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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Headache: Updates on the Assessment, Diagnosis and Treatment

edited by

Ernesto Anarte-Lazo

and

Carlos Bernal-Utrera

submission deadline 25 Jun 2026 | 9 articles | Viewed by 23924 | Submission Open

Keywords: headache; migraine; tension-type headache; cervicogenic headache; therapeutic exercise

(This special issue belongs to the Section Clinical Neurology)

Oral Health and Dental Care: Current Advances and Future Options

edited by

Massimo Amato

Federica Di Spirito

and Alessia Bramanti

submission deadline 25 Jun 2026 | 8 articles | Viewed by 19665 | Submission Open

Keywords: oral health; dental care; technologies; innovation; dental materials

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Cataract and Refractive Surgery and Intraocular Lens Implantation: Clinical Advances and Perspectives

edited by Janusz Skrzypecki

submission deadline 25 Jun 2026 | 10 articles | Viewed by 14026 | Submission Open

Keywords: cataract surgery; intraocular lens power calculation; intraocular lenses; EDoF IOL; multifocal IOL; monofocal IOL; laser refractive surgery

(This special issue belongs to the Section Ophthalmology)

Innovations in Maxillofacial Surgery

edited by

Carlos Navarro-Cuéllar

José Luis Cebríán-Carretero

and Ignacio Navarro Cuéllar

submission deadline 25 Jun 2026 | 6 articles | Viewed by 13302 | Submission Open

Keywords: orthognathic surgery; sleep apnea; 3D technologies; regenerative medicine; reconstructive surgery; facial trauma; minimally invasive surgery; oncology

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Recent Research Progress in Pediatric Orthopedic Surgery

edited by

Catharina Chiari

and Madeleine Willegger

submission deadline 25 Jun 2026 | 6 articles | Viewed by 11969 | Submission Open

Keywords: pediatric orthopedics; deformity correction; pediatric hip; pediatric trauma; basic research in pediatric orthopedics; clubfoot; pediatric foot and ankle deformities; pediatric hand

(This special issue belongs to the Section Clinical Pediatrics)

Advancements in Emergency Medicine Practices and Protocols

edited by Vincenzo G. Menditto and Beatrice Gasperini

submission deadline 25 Jun 2026 | 8 articles | Viewed by 9064 | Submission Open

Keywords: emergency; pulmonary embolism; trauma; management; guidelines; frailty; emergency department observation unit

(This special issue belongs to the Section Emergency Medicine)

Exploring Artificial Intelligence in Precision Medicine for Gastrointestinal Diseases

edited by Vincenzo Davide Palumbo

submission deadline 25 Jun 2026 | 4 articles | Viewed by 8533 | Submission Open

Keywords: cholangiocarcinoma; biliary tree stenoses; colorectal cancer; endoscopic image analysis; IBD; gastrointestinal disorders

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Trends and Challenges in Critical Care Management

edited by

Anna Wrzosek

submission deadline 25 Jun 2026 | 4 articles | Viewed by 7948 | Submission Open

Keywords: critical care; intensive care; extracorporeal organ support; mechanical ventilation; personalized medicine; artificial intelligence; infections; antimicrobial resistance; COVID-19

(This special issue belongs to the Section Intensive Care)

Anesthesia and Intensive Care in Orthopedic and Trauma Surgery

edited by Liliana Mirea, Răzvan Ene and Cristian Cobilinschi

submission deadline 25 Jun 2026 | 2 articles | Viewed by 7528 | Submission Open

Keywords: opioid sparing analgetic technique; pain management; perioperative medicine; perioperative cognitive disfunction; delirium

(This special issue belongs to the Section Intensive Care)

Advances in Gastroenterology and Hepatology: Bridging Basic Science, Clinical Insights, and Translational Medicine

edited by

Abdulrahman Ismaiel

and

Ștefan Lucian Popa

submission deadline 25 Jun 2026 | 6 articles | Viewed by 7386 | Submission Open

Keywords: hepatology; gastroenterology; IBD; IBS; MASLD; liver cirrhosis; artificial intelligence; disorders of gut– brain interaction; cancer; gut microbiota; diagnosis; management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Targeted Treatment of Oral Cancer

edited by

Yasmine Ghantous

and

Claudia Malheiros Coutinho-Camillo

submission deadline 25 Jun 2026 | 3 articles | Viewed by 7093 | Submission Open

Keywords: precision medicine; immunotherapy; targeted drugs; combination therapy; tumor immune evasion; clinical trials

