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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Innovation in Endoscopic Sinus and Anterior Skull Base Surgery submission deadline 27 Nov 2025 | 1 articles | Viewed by 176 | Submission Open
Keywords: rhinology; endoscopic anterior skull base surgery; anterior skull base surgery; endoscopic sinus surgery; chronic rhinosinusitis (CRS); otolaryngology
(This special issue belongs to the Section Otolaryngology)
Management of Complex Infective Endocarditis
edited by Shekhar Saha, Tulio Caldonazo and Mateo Marin-Cuartas
submission deadline 27 Nov 2025 | Viewed by 114 | Submission Open
Keywords: infective endocarditis; imaging; diagnosis; cardiac surgery; pathogens; antibiotic treatment; risk estimation
(This special issue belongs to the Section Cardiology)
Advances in the Diagnosis and Management of Age-Related Macular Degeneration: 2nd Edition
edited by Tsutomu Yasukawa
submission deadline 28 Nov 2025 | 10 articles | Viewed by 11585 | Submission Open
Keywords: age-related macular degeneration; angiography; antivascular endothelial growth factor therapy; choroidal neovascularization; geographic atrophy; multimodal imaging; ophthalmology; optical coherence tomography; photodynamic therapy; retinal pigment epithelium
(This special issue belongs to the Section Ophthalmology)
New Trends in Mechanical Ventilation
edited by
submission deadline 28 Nov 2025 | 2 articles | Viewed by 7441 | Submission Open
Keywords: positive pressure ventilation; negative pressure ventilation; constant flow ventilation; PEEP; lung recruitment; obesity; laparoscopy; ARDS; atelectasis; total lung compliance
(This special issue belongs to the Section Anesthesiology)
Current Practices in Cardiovascular Perfusion and Recovery
edited by
submission deadline 28 Nov 2025 | 1 articles | Viewed by 2841 | Submission Open
Keywords: organ perfusion; ex vivo perfusion; ischemia– reperfusion injury; organ recovery; transplantation; machine perfusion; organ preservation
(This special issue belongs to the Section Cardiology)
Clinical Updates in Heart Transplantation
edited by
submission deadline 28 Nov 2025 | 2 articles | Viewed by 1558 | Submission Open
Keywords: heart transplantation; ex vivo heart preservation; immunosuppression; xenotransplantation; pre-clinical models; dilated cardiomyopathy; amyloidosis; congenital heart disease
(This special issue belongs to the Section Cardiology)
Innovations in Thoracic Surgery and Disease Management: Integrating Genomics, Technology, and Multidisciplinary Care submission deadline 28 Nov 2025 | Viewed by 247 | Submission Open
Keywords: thoracic surgery; thoracic disease; genomic medicine; artificial intelligence; advanced imaging; multidisciplinary care; minimally invasive surgery; robotic surgery; precision medicine
(This special issue belongs to the Section Respiratory Medicine)
State of the Art in Hepato-Pancreato-Biliary (HPB) Surgery
edited by and Konstantinos Bramis
submission deadline 28 Nov 2025 | 1 articles | Viewed by 178 | Submission Open
Keywords: hepato-pancreato-biliary (HPB) surgery; robotic surgery; laparoscopic surgery; liver resection; liver transplantation; pancreatectomy; liver thermoablation; extrahepatic cholangiocarcinoma; benign biliary disease; pancreatic neuroendocrine tumors; non-colorectal/non-neuroendocrine oligometastatic liver disease
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Novel Diagnostic and Therapeutic Opportunities in Inflammatory and Oncological Diseases in the Gastrointestinal Tract
edited by and Hubert Zatorski
submission deadline 28 Nov 2025 | Viewed by 131 | Submission Open
Keywords: cancer; inflammation; diagnosis; treatment; microbiota; gastrointestinal tract; gastroenterology; immunology
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Challenges in Maternal-Fetal Medicine
edited by Marzena Laskowska
submission deadline 29 Nov 2025 | 7 articles | Viewed by 17015 | Submission Open
Keywords: thrombocytopenia in pregnancy; multiple pregnancies; placental abruption; DIC; sepsis; chorioamnionitis; cholestasis; postpartum hemorrhage; emergency cervical cerclage; problems in pregnancy and labor; pregnancy complications; spina bifida; fetal well-being evaluation
