Biodegradable FeMnSi Sputter-Coated Macroporous Polypropylene Membranes for the Sustained Release of Drugs
Abstract
:1. Introduction
2. Materials and Methods
2.1. Preparation and Characterization of the Macroporous Fe- and FeMnSi-Coated PP Membranes
2.1.1. Sputtering of Fe and FeMnSi on Macroporous PP Membranes
2.1.2. Structural and Magnetic Characterization of the Fe- and FeMnSi-coated PP Membranes
2.1.3. Biodegradability Studies
2.1.4. Cell Culture
2.1.5. MTT Assay
2.2. Functionalization of the Macroporous FeMnSi-Coated PP Membranes
2.3. Characterization and Performance of the Tf-AF488-Loaded Membranes
2.3.1. Distribution of Tf-AF488
2.3.2. Release of Tf-AF488
2.3.3. Tf-AF488 Uptake by Cells
3. Results and Discussion
3.1. Characterization of the Fe- and FeMnSi-Coated Membranes
3.1.1. Structural and Morphological Characterization
3.1.2. Magnetic Characterization
3.1.3. Biodegradability
3.1.4. Cytotoxicity Results
3.2. Transferrin-Alexa Fluor 488 Functionalization of the FeMnSi-Coated Membranes
4. Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Steps (# of Times) | Sample 1 | Sample 2 | Sample 3 |
---|---|---|---|
Loading with Tf-AF488 | 1 | 1 | 3 |
Cleaning with HBSS | 0 | 1 | 1 |
Drying under vacuum | 1 | 1 | 1 |
Stopper | 0 | 1 | 2 |
Drying under vacuum | 0 | 1 | 1 |
Membrane Type | [Fe] (μg L−1) | [Mn] (μg L−1) |
---|---|---|
PP membrane | <10 | <10 |
Fe | <10 | <10 |
Fe-14Mn-4Si | 19 ± 6 | 17 ± 2 |
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Fornell, J.; Soriano, J.; Guerrero, M.; Sirvent, J.D.D.; Ferran-Marqués, M.; Ibáñez, E.; Barrios, L.; Baró, M.D.; Suriñach, S.; Nogués, C.; et al. Biodegradable FeMnSi Sputter-Coated Macroporous Polypropylene Membranes for the Sustained Release of Drugs. Nanomaterials 2017, 7, 155. https://doi.org/10.3390/nano7070155
Fornell J, Soriano J, Guerrero M, Sirvent JDD, Ferran-Marqués M, Ibáñez E, Barrios L, Baró MD, Suriñach S, Nogués C, et al. Biodegradable FeMnSi Sputter-Coated Macroporous Polypropylene Membranes for the Sustained Release of Drugs. Nanomaterials. 2017; 7(7):155. https://doi.org/10.3390/nano7070155
Chicago/Turabian StyleFornell, Jordina, Jorge Soriano, Miguel Guerrero, Juan De Dios Sirvent, Marta Ferran-Marqués, Elena Ibáñez, Leonardo Barrios, Maria Dolors Baró, Santiago Suriñach, Carme Nogués, and et al. 2017. "Biodegradable FeMnSi Sputter-Coated Macroporous Polypropylene Membranes for the Sustained Release of Drugs" Nanomaterials 7, no. 7: 155. https://doi.org/10.3390/nano7070155