative Response: A Narrative Review

  • Minzhong Yu,
  • Nara Shakaki and
  • Anas Bakdalieh

Background: The photopic negative response (PhNR) of the full-field electroretinogram is a retinal ganglion cell-weighted functional signal increasingly proposed as a clinical biomarker. Despite extensive study across ocular and systemic diseases, it...

(This article belongs to the Special Issue Ocular Surface, Retina, and Choroid as Mirrors of Systemic and Genetic Diseases)
  • Feature Paper
  • Article
  • Open Access
1,033 Views
12 Pages

Analysis of Clinical Characteristics of Patients with Systemic Sclerosis and Gastric Antral Vascular Ectasia

  • Claudia Codina-Clavaguera,
  • Luis Gerardo Alcala-Gonzalez,
  • Laura Triginer-Gil,
  • Alejandra Fernandez-Luque,
  • Francisco-Alejandro Félix-Téllez,
  • Maria Teresa Sanz-Martínez,
  • Laura Viñas-Giménez,
  • Janire Perurena-Prieto,
  • Alfredo Guillen-Del-Castillo and
  • Carmen P. Simeón-Aznar

Background/Objectives: Gastric antral vascular ectasia (GAVE) is a gastrointestinal manifestation associated with systemic sclerosis (SSc) that can lead to significant morbidity. This study aimed to characterise and compare the clinical profiles, lab...

(This article belongs to the Special Issue News in the Pathogenesis, Diagnosis and Treatment of Systemic Sclerosis)
  • Article
  • Open Access
963 Views
28 Pages

Background/Objectives: Placental abruption remains one of the leading causes of maternal morbidity, and the development of disseminated intravascular coagulation (DIC) significantly worsens outcomes. We sought to develop and internally validate a pre...

(This article belongs to the Special Issue Pregnancy Complications and Maternal-Perinatal Outcomes)
  • Brief Report
  • Open Access
542 Views
8 Pages

Preliminary Experience with New Dual-Mobility System for Small Japanese Patients

  • Kenji Kawate,
  • Tomohiro Teranishi,
  • Yumiko Kondo,
  • Mitsumasa Matsui and
  • Shinji Ueno

Background/Objectives: The preliminary experience with new dual-mobility system for small Japanese patients was introduced in this paper. Methods: Twenty-nine hips which underwent primary THA were retrospectively reviewed. All cups were inserted via...

(This article belongs to the Special Issue New Advances in Hip and Knee Arthroplasty)
  • Article
  • Open Access
549 Views
19 Pages

Prevalence and Distribution of Axis Subtypes of Refractive Astigmatism in Mexican Outpatients: A Nationwide Multicenter Clinic-Based Cross-Sectional Study

  • José Antonio Magaña-Lizárraga,
  • Abraham García-Gil,
  • Ricardo Daniel Contreras-Espinoza,
  • Eduardo Espinoza-Angulo,
  • Héctor Machado-Jiménez,
  • Marco Antonio Luna-Ruiz-Esparza,
  • Humberto Gómez-Campaña,
  • Abraham Campos-Romero and
  • Jonathan Alcántar-Fernández

Background/Objectives: Astigmatism is one of the most common refractive errors and represents a risk factor for other ocular conditions, including myopia and amblyopia. In Mexico, comprehensive epidemiological data on refractive astigmatism, particul...

(This article belongs to the Section Epidemiology & Public Health)
  • Review
  • Open Access
1,133 Views
25 Pages

Systematic Echocardiographic Assessment of the Univentricular Heart Across the Stages of Fontan Palliation: A Practical Guide with Focus on Emerging 3D and 4D Imaging Modalities and Thromboembolic Complications from AEPC Imaging Working Group

  • Massimiliano Cantinotti,
  • Pietro Marchese,
  • Giovanni Di Salvo,
  • Nadia Assanta,
  • Guglielmo Capponi,
  • Inga Voges,
  • Francesca Raimondi,
  • Almudena Ortiz Garrido,
  • Sylvia Krupickova and
  • Colin J. McMahon
  • + 5 authors

Although echocardiography remains the primary imaging modality for assessing Fontan palliation, a standardized systematic approach for evaluating the univentricular heart throughout the different stages of palliation has yet to be established. This d...