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Advances in Critical Care Medicine
edited by Pietro Caironi
submission deadline 30 Nov 2025 | 14 articles | Viewed by 49502 | Submission Open
Keywords: critical care; artificial intelligence; extra-corporeal life support; mechanical ventilation; sepsis; infection; airway management; acute kidney injury; biomarkers; trauma
(This special issue belongs to the Section Intensive Care)
Recent Advances in Reconstructive Urology and Prosthetic Surgery
edited by Francisco E. Martins, Maurice Garcia and Jay Simhan
submission deadline 30 Nov 2025 | 5 articles | Viewed by 15629 | Submission Open
Keywords: male and female urogenital reconstruction; urologic trauma; urologic prosthetics; erectile dysfunction; urinary incontinence; artificial urinary sphincter; gender-affirming surgery; transgender; phalloplasty; vaginoplasty
(This special issue belongs to the Section Nephrology & Urology)
What’s New in Cardiomyopathies: Diagnosis, Treatment and Management
edited by
submission deadline 30 Nov 2025 | 6 articles | Viewed by 15093 | Submission Open
Keywords: cardiomyopathies; multimodality imaging; cardiac magnetic resonance; genetic testing; cardiogenetics; genetic cardiovascular disease; rare cardiovascular diseases
(This special issue belongs to the Section Cardiology)
Advancements in Cornea Transplantation
edited by Giulia Coco and Davide Romano
submission deadline 30 Nov 2025 | 8 articles | Viewed by 11789 | Submission Open
Keywords: corneal transplant; keratoplasty; DMEK; DSAEK; PK; cornea
(This special issue belongs to the Section Ophthalmology)
Personalized Risk Stratification with Diagnostic and Prognostic Relevance for Coronary Artery Disease: New Challenges and Opportunities in a New Era submission deadline 30 Nov 2025 | 5 articles | Viewed by 9487 | Submission Open
Keywords: coronary artery disease; cardiovascular prevention; risk stratification; cardiovascular pathology
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advances in Therapy of Trauma and Surgical Critical Care
edited by Rabail Chaudhry and George W. Williams
submission deadline 30 Nov 2025 | 2 articles | Viewed by 8069 | Submission Open
Keywords: regional anesthesia; critical care; trauma resuscitation; transfusion strategies; thermal injury; obstetric critical care; epitheliopathy; metabolomics; ICU pain management; trauma care subpopulations
(This special issue belongs to the Section Intensive Care)
Recent Progress in Rehabilitation Medicine—3rd Edition
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 7828 | Submission Open
Keywords: neuro-rehabilitation; cognitive rehabilitation; spinal rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; cancer rehabilitation; visceral rehabilitation; cardiac rehabilitation; pulmonary rehabilitation; renal rehabilitation; hepatic rehabilitation; rehabilitation for transplantation; fitness; peak VO2; multimorbidity and multiple disabilities (MMD); adding life to years and years to life
(This special issue belongs to the Section Clinical Rehabilitation)
Ischemic Stroke: Diagnosis and Treatment submission deadline 30 Nov 2025 | 4 articles | Viewed by 7340 | Submission Open
Keywords: stroke; reperfusion therapies; neuroimaging; brain ischemia; intracerebral hemorrhage; intravenous thrombolysis; mechanical thrombectomy
(This special issue belongs to the Section Clinical Neurology)
New Insights into Cardiovascular and Minimally Invasive Cardiac Surgery
edited by Parwis Massoudy and Hilmar C. Dörge
submission deadline 30 Nov 2025 | 4 articles | Viewed by 7281 | Submission Open
Keywords: coronary artery bypass grafting; aortic valve surgery; mitral valve surgery; aortic surgery; minimally invasive cardiac surgery
(This special issue belongs to the Section Cardiology)
Cardiac Arrhythmias: Recent Advances in Underlying Mechanisms, Diagnostic Options and Therapeutic Approaches
edited by Elisabeth M.J.P. Mouws and
submission deadline 30 Nov 2025 | 5 articles | Viewed by 6666 | Submission Open