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Updates in Cardiac Electrophysiology: 2nd Edition

edited by Kenneth C. Bilchick

submission deadline 25 Jun 2026 | 2 articles | Viewed by 5357 | Submission Open

Keywords: arrhythmias; atrial fibrillation; cardiac electrophysiology; heart rhythm disorders; ablation; ventricular tachycardia; remote monitoring; digital health; artificial intelligence; cardiac magnetic resonance

(This special issue belongs to the Section Cardiology)

Innovations and Future Directions in Valvular Heart Disease: Imaging, Technology, and Translational Research

edited by

Mohammad Kassar

, Muhammed Gerçek and Felix Rudolph

submission deadline 25 Jun 2026 | 4 articles | Viewed by 4789 | Submission Open

Keywords: prosthetic heart valve; heart valve pathophysiology; structural heart valve interventions; echocardiographic assessment; cardiovascular imaging; valvular heart disease; valvular regurgitation; valvular stenosis; minimally invasive surgery; concomitant valve disease

(This special issue belongs to the Section Cardiology)

Pediatric Neurosurgery: Clinical Advances in Diagnostics and Perioperative Management

edited by Kara Leigh Krajewski and Ulrich-Wilhelm Thomale

submission deadline 25 Jun 2026 | 2 articles | Viewed by 4057 | Submission Open

Keywords: rapid sequence MRI; intraoperative MRI; perioperative management; neurocritical care; patient selection; M&M conferences; surgical team; rehabilitation

(This special issue belongs to the Section Clinical Pediatrics)

Psychological Pain and Suicidal Behavior: Clinical Implications

edited by Adrián Alacreu-Crespo

submission deadline 25 Jun 2026 | 4 articles | Viewed by 3796 | Submission Open

Keywords: suicidal behavior; psychological pain; pain tolerance; therapeutic interventions; clinical outcomes

(This special issue belongs to the Section Mental Health)

Advances and Innovations in Hand Surgery

edited by

David L. Colen

, Jason Wink and Anthony Archual

submission deadline 25 Jun 2026 | 2 articles | Viewed by 3639 | Submission Open

Keywords: hand surgery; peripheral nerve surgery; shared decision making; microsurgery; arthritis; compression neuropathy; carpal tunnel; cubital tunnel

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Current and Emerging Treatment Options in Colorectal Cancer

edited by Michael Osseis

submission deadline 25 Jun 2026 | 2 articles | Viewed by 2458 | Submission Open

Keywords: colorectal cancer (CRC); emerging treatment options; targeted therapies; new surgical technologies; precision medicine

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cystic Fibrosis: Management Strategies and Patient Outcomes

edited by Marta Rachel

submission deadline 25 Jun 2026 | 3 articles | Viewed by 2419 | Submission Open

Keywords: cystic fibrosis; multidisciplinary care; personalized medicine; patient outcomes; telemedicine; pediatric pulmonology; CFTR modulators; chronic disease management

(This special issue belongs to the Section Respiratory Medicine)

Oral Health and Systemic Diseases: Clinical Insights

edited by

Fabio Piras

submission deadline 25 Jun 2026 | 1 articles | Viewed by 1902 | Submission Open

Keywords: oral health; endodontics; orthodontic; periodontal disease; dental caries

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in Immunohematology: From Pathophysiology to Tailored Treatments

edited by

Giorgio Costagliola

submission deadline 25 Jun 2026 | 1 articles | Viewed by 1788 | Submission Open

Keywords: autoimmune cytopenia; hemophagocytic lymphohistiocytosis; inborn errors of immunity; lymphoproliferative diseases; malignancy; monoclonal antibodies; secondary immunodeficiency; vaccination

(This special issue belongs to the Section Immunology & Rheumatology)