(This article belongs to the Section Hematology)
  • Article
  • Open Access
718 Views
13 Pages

Background and Objectives: Idiopathic pulmonary fibrosis (IPF) is frequently accompanied by chronic cough, which may negatively affect sleep quality. However, the relationship between cough burden and sleep disturbances in patients undergoing antifib...

(This article belongs to the Section Respiratory Medicine)
  • Article
  • Open Access
706 Views
11 Pages

Comparison Between Pipeline Embolization Device and Derivo Embolization Device for the Treatment of Unruptured Cerebral Aneurysms: A Single-Center Analysis

  • Weis Naziri,
  • Stefan Daniel Gheorghe,
  • Philipp Dietrich,
  • Michael Kettner,
  • Ruben Mühl-Benninghaus,
  • Umut Yilmaz,
  • Wolfgang Reith and
  • Andreas Simgen

Background: The introduction of flow diverters (FDs) has greatly enhanced the treatment of cerebral aneurysms. This study compares two FDs, the Pipeline Embolization Device (PED) and the Derivo Embolization Device (DED), in terms of technical, angiog...

(This article belongs to the Section Clinical Neurology)
  • Systematic Review
  • Open Access
1,049 Views
28 Pages

Intentional Insulin Omission (Diabulimia) in Patients with Insulin-Dependent Diabetes: An Eating Disorder? A Systematic Review

  • Maria Benedetta Anesini,
  • Mario Pinto,
  • Michela Bellezza,
  • Georgios D. Kotzalidis,
  • Tommaso Callovini,
  • Silvia Montanari,
  • Camilla Scialpi,
  • Gabriele Sani,
  • Lorenzo Moccia and
  • Delfina Janiri

Background/Objectives: Intentional insulin omission (IIO), commonly referred to as diabulimia, is a high-risk behavioural phenomenon observed mainly in adolescents and young adults with type 1 diabetes mellitus (T1D). Defined as the deliberate reduct...

(This article belongs to the Special Issue Mind–Body Connection: The Impact of Mental Health on Physical Well-Being)
  • Systematic Review
  • Open Access
1 Citations
772 Views
17 Pages

Tracheostomy During Extracorporeal Membrane Oxygenation in Adult ICU Patients: A Systematic Review

  • Giuseppe Neri,
  • Giuseppe Mazza,
  • Jessica Ielapi,
  • Helenia Mastrangelo,
  • Federico Longhini,
  • Vincenzo Bosco,
  • Alessandro Russo,
  • Francesca Serapide,
  • Corrado Pelaia and
  • Eugenio Garofalo
  • + 1 author

Background/Objectives: Extracorporeal membrane oxygenation (ECMO) is increasingly used in adult critical care, but tracheostomy during ECMO remains controversial because of bleeding risk, anticoagulation exposure, and variability in patient selection...

(This article belongs to the Section Intensive Care)
  • Technical Note
  • Open Access
619 Views
14 Pages

Exoscopic Extraforaminal Lumbar Interbody Fusion for Lumbar Degenerative Disease: Technical Considerations and Clinical Outcomes During the Early Learning Curve

  • Kentaro Yamane,
  • Shinichiro Takao,
  • Kanji Sasaki,
  • Wataru Narita,
  • Hisakazu Shitozawa,
  • Kazuhiro Takeuchi and
  • Shinnosuke Nakahara

Background/Objectives: Extraforaminal lumbar interbody fusion provides indirect decompression without entering the spinal canal, but its uptake has been limited by poor visualization and risk of exiting nerve root injury. We describe a minimally inva...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
599 Views
14 Pages

Background: A non-penal bicycle helmet mandate was implemented in the Republic of Korea on 28 September 2018, yet post-implementation epidemiologic evidence remains limited. This study evaluated changes in helmet wearing and injury outcomes before an...