Keywords: cardiac arrhythmia; atrial fibrillation; congenital heart disease; underlying mechanisms; therapeutic options
(This special issue belongs to the Section Cardiology)
Advances in the Diagnosis and Treatment of Ocular Surface Tumors and Diseases
edited by Sotiria Palioura, Carolina L. Mercado and
submission deadline 30 Nov 2025 | 2 articles | Viewed by 5422 | Submission Open
Keywords: ocular surface diseases; anterior segment imaging; chemotherapeutics; immunomodulatory agents; minimally invasive surgical techniques
(This special issue belongs to the Section Ophthalmology)
Clinical Research and Personalized Medicine in Inflammatory Bowel Disease
edited by and Loris Riccardo Lopetuso
submission deadline 30 Nov 2025 | 4 articles | Viewed by 4278 | Submission Open
Keywords: inflammatory bowel disease (IBD); personalized medicine; precision medicine; Crohn’ s disease; ulcerative colitis; targeted therapy; artificial intelligence
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Integrated Clinical Approaches to Managing Multimorbidity and Multiple Disabilities: Advances in Rehabilitation and Therapeutic Strategies
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3631 | Submission Open
Keywords: heart; lung; kidney; liver; bone; brain
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Advances of Breast Surgery and Reconstruction
edited by and Emanuele Cigna
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2038 | Submission Open
Keywords: breast reconstruction; autologous breast reconstruction; implant-based breast reconstruction; DIEP; LICAP; breast implant infection
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Novel Aspects of Endocrine Care: From Patient-Centred Management of Endocrine Diseases to Guidelines Standards submission deadline 30 Nov 2025 | 2 articles | Viewed by 1932 | Submission Open
Keywords: endocrine tumour; hormone; biomarker; neuroendocrine tumour; thyroidectomy; parathyroidectomy; bone; ad-renal gland; osteoporosis; pituitary gland; autoimmune; antibody; clinical study; computed tomography
(This special issue belongs to the Section Endocrinology & Metabolism)
Novel Developments on Diagnosis and Treatment of Gastrointestinal Cancer
edited by Bhaumik Patel
submission deadline 30 Nov 2025 | 2 articles | Viewed by 1677 | Submission Open
Keywords: colorectal cancer; gastric cancer; biomarker; novel therapy; immune microenvironment; gut microbiota; molecular mechanisms
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Orthodontics: State of the Art and Prospects
edited by Beatriz Tarazona-Álvarez and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1537 | Submission Open
Keywords: digital orthodontics; clear aligners; 3D printing; accelerated orthodontics; digital treatment plan; nanotechnology
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Thoracic Surgery Between Tradition and Innovations
edited by Jacopo Vannucci
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1359 | Submission Open
Keywords: thoracic surgery; lung cancer; pulmonary resections; pleural disease; perioperative medicine; mesothelioma; lung transplantation; chest wall resection and reconstruction; esophageal cancer; thoracic trauma; emergency; pulmonary metastasectomy
(This special issue belongs to the Section General Surgery)
Multiparametric Ultrasound Techniques for Liver Disease Assessments
edited by Francesco Giangregorio
submission deadline 30 Nov 2025 | 2 articles | Viewed by 1274 | Submission Open
Keywords: ultrasound; multiparametric ultrasound; hepatic ultrasound; contrast-enhanced ultrasound; contrast agents; diffuse hepatic diseases; focal liver lesions; hepatic elastography; liver stiffness; hepatic endosonography; hepatic EUS
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Orthopedic Surgery: Latest Advances and Perspectives
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1126 | Submission Open
Keywords: motion preservation; pain management; robotics/computer navigation; degenerative disc disease; orthobiologics; arthroplasty; trauma
(This special issue belongs to the Section Orthopedics)
