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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovations in Preeclampsia
edited by Jeffrey M. Denney and
submission deadline 22 Dec 2025 | 4 articles | Viewed by 16858
Keywords: preeclampsia; pathophysiology; renin; SFlt-1; PlGF; hypertensive disorders of pregnancy; imitators of preeclampsia; vascular reactivity
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Advances of Adolescent Idiopathic Scoliosis: Current Status and Prospects
edited by Maria Chiara Maccarone and
submission deadline 22 Dec 2025 | 2 articles | Viewed by 4077
Keywords: adolescent idiopathic scoliosis; treatment; non-invasive therapies; surgery; neurophisiology; imaging; motion analysis; personalized medicine
(This special issue belongs to the Section Orthopedics)
Innovative Aspects in Dental Implantology and Related Clinical Research (Second Edition) submission deadline 22 Dec 2025 | 1 articles | Viewed by 796
Keywords: dental implants; implantology; bone regeneration; implant-supported prosthesis; zygomatic implants; reconstructive surgery; pre-implant surgery; short implants
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
New Advances in Stereotactic Radiosurgery
edited by Shafak S. Aluwini
submission deadline 24 Dec 2025 | 2 articles | Viewed by 1223 | Submission Open
Keywords: stereotactic radiosurgery; clinical outcomes; brachytherapy; IMRT; brain metastases; arteriovenous malformations; functional disorders; radiosurgery
(This special issue belongs to the Section Oncology)
Sports Injury: Clinical Prevention and Treatment
edited by , Susana Pulgar and
submission deadline 25 Dec 2025 | 4 articles | Viewed by 26344 | Submission Open
Keywords: injury prevention; team sports; talent identification; biobanding; injury burden; muscle injury; PHV
(This special issue belongs to the Section Sports Medicine)
Skin Diseases: From Diagnosis to Treatment
edited by
submission deadline 25 Dec 2025 | 6 articles | Viewed by 20195 | Submission Open
Keywords: skin; melanoma; NMSC; CTCL; mesenchymal
(This special issue belongs to the Section Dermatology)
Pathogenesis, Diagnosis, and Management of Upper Gastrointestinal Disease
edited by
submission deadline 25 Dec 2025 | 6 articles | Viewed by 14748 | Submission Open
Keywords: esophagus; stomach; duodenum; DGBI; FGIDs; Helicobacter; eosinophilic esophagitis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Technological Advances, Innovative Applications, and New Clinical Benefits of Computed Tomography submission deadline 25 Dec 2025 | 3 articles | Viewed by 12388 | Submission Open
Keywords: computed tomography (CT); spectral CT; dual-energy CT; dual-source spectral CT; dual-layer spectral CT; pho-ton-counting CT; photon-counting detector CT; spectral photon-counting CT; artificial intelligence; radiomics
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Targeted Treatment of Kidney Stones
edited by Carmen Gonzalez-Enguita and
submission deadline 25 Dec 2025 | 4 articles | Viewed by 11457 | Submission Open
Keywords: shockwave lithotripsy; ureteroscopy; percutaneous nephrolithotomy; laser lithotripsy; minimally invasive techniques; stone recurrence prevention
(This special issue belongs to the Section Nephrology & Urology)
Thyroid Cancer: Clinical Diagnosis and Treatment
edited by Alfred A. Simental
submission deadline 25 Dec 2025 | 5 articles | Viewed by 11308 | Submission Open
Keywords: thyroid nodule; thyroid ultrasound; radiofrequency ablation; molecular analysis; thyroid surgery
(This special issue belongs to the Section Oncology)
Clinical Epidemiology in Chronic Kidney Disease
edited by and Claudia Torino
submission deadline 25 Dec 2025 | 7 articles | Viewed by 10881 | Submission Open
Keywords: chronic kidney disease; end-stage kidney disease; dialysis; hypertension; renal disease; clinical nephrology; chronic renal failure
