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J. Funct. Biomater., Volume 5, Issue 1 (March 2014), Pages 1-28

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Research

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Open AccessArticle Application of Sub-Micrometer Vibrations to Mitigate Bacterial Adhesion
J. Funct. Biomater. 2014, 5(1), 15-26; doi:10.3390/jfb5010015
Received: 14 January 2014 / Revised: 26 February 2014 / Accepted: 28 February 2014 / Published: 11 March 2014
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Abstract
As a prominent concern regarding implantable devices, eliminating the threat of opportunistic bacterial infection represents a significant benefit to both patient health and device function. Current treatment options focus on chemical approaches to negate bacterial adhesion, however, these methods are in some ways
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As a prominent concern regarding implantable devices, eliminating the threat of opportunistic bacterial infection represents a significant benefit to both patient health and device function. Current treatment options focus on chemical approaches to negate bacterial adhesion, however, these methods are in some ways limited. The scope of this study was to assess the efficacy of a novel means of modulating bacterial adhesion through the application of vibrations using magnetoelastic materials. Magnetoelastic materials possess unique magnetostrictive property that can convert a magnetic field stimulus into a mechanical deformation. In vitro experiments demonstrated that vibrational loads generated by the magnetoelastic materials significantly reduced the number of adherent bacteria on samples exposed to Escherichia coli, Staphylococcus epidermidis and Staphylococcus aureus suspensions. These experiments demonstrate that vibrational loads from magnetoelastic materials can be used as a post-deployment activated means to deter bacterial adhesion and device infection. Full article
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Review

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Open AccessReview The Effects of Uniquely-Processed Titanium on Biological Systems: Implications for Human Health and Performance
J. Funct. Biomater. 2014, 5(1), 1-14; doi:10.3390/jfb5010001
Received: 27 August 2013 / Revised: 26 November 2013 / Accepted: 27 November 2013 / Published: 3 January 2014
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Abstract
Titanium is biocompatible and widely utilized in a variety of applications. Recently, titanium in pico-nanometer scale and soluble form (Aqua Titan) has expanded its use to applied human health and performance. The purpose of this article is to review the current evidence associated
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Titanium is biocompatible and widely utilized in a variety of applications. Recently, titanium in pico-nanometer scale and soluble form (Aqua Titan) has expanded its use to applied human health and performance. The purpose of this article is to review the current evidence associated with specific physiological responses to Aqua Titan-treated materials. In vitro studies have shown that application of Aqua Titan can modify membrane potential and long-term potentiation in isolated hippocampal neurons, suggesting reduced pain memory as a possible mechanism for reported analgesia. Proximal contact with Aqua Titan-treated titanium increased gene expression, protein synthesis, cell growth and adhesion in normal cultured muscle and bone cells, suggesting application for Aqua Titan in clinical implant procedures and wound healing. Evidence for beneficial effects on neuromuscular control of muscle-tendon function and improvements in running economy in human athletes was seen when Aqua Titan-treated tape was applied to the human triceps surae following fatigue induced by prior strenuous exercise. Finally, behavioral responses and effects on the autonomic nervous system to environmental exposure suggest Aqua Titan may promote a mild relaxant, or stress-suppressive response. Together, data suggest exposure to Aqua Titan-treated materials modulates aspects of growth and function in neuronal and other musculoskeletal cells with possible benefits to musculotendinous recovery from exercise and to the systemic response to stress. Full article

Other

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Open AccessCorrection Correction: Koh, L.B., et al. Epoxy Cross-Linked Collagen and Collagen-Laminin Peptide Hydrogels as Corneal Substitutes. J. Funct. Biomater. 2013, 4, 162-177
J. Funct. Biomater. 2014, 5(1), 27-28; doi:10.3390/jfb5010027
Received: 11 March 2014 / Accepted: 12 March 2014 / Published: 17 March 2014
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Abstract It has been brought to our attention very recently that we had an omission error in our methods section of the paper [1]. [...] Full article

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