Current Challenges in Orthopedic Trauma Surgery
edited by Pietro Maniscalco and Fabrizio Quattrini
submission deadline 30 Nov 2025 | 2 articles | Viewed by 1102 | Submission Open
Keywords: hip replacement; knee replacement; shoulder replacement; ankle replacement; trauma surgery; femur; future chal-lenges; surgical innovations
(This special issue belongs to the Section Orthopedics)
Challenges and Opportunities in Application of Laparoscopic, Robotic and Other Technological Advances in Gastrointestinal Surgery
edited by and Fabrizio Panaro
submission deadline 30 Nov 2025 | 1 articles | Viewed by 964 | Submission Open
Keywords: robotic surgery; laparoscopic surgery; artificial intelligence; technological advances
(This special issue belongs to the Section General Surgery)
Spine Surgery Innovations: Clinically Advanced Treatment and Technologies
edited by Jang W. Yoon
submission deadline 30 Nov 2025 | 1 articles | Viewed by 942 | Submission Open
Keywords: minimally invasive spine surgery; artificial intelligence; wearable biometrics; big data; smartphone accelerometer
(This special issue belongs to the Section Orthopedics)
New Updates in Pediatric Gastroenterology
edited by , Alina Stanescu-Popp and Oana Belei
submission deadline 30 Nov 2025 | Viewed by 877 | Submission Open
Keywords: pediatric gastroenterology and hepatology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; esophageal diseases; endoscopy; gut microbiome; inflammatory bowel disease; functional GI disorders; nutritional management; precision medicine; gut– brain axis; transitional care
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Surgical Management of Maxillofacial Fractures and Reconstruction of Facial Deformities
edited by , and Francesco Arcuri
submission deadline 30 Nov 2025 | 1 articles | Viewed by 516 | Submission Open
Keywords: head and neck reconstruction; facial fractures; minimally invasive treatments; facial reconstruction; bioengineering in head and neck disorders; CAD/CAM in maxillo facial trauma and deformities
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Anesthesia and Perioperative Management of Organ Transplants
edited by and Ji-Hye Kwon
submission deadline 30 Nov 2025 | Viewed by 287 | Submission Open
Keywords: liver transplantation; coagulation; reperfusion syndrome; perioperative evaluation; coronary artery disease; CDC; DBD; living donor liver transplant; pulmonary evaluation; hepatorenal syndrome; portopulmonary hypertension
(This special issue belongs to the Section Anesthesiology)
Exploring Cardiomyopathy: Comprehensive Guide to Causes, Symptoms and Care
edited by
submission deadline 30 Nov 2025 | Viewed by 283 | Submission Open
Keywords: cardiomyopathy; heart failure; genetics; hypertrophic cardiomyopathy; dilated cardiomyopathy; left ventricular noncompaction; pediatric cardiomyopathies; cardiac imaging
(This special issue belongs to the Section Cardiology)
Challenges in the Diagnosis and Treatment of Glaucoma
edited by
submission deadline 30 Nov 2025 | Viewed by 245 | Submission Open
Keywords: glaucoma diagnosis; glaucoma progression; glaucoma biomarkers; intraocular pressure (IOP) management; corneal hysteresis; machine learning in glaucoma detection; neuroprotection in glaucoma; surgery and laser therapy
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Neuroprognostication and Outcome Prediction After Cardiac Arrest
edited by
submission deadline 30 Nov 2025 | Viewed by 218 | Submission Open
Keywords: neuroprognostication; cardiac arrest; neurological outcome prediction; biomarkers in brain injury; multimodal prog-nostic tools; EEG monitoring; somatosensory evoked potentials (SSEPs); magnetic resonance imaging (MRI) in prognos-tication; post-cardiac arrest care; hypoxic– ischemic brain injury; withdrawal of life-sustaining treatment (WLST); inten-sive care prognostic strategies
(This special issue belongs to the Section Cardiovascular Medicine)
Minimally Invasive Gastrointestinal Surgery: Clinical Advances and Prospects
edited by Jun Suh Lee
submission deadline 30 Nov 2025 | Viewed by 209 | Submission Open