(This special issue belongs to the Section Nephrology & Urology)
New Clinical Advances in Sudden Cardiac Arrest and Ventricular Arrhythmias
edited by
submission deadline 25 Dec 2025 | 5 articles | Viewed by 10243 | Submission Open
Keywords: cardiac arrest; defibrillation; ventricular tachycardia; ventricular fibrillation; catheter ablation; non-invasive ablation; neuromodulation; stellate ganglion block
(This special issue belongs to the Section Cardiology)
Anterior Cruciate Ligament (ACL): Innovations in Clinical Management
edited by Xaver Feichtinger, and Georg Brandl
submission deadline 25 Dec 2025 | 5 articles | Viewed by 9561 | Submission Open
Keywords: ACL; graft choice; ACL repair; ALL; tibial slope
(This special issue belongs to the Section Orthopedics)
Recent Advances in Inflammatory and Infectious Skin Diseases (Second Edition)
edited by , Astrid Herzum and Paolo Romita
submission deadline 25 Dec 2025 | 4 articles | Viewed by 8536 | Submission Open
Keywords: atopic dermatitis; eczematous diseases; inflammatory skin diseases; chronic skin diseases; human herpesvirus; roseola syphilitica; psoriasis
(This special issue belongs to the Section Dermatology)
Pulmonary Embolism: Clinical Advances and Future Opportunities
edited by James Horowitz
submission deadline 25 Dec 2025 | 4 articles | Viewed by 6153 | Submission Open
Keywords: pulmonary embolism; risk stratification; pulmonary embolism response teams; high risk PE; massive PE; intermediate risk PE; sub massive PE; catheter directed thrombolysis; catheter thrombectomy; catheter directed embolectomy; extra corporeal membrane oxygenation
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Radiation Therapy for Cancers submission deadline 25 Dec 2025 | 3 articles | Viewed by 4278 | Submission Open
Keywords: radiation oncology; radiotherapy; cancer radiotherapy; cancer radiation therapy; radiobiology; predictive and prognostic biomarkers; cancer treatment; heavy ions radiation oncology; protontherapy; cancer biolology
(This special issue belongs to the Section Nuclear Medicine & Radiology)
New Insights in Skin Tumors: From Pathogenesis to Therapy
edited by Loredana Ungureanu and Simona C. Şenilǎ
submission deadline 25 Dec 2025 | 3 articles | Viewed by 2973 | Submission Open
Keywords: skin tumors; pathogenesis; diagnosis; personalized medicine; therapeutic strategies; dermato-oncology
(This special issue belongs to the Section Dermatology)
Innovations and Future Directions in Valvular Heart Disease: Imaging, Technology, and Translational Research
edited by , Muhammed Gerçek and Felix Rudolph
submission deadline 25 Dec 2025 | 3 articles | Viewed by 1615 | Submission Open
Keywords: prosthetic heart valve; heart valve pathophysiology; structural heart valve interventions; echocardiographic assessment; cardiovascular imaging; valvular heart disease; valvular regurgitation; valvular stenosis; minimally invasive surgery; concomitant valve disease
(This special issue belongs to the Section Cardiology)
Psychological Pain and Suicidal Behavior: Clinical Implications
edited by Adrián Alacreu-Crespo
submission deadline 25 Dec 2025 | 2 articles | Viewed by 789 | Submission Open
Keywords: suicidal behavior; psychological pain; pain tolerance; therapeutic interventions; clinical outcomes
(This special issue belongs to the Section Mental Health)
Cardiac Imaging Techniques in Heart Failure Care
edited by David Snipelisky
submission deadline 25 Dec 2025 | Viewed by 339 | Submission Open
Keywords: heart failure; advanced imaging; cardiac imaging; echocardiography; cardiomyopathies
(This special issue belongs to the Section Cardiology)
Kidney Health Under Microscope
edited by
submission deadline 25 Dec 2025 | Viewed by 314 | Submission Open
Keywords: complications; IgA nephropathy; glomerulonephritis; atypical haemolytic uraemic syndrome; systemic vasculitis; lupus nephritis; mineral bone disease; anaemia; xenotransplantation; nephrolithiasis