Technological Advancements and Clinical Innovations in Diagnostic and Interventional Radiology: 2nd Edition

edited by

Massimo Venturini

and

Federico Fontana

submission deadline 25 Jun 2026 | 2 articles | Viewed by 1779 | Submission Open

Keywords: artificial intelligence; radiomics; image fusion; spectral computed tomography; functional magnetic resonance im-aging; CO2 angiography; balloon-occluded transcatheter arterial chemoembolization

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Advancing Neonatal Seizures and Epilepsy: New Perspectives and Interventions

edited by

Elena Pavlidis

and Gaetano Cantalupo

submission deadline 25 Jun 2026 | 1 articles | Viewed by 1720 | Submission Open

Keywords: neonatal seizures; neonatal epilepsy; neonatal EEG; automated EEG analysis; neonatal brain monitoring; genetic; precision medicine; genetic epilepsies; genome; exome

(This special issue belongs to the Section Clinical Pediatrics)

Current Concepts and Clinical Application of Echocardiography

edited by

Marco Solari

submission deadline 25 Jun 2026 | 2 articles | Viewed by 1256 | Submission Open

Keywords: echocardiography; clinical echocardiography; advanced echocardiography; cardiovascular disease; clinical cardiology

(This special issue belongs to the Section Cardiology)

Upper Airway Management in Obstructive Sleep Apnea: Latest Advances and Future Perspectives

edited by Shintaro Chiba

submission deadline 25 Jun 2026 | 1 articles | Viewed by 802 | Submission Open

Keywords: obstructive sleep apnea (OSA); sleep surgery; upper airway stimulation (UAS); upper airway physiology

(This special issue belongs to the Section Respiratory Medicine)

Coronary Artery Bypass Grafting: Contemporary Clinical Research Update

edited by

Arian Arjomandi Rad

submission deadline 25 Jun 2026 | 2 articles | Viewed by 757 | Submission Open

Keywords: coronary artery bypass grafting; arterial grafts; graft patency; hybrid coronary revascularization; perioperative management; outcomes research; risk stratification; frailty; minimally invasive/robotic CABG; antithrombotic therapy

(This special issue belongs to the Section Cardiology)

Advanced Image-Enhanced Endoscopy and Colonoscopy

edited by

Giuseppinella Melita

Marcello F. Maida

and Simona Di Caro

submission deadline 25 Jun 2026 | 1 articles | Viewed by 404 | Submission Open

Keywords: gastrointestinal endoscopy; colorectal cancer; endoscopic screening; artificial intelligence; chromoendoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Integrating Artificial Intelligence and Contextual Factors in Emergency Care

edited by Ancor Sanz-García and

José Luis Martín-Conty

submission deadline 25 Jun 2026 | 1 articles | Viewed by 393 | Submission Open

Keywords: emergency care; artificial intelligence; early warning systems; data-driven healthcare; predictive analytics

(This special issue belongs to the Section Emergency Medicine)

Clinical Advances of Aesthetic Plastic Surgery and Aesthetic Medicine

edited by Valentina Pinto and Rosalba Russo

submission deadline 25 Jun 2026 | Viewed by 379 | Submission Open

Keywords: aesthetic plastic surgery; aesthetic medicine; emerging technologies and devices in aesthetics; regenerative medicine and surgery; vulvovaginal surgery; complications in aesthetic medicine

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

IgA Nephropathy: Clinical Updates and Prospects

edited by

Meritxell Ibernon

submission deadline 25 Jun 2026 | Viewed by 345 | Submission Open

Keywords: pathogenesis of IgA nephropathy; novel therapies; role of complement system; risk factors for disease progression; proteomic approach; serologic biomarkers; histological classification

(This special issue belongs to the Section Nephrology & Urology)

Myocardial Infarction: Clinical Management and Future Options

edited by

Kenichi Sakakura

submission deadline 25 Jun 2026 | Viewed by 335 | Submission Open

Keywords: myocardial infarction; percutaneous coronary intervention; optimal medical therapy; clinical outcomes; cardiogenic shock; mechanical cardiac support device

(This special issue belongs to the Section Cardiology)

Diet and Nutritional Aspects in Cardiovascular-Kidney-Metabolic Diseases (CKM)

edited by Krishnaswami Vijayaraghavan

submission deadline 25 Jun 2026 | Viewed by 303 | Submission Open

Keywords: cardiovascular-kidney-metabolic diseases (CKM); obesity; diabetes and metabolic syndrome; dietary factors; nutritional aspects; food policy and food security; chronic kidney disease; heart disease; technology