Keywords: minimally invasive surgery; gastrointestinal surgery; laparoscopic surgery; robotic surgery; surgical innovation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Role of Platelet in Inflammation, Infection, and Immune Response submission deadline 30 Nov 2025 | Viewed by 193 | Submission Open
Keywords: platelets; platelet count; dual antiplatelet therapy; inflammation; thrombosis; inflammation; hemostasis; immune response
(This special issue belongs to the Section Hematology)
Interventional Cardiology: Clinical Advances and Future Perspectives
edited by Antonio Landi and
submission deadline 30 Nov 2025 | Viewed by 189 | Submission Open
Keywords: percutaneous coronary intervention; myocardial infarction; interventional cardiology; cardiac catheterization; coronary artery disease; antithrombotic therapy; intravascular imaging; acute coronary syndrome; chronic coronary syndrome
(This special issue belongs to the Section Cardiology)
Technology and Innovations in Microsurgical Reconstruction: Bridging Challenges in Breast, Lymphatic, and Limb Reconstruction
edited by Gordon K. Lee, and
submission deadline 30 Nov 2025 | Viewed by 181 | Submission Open
Keywords: microsurgery; breast reconstruction; limb reconstruction; perforator flaps; super microsurgery; surgical innovation; reconstructive surgery; lymphedema; tissue engineering; diabetic foot reconstruction; wound healing; cell therapy
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Novel Insights into the Clinical Management of Retinal Detachment
edited by Francesco Sabatino
submission deadline 30 Nov 2025 | Viewed by 157 | Submission Open
Keywords: retinal detachment; oil toxicity; gas tamponade; pars plana vitrectomy; scleral buckle; pneumatic retinopexy; surgical techniques; retinal imaging; retinal displacement
(This special issue belongs to the Section Ophthalmology)
Kidney Transplantation: Recent Advances and Challenges
edited by Jose Torrealba
submission deadline 30 Nov 2025 | Viewed by 125 | Submission Open
Keywords: kidney allograft; pathology; HLA and antibodies; management
(This special issue belongs to the Section Nephrology & Urology)
Clinical Advances in the Management and Treatment of Obesity
edited by
submission deadline 5 Dec 2025 | 1 articles | Viewed by 4615 | Submission Open
Keywords: obesity; therapy; weight loss; diet; surgery; exercise; personalized medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
AI in Maternal Fetal Medicine and Perinatal Management
edited by Ariel Many
submission deadline 5 Dec 2025 | 2 articles | Viewed by 3641 | Submission Open
Keywords: maternal fetal medicine; high-risk pregnancy; perinatal management; artificial intelligence (AI) in obstetrics; fetal growth abnormalities; preterm labor prediction
(This special issue belongs to the Section Obstetrics & Gynecology)
Comprehensive Approaches in Plastic and Reconstructive Surgery
edited by Michael Alfertshofer
submission deadline 7 Dec 2025 | 4 articles | Viewed by 6247 | Submission Open
Keywords: plastic surgery; reconstructive surgery; regenerative medicine; advanced surgical planning; trauma reconstruction; patient-specific solutions; multidisciplinary care
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Clinical Challenges in Obstetrics and Gynecology: Interactions Between Gynecological and Obstetric Disorders, Quality of Life, and Mental Health in Women
edited by and Daniel María Lubián López
submission deadline 10 Dec 2025 | 7 articles | Viewed by 9654 | Submission Open
Keywords: perinatal mental health; gynecological disorders; sexual disorders; women’ s quality of life; obstetric complications; women’ s health; women’ s psychological well-being
(This special issue belongs to the Section Obstetrics & Gynecology)
State of the Art: Updates in Preterm Labor and Preterm Birth
edited by and Moti Gulersen
submission deadline 10 Dec 2025 | 5 articles | Viewed by 8536 | Submission Open
Keywords: prenatal diagnosis; preterm birth; antenatal corticosteroids; cerclage; multiple gestations
(This special issue belongs to the Section Obstetrics & Gynecology)
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