(This special issue belongs to the Section Nephrology & Urology)
Cardiac Rehabilitation: Clinical Challenges and New Insights
edited by Melissa Tracy
submission deadline 26 Dec 2025 | 3 articles | Viewed by 10744 | Submission Open
Keywords: cardiovascular disease; cardiac rehabilitation; atrial fibrillation
(This special issue belongs to the Section Cardiology)
Current Clinical Treatments and Challenges for Cardiovascular Diseases
edited by Georgios Bouras and
submission deadline 26 Dec 2025 | 4 articles | Viewed by 7743 | Submission Open
Keywords: heart failure; coronary artery disease; atrial fibrillation; cardiomyopathies; hypertension
(This special issue belongs to the Section Cardiovascular Medicine)
New Advances in Extracorporeal Life Support (ECLS)
edited by Robertas Stasys Samalavičius, and
submission deadline 26 Dec 2025 | 2 articles | Viewed by 5551 | Submission Open
Keywords: extracorporeal life support (ECLS); extracorporeal membrane oxygenation (ECMO); innovations in ECLS; respiratory failure; cardiogenic shock; eCPR
(This special issue belongs to the Section Emergency Medicine)
Current Clinical Advances and Challenges for Endourology submission deadline 26 Dec 2025 | 2 articles | Viewed by 2059 | Submission Open
Keywords: urolithiasis; upper tract urothelial carcinoma; benign prostatic hyperplasia; minimally invasive surgical therapies
(This special issue belongs to the Section Nephrology & Urology)
Multifactorial Causation and Therapies of Myopia: 2nd Edition submission deadline 26 Dec 2025 | 1 articles | Viewed by 1121 | Submission Open
Keywords: epidemiology; genetics; premyopia; simple and pathological myopia; orthokeratology; lenses for myopia control; blue light and red light; binocular vision and ocular optics; artificial intelligence
(This special issue belongs to the Section Ophthalmology)
Clinical Updates on Metabolic and Bariatric Surgery
edited by Maria-Jose Barahona
submission deadline 27 Dec 2025 | 1 articles | Viewed by 1465 | Submission Open
Keywords: obesity; bariatric surgery; metabolic surgery; weight loss; obesity treatment; metabolic disorders
(This special issue belongs to the Section General Surgery)
Atrial Fibrillation Rhythm Management: Outcomes, Innovations, and Future Directions
edited by Roberto Scacciavillani and Gemma Pelargonio
submission deadline 28 Dec 2025 | 6 articles | Viewed by 6316 | Submission Open
Keywords: atrial fibrillation; catheter ablation; radiofrequency; cryoablation; pulsed field ablation; cardioneuroablation; left bundle branch area pacing
(This special issue belongs to the Section Cardiology)
Lung Transplantation: Current Strategies and Future Directions
edited by Omer Senbaklavaci and György Lang
submission deadline 28 Dec 2025 | 1 articles | Viewed by 1773 | Submission Open
Keywords: lung transplantation; graft optimization; immunosuppression; artificial lung; xenotransplantation; end-stage lung disease; donor lung preservation; chronic lung allograft dysfunction
(This special issue belongs to the Section Respiratory Medicine)
Imaging and Molecular Biomarkers: The New Approach to Degenerative Retinal Diseases submission deadline 28 Dec 2025 | 2 articles | Viewed by 1156 | Submission Open
Keywords: ophthalmology; degenerative retinal diseases; imaging biomarkers; multimodal imaging; OCT; OCT angiography; molecular biomarkers; precision medicine; translational ophthalmic research
(This special issue belongs to the Section Ophthalmology)
Managements of Venous Thromboembolism submission deadline 29 Dec 2025 | 4 articles | Viewed by 2982 | Submission Open
Keywords: venous thromboembolism; deep vein thrombosis; pulmonary embolism; anticoagulation therapy; direct oral anticoagulants; risk stratification; bleeding risk; artificial intelligence; personalized medicine
