Next Article in Journal
Antibiotics: Responding to a Global Challenge
Article Menu

Export Article

Open AccessReview
Antibiotics 2012, 1(1), 1-13; doi:10.3390/antibiotics1010001

Classification Framework and Chemical Biology of Tetracycline-Structure-Based Drugs

1
Italian National Board of Chemists and Italian Chemical Society, Rome, 00187, Italy
2
McGill Nutrition and Performance Laboratory, Department of Oncology, School of Medicine, McGill University, 5252 Maisonneuve Street, Montreal, QC, H4A3S5, Canada
Received: 2 May 2012 / Revised: 21 May 2012 / Accepted: 8 June 2012 / Published: 12 June 2012
View Full-Text   |   Download PDF [485 KB, uploaded 12 June 2012]   |  

Abstract

By studying the literature about tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are well known, especially against bacteria, while against other targets, they are virtually unknown. In other diverse fields of research—such as neurology, oncology and virology—the utility and activity of the tetracyclines are being discovered and are also emerging as new technological fronts. The first aim of this paper is to classify the compounds already used in therapy and prepare the schematic structure that includes the next generation of TCs. The second aim of this work is to introduce a new framework for the classification of old and new TCs, using a medicinal chemistry approach to the structure of those drugs. A fully documented Structure-Activity-Relationship (SAR) is presented with the analysis data of antibacterial and nonantibacterial (antifungal, antiviral and anticancer) tetracyclines. The lipophilicity and the conformational interchangeability of the functional groups are employed to develop the rules for TC biological activity. View Full-Text
Keywords: tetracycline; anthracycline; aminomethylcycline; CMT; fuorocycline; pentacycline; antibiotics; non-antibiotics tetracycline; anthracycline; aminomethylcycline; CMT; fuorocycline; pentacycline; antibiotics; non-antibiotics
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fuoco, D. Classification Framework and Chemical Biology of Tetracycline-Structure-Based Drugs. Antibiotics 2012, 1, 1-13.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antibiotics EISSN 2079-6382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top