(This special issue belongs to the Section Clinical Nutrition & Dietetics)

Advances in Minimally Invasive and Endoscopic Neurosurgery

edited by Shunsuke Shibao

submission deadline 25 Jun 2026 | Viewed by 279 | Submission Open

Keywords: minimally invasive; endoscopic; keyhole; endonasal; transorbital; skull base; complications; surgical outcomes; technical innovations; robotic neurosurgery

(This special issue belongs to the Section Clinical Neurology)

Human Immunodeficiency Virus: From Clinical Studies to Patient Outcomes

edited by Vítor Duque

submission deadline 25 Jun 2026 | Viewed by 243 | Submission Open

Keywords: HIV/AIDS; clinical trials; patient outcomes; clinical translational research

(This special issue belongs to the Section Infectious Diseases)

Cancer Prevention and Early Detection: Epidemiological Approaches and Public Health Strategies

edited by

Carmen Martos

and

Francesco Giusti

submission deadline 25 Jun 2026 | Viewed by 222 | Submission Open

Keywords: cancer prevention; cancer screening; risk factors; cancer treatment; health information systems; cancer registry; cancer inequalities

(This special issue belongs to the Section Epidemiology & Public Health)

Acute Kidney Injury: Latest Advances and Prospects

edited by

Emanuele de Simone

and Kianoush Kashani

submission deadline 26 Jun 2026 | 7 articles | Viewed by 9887 | Submission Open

Keywords: acute kidney injury (AKI); sepsis; septic shock; renal replacement therapy; intensive care; specialized interventions; biomarkers; risk factors; “ Green Practice” ; nephrology; epidemiology; multidisciplinary approach

(This special issue belongs to the Section Nephrology & Urology)

Multifactorial Causation and Therapies of Myopia: 2nd Edition

edited by

César Villa Collar

Cristina Alvarez-Peregrina

and

David Piñero

submission deadline 26 Jun 2026 | 1 articles | Viewed by 1935 | Submission Open

Keywords: epidemiology; genetics; premyopia; simple and pathological myopia; orthokeratology; lenses for myopia control; blue light and red light; binocular vision and ocular optics; artificial intelligence

(This special issue belongs to the Section Ophthalmology)

Advances in General and Regional Anaesthesia

edited by Michał Jan Stasiowski,

Nikola Zmarzły

and

Beniamin Oskar Grabarek

submission deadline 26 Jun 2026 | 1 articles | Viewed by 1325 | Submission Open

Keywords: general anaesthesia; regional anaesthesia; ropivacaine; bupivacaine; postoperative pain; postoperative nausea and vomiting; preventive analgesia; rescue opioid analgesia; total intravenous anaesthesia; inhalational anaesthesia

(This special issue belongs to the Section Anesthesiology)

Imaging and Molecular Biomarkers: The New Approach to Degenerative Retinal Diseases

edited by

Giulia Midena

and

Elisabetta Pilotto

submission deadline 28 Jun 2026 | 4 articles | Viewed by 4476 | Submission Open

Keywords: ophthalmology; degenerative retinal diseases; imaging biomarkers; multimodal imaging; OCT; OCT angiography; molecular biomarkers; precision medicine; translational ophthalmic research

(This special issue belongs to the Section Ophthalmology)

Advances in Gene Therapy for Retinal Diseases

edited by Tahreem Aman Mir

submission deadline 28 Jun 2026 | 1 articles | Viewed by 2416 | Submission Open

Keywords: gene therapy; inherited retinal degenerations; age-related macular degeneration; diabetic retinopathy

(This special issue belongs to the Section Ophthalmology)

Youth Sports Injuries: From Prevalence to Prevention

edited by Swarup Mukherjee and

Gregory C. Bogdanis

submission deadline 30 Jun 2026 | 4 articles | Viewed by 17488 | Submission Open

Keywords: youth sports injuries; musculoskeletal injuries; injury prevention; sport safety; youth athletes

(This special issue belongs to the Section Sports Medicine)