(This special issue belongs to the Section Vascular Medicine)
Pediatric Neurosurgery: Clinical Advances in Diagnostics and Perioperative Management
edited by Kara Leigh Krajewski and Ulrich-Wilhelm Thomale
submission deadline 29 Dec 2025 | 1 articles | Viewed by 1733 | Submission Open
Keywords: rapid sequence MRI; intraoperative MRI; perioperative management; neurocritical care; patient selection; M&M conferences; surgical team; rehabilitation
(This special issue belongs to the Section Clinical Pediatrics)
Current Concepts and Clinical Application of Echocardiography
edited by
submission deadline 29 Dec 2025 | Viewed by 177 | Submission Open
Keywords: echocardiography; clinical echocardiography; advanced echocardiography; cardiovascular disease; clinical cardiology
(This special issue belongs to the Section Cardiology)
Treatment of Atopic Dermatitis
edited by and Ricardo Ruíz-Villaverde
submission deadline 30 Dec 2025 | 7 articles | Viewed by 23103 | Submission Open
Keywords: atopic dermatitis; eczema; topical treatment; systemic treatment; biological therapy; JAK inhibitor; antipruritic treatment
(This special issue belongs to the Section Dermatology)
Chronic Pain: Non-Pharmacological Treatments and Rehabilitation Strategies
edited by Matteo Ponzano
submission deadline 30 Dec 2025 | 8 articles | Viewed by 19713 | Submission Open
Keywords: pain; neuropathies; musculoskeletal health; biopsychosocial management; physical therapy; cognitive behavioral therapies
(This special issue belongs to the Section Clinical Rehabilitation)
Current Challenges in Inflammatory Bowel Diseases submission deadline 30 Dec 2025 | 4 articles | Viewed by 10028 | Submission Open
Keywords: ulcerative colitis; Chron’ s disease; inflammatory bowel disease; colitis-associated cancer; novel pharmaceutics
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The State of Breast Reconstruction: From Surgical Methods to Patient-Reported Outcomes
edited by Geoffroy C. Sisk
submission deadline 30 Dec 2025 | 2 articles | Viewed by 6729 | Submission Open
Keywords: breast reconstruction; implant based; autologous tissue; oncoplastic; breast cancer reconstruction; patient-reported outcomes; acellular dermal matrix; prepectoral; lymphedema; microsurgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Recent Advances in Glaucoma Management
edited by Bogomil Voykov
submission deadline 30 Dec 2025 | 3 articles | Viewed by 5086 | Submission Open
Keywords: glaucoma; MIGS; microinvasive glaucoma surgery; quality of life; sustained-release drugs; wound healing modula-tion; intraocular pressure; intraocular pressure-lowering medication; microstent-supported bleb surgery; MIBS; neuroprotection
(This special issue belongs to the Section Ophthalmology)
Augmented and Artificial Intelligence in Ophthalmology
edited by Tina Felfeli, Edsel B. Ing, David Jose Mathew and Michael Balas
submission deadline 30 Dec 2025 | 2 articles | Viewed by 2928 | Submission Open
Keywords: artificial intelligence; ophthalmology; eye health; vision; teleophthalmology
(This special issue belongs to the Section Ophthalmology)
Inflammatory Bowel Disease: From Diagnosis to Treatment—2nd Edition
edited by Laura Maria Minordi and Daniela Pugliese
submission deadline 30 Dec 2025 | 3 articles | Viewed by 2661 | Submission Open
Keywords: Crohn’ s disease; ulcerative colitis; imaging; endoscopy; complications; advanced therapies; surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Shoulder Arthroplasty: Clinical Advances and Future Perspectives
edited by Vani J. Sabesan
submission deadline 30 Dec 2025 | 2 articles | Viewed by 1778 | Submission Open
Keywords: shoulder arthroplasty; reverse shoulder arthroplasty; perioperative optimization; multimodal pain management; rehabilitation protocols; outpatient shoulder arthroplasty; implant longevity; complication management; disparities in outcomes