(This article belongs to the Special Issue Clinical Updates in Trauma and Emergency Medicine)
  • Systematic Review
  • Open Access
552 Views
14 Pages

Feasibility and Safety of Endoscopic Peroral Cholangioscopy in Surgically Altered Anatomy: A Systematic Review and Meta-Analysis

  • Noemi Gualandi,
  • Pablo Cortegoso Valdivia,
  • Giuliano Francesco Bonura,
  • Tommaso Gabbani,
  • Paola Soriani and
  • Mauro Manno

Background/Objectives: Endoscopic retrograde cholangiopancreatography (ERCP) in patients with surgically altered anatomy (SAA) presents significant technical challenges due to altered bowel reconstructions. Endoscopic peroral cholangioscopy (POC) off...

(This article belongs to the Special Issue Advances in Diagnosis and Management of Pancreatobiliary Disorders—2nd Edition)
  • Article
  • Open Access
562 Views
19 Pages

Motor Outcomes of Robot-Assisted Versus Conventional Occupational Therapy for Upper-Limb Recovery in Subacute Stroke: A Retrospective Cohort Study with Exploratory Neurocognitive Outcomes

  • Eunju Na,
  • Sumin Lee,
  • Joon Won Seo,
  • Seung Ok Nam,
  • Eunyoung Kang,
  • Dong-Hyuk Kim,
  • Sunghoon Lee,
  • Soo-Hyun Soh,
  • Hyung-Ju Na and
  • Younkyung Cho

Background/Objectives: Robot-assisted therapy (RAT) can deliver repetitive, feedback-enriched upper-limb practice after stroke, but evidence comparing RAT with dose-matched conventional occupational therapy (COT) under routine inpatient conditions&md...

(This article belongs to the Special Issue Rehabilitation and Management of Stroke)
  • Review
  • Open Access
2,817 Views
19 Pages

Neuromuscular Blocking Agents in Anesthesia: A Narrative Review of Contemporary Challenges and Reversal Approaches

  • Paweł Radkowski,
  • Marta Jutrzenka,
  • Maciej Szewczyk,
  • Alicja Witkowska,
  • Marcin Muża,
  • Dariusz Onichimowski and
  • Łukasz Grabarczyk

Medical errors are inevitable and will happen to almost every specialist. In anesthesiology, one of the main concerns is the inappropriate application of muscle relaxants (MRs). As this group of drugs plays a significant role in facilitating endotrac...

(This article belongs to the Section Anesthesiology)
  • Article
  • Open Access
509 Views
13 Pages

Background: This study aimed to evaluate the image quality of non-contrast-enhanced whole-heart coronary MR angiography (CMRA) using three different sequences: coronal-plane balanced turbo field echo (BTFE) at 3T, axial-plane modified Dixon (mDixon)...

(This article belongs to the Special Issue Advanced Applications of Magnetic Resonance Imaging (MRI) in Clinical Diagnosis)
  • Article
  • Open Access
774 Views
11 Pages

A Novel Technique for Reconstruction of the Canthal Ligaments of the Lower Eyelid Using Barbed Sutures

  • Yutaro Araki,
  • Kazuki Shimada,
  • Miki Fujii,
  • Takako Komiya and
  • Hajime Matsumura

Background/Objectives: Lower eyelid malposition is a recognized complication following eyelid tumor excision, trauma, or degenerative changes, and is frequently associated with laxity or disruption of the canthal ligaments. Conventional reconstructio...

(This article belongs to the Special Issue Advances in Oculoplastic Surgery: From Eyelid Reconstruction to Innovative Techniques)

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J. Clin. Med. - ISSN 2077-0383