Pregnancy Complications and Maternal-Perinatal Outcomes

edited by

Angelo Sirico

submission deadline 30 Jun 2026 | 5 articles | Viewed by 6195 | Submission Open

Keywords: pregnancy; high-risk; GDM; preeclampsia; fetal growth restriction; diabetes; placenta; ultrasound

(This special issue belongs to the Section Obstetrics & Gynecology)

Children and Adolescent Mood Disorders: Risks and Treatment

edited by

Angelo Fraschetti

and

Emanuela Mari

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2971 | Submission Open

Keywords: emotional dysregulation; mood disorders; adolescence; anxiety; depression; addiction; psychotherapy; pharmacological treatments; prevention programs

(This special issue belongs to the Section Mental Health)

The Atrial Fibrillation–Heart Failure Interconnection: Challenges and Innovations in Diagnosis and Treatment

edited by

Roberto De Ponti

and

Michele Golino

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1634 | Submission Open

Keywords: atrial fibrillation; catheter ablation; ventricular dysfunction; myocardial remodeling; diastolic dysfunction; biomarkers; anti-arrhythmia agents; risk assessment; artificial intelligence; telemedicine

(This special issue belongs to the Section Cardiovascular Medicine)

Ergonomics and Low Back Pain: Integrative Approaches to Prevention, Assessment and Management

edited by

Janan Abbas

and

Deborah Alperovitch

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1565 | Submission Open

Keywords: advanced in diagnostic methods; therapeutic innovations; multidisciplinary and personalized care models; prevention and rehabilitation; non-pharmacological strategies; ergonomics; biomechanics

(This special issue belongs to the Section Orthopedics)

Advanced Technologies, Concepts, and Topics in Modern Neurosurgery

edited by

Samer Zawy Alsofy

and Ralf Stroop

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1232 | Submission Open

Keywords: modern neurosurgery; virtual reality; augmented reality; intraoperative imaging; neuronavigation; artificial intelligence; machine learning; robotic surgery; 3D printing; neurovascular interventions; neuro-oncology; skull base surgery; functional neurosurgery; spinal neurosurgery; surgical innovation; image-guided surgery; personalized neurosurgical planning

(This special issue belongs to the Section General Surgery)

New Clinical Insights into Acute Respiratory Failure

edited by

Christophe Guervilly

submission deadline 30 Jun 2026 | 1 articles | Viewed by 991 | Submission Open

Keywords: acute respiratory failure; pathophysiology; advances respiratory monitoring; respiratory support strategies; respiratory mechanics; mechanical ventilation; respiratory drive; patient-ventilator asynchrony

(This special issue belongs to the Section Intensive Care)

Metastatic Colorectal Cancer Beyond Second-Line Treatment

edited by Jacopo Giuliani

submission deadline 30 Jun 2026 | 1 articles | Viewed by 983 | Submission Open

Keywords: metastatic colorectal cancer; subsequent lines; chemotherapy; targeted agents; radiotherapy; local therapy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

The Interplay of Trauma Symptoms and Cognitive Functioning: Clinical Implications

edited by

Jonathan Guez

and

Rotem Saar

submission deadline 30 Jun 2026 | Viewed by 314 | Submission Open

Keywords: trauma; stress; cognitive dysfunction; clinical syndromes; clinical implications

(This special issue belongs to the Section Mental Health)

Robotic-Assisted Hepato-Pancreato-Biliary (HPB) Surgery: Advances and Clinical Perspectives

edited by

Michele Tedeschi

and Riccardo Memeo

submission deadline 30 Jun 2026 | Viewed by 300 | Submission Open

Keywords: liver surgery; pancreatic surgery; HPB surgery; robotic surgery; robotic systems; advances in HPB surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Integrating a One Health Approach into Antimicrobial Stewardship and Shared Care in Wound Management

edited by Joanna F. Blackburn

submission deadline 30 Jun 2026 | Viewed by 234 | Submission Open

Keywords: antimicrobial stewardship; antimicrobial resistance; one health; shared care; wound care; wound care management; chronic wound care; acute wound care; digital health; wound diagnostics; antimicrobials; antibiotics

(This special issue belongs to the Section Dermatology)

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