(This special issue belongs to the Section Orthopedics)
Autoimmune Diseases and Multisystem Inflammation: Pathophysiology and Therapeutic Strategies
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 1482 | Submission Open
Keywords: autoimmune diseases; cardiovascular diseases; cutaneous diseases; gastrointestinal diseases; pulmonary diseases; renal diseases; systemic manifestation; rheumatoid arthritis; systemic lupus erythematosus; vasculitis
(This special issue belongs to the Section Immunology & Rheumatology)
State of the Art in Management of Aortic Aneurysm in Vascular Surgery
edited by Rana O. Afifi and Eanas Yassa
submission deadline 30 Dec 2025 | 3 articles | Viewed by 1361 | Submission Open
Keywords: aortic dissection; complex aortic surgery; endovascular aortic repair; aortic imaging; aortic aneurysm
(This special issue belongs to the Section Vascular Medicine)
Innovations and Challenges in Cardiovascular Surgery
edited by Marc Leon
submission deadline 30 Dec 2025 | 1 articles | Viewed by 1021 | Submission Open
Keywords: cardiovascular surgery; minimally invasive surgery; robotic surgery; hybrid; 3D printing; artificial intelligence; mechanical circulatory support; heart transplantation; valve disease; aortic dissection; ischemic heart disease; heart failure
(This special issue belongs to the Section Cardiovascular Medicine)
Current and Emerging Treatment Options in Colorectal Cancer
edited by Michael Osseis
submission deadline 30 Dec 2025 | 1 articles | Viewed by 356 | Submission Open
Keywords: colorectal cancer (CRC); emerging treatment options; targeted therapies; new surgical technologies; precision medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Interventional Cardiology: Recent Developments and Future Challenges
edited by and George Kassimis
submission deadline 30 Dec 2025 | Viewed by 298 | Submission Open
Keywords: percutaneous coronary intervention (PCI); drug-eluting stents (DES); high risk percutaneous coronary intervention (CHIP); chronic total occlusions (CTO); intravascular imaging (IVUS; OCT); coronary physiology (FFR; iFR); antiplatelet therapy; complex coronary interventions; mechanical circulatory support (MCS)
(This special issue belongs to the Section Cardiology)
Clinical Advances in Antiphospholipid Syndrome (APS)
edited by
submission deadline 30 Dec 2025 | Viewed by 213 | Submission Open
Keywords: thrombosis; pregnancy; antiphospholipid syndrome; lupus anticoagulant; antiphospholipid antibodies
(This special issue belongs to the Section Immunology & Rheumatology)
Plastic and Reconstructive Surgery of the Face: Chances and Challenges
edited by and Bogdan Andrei Suciu
submission deadline 30 Dec 2025 | Viewed by 208 | Submission Open
Keywords: facial plastic surgery; facial reconstruction procedures; tissue regeneration; esthetic facial procedures; digital imaging and customization; biomaterials in reconstructive surgery; flap surgery innovations; microsurgical precision techniques
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
New Developments in Hematopoietic Stem Cell Transplantation in Clinical Practice
edited by Mattia Algeri
submission deadline 30 Dec 2025 | Viewed by 191 | Submission Open
Keywords: hematopoietic stem cell transplantation; graft-versus-host disease (GVHD); conditioning regimens; immune reconstitution; donor selection; post-transplant complications; long-term survivorship
(This special issue belongs to the Section Hematology)
Challenges and Opportunities in Colorectal Cancer
edited by
submission deadline 30 Dec 2025 | Viewed by 139 | Submission Open
Keywords: colorectal cancer; screening; staging; treatment of colorectal cancer (CRC); high-risk patients; fecal occult testing; colonoscopy; lynch syndrome
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
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