Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Rheumatoid Arthritis Diagnosis and DAS28
2.3. Periodontal Diagnosis
2.4. NS-PT
2.5. Serum and Saliva Samples
2.6. Enzyme-Linked Immunosorbent Assay
2.7. Statistical Analysis
2.8. Ethical Issues
3. Results
3.1. Patients
3.2. Periodontal Findings
3.3. RA Activity Level
3.4. CLP and CRP
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Baseline Mean ± SD (Range) | 6 Weeks after NS-PT Mean ± SD (Range) | 12 Weeks after NS-PT Mean ± SD (Range) | p Value | |
---|---|---|---|---|
PD (mm) | 4.0 ± 0.11 (3.7–4.2) | 1.8 ± 0.12 (1.7–2.1) | 1.8 ± 0.1 (1.6–1.9) | <0.0001 * |
CAL (mm) | 2.6 ± 0.14 (2.4–3.1) | 2.0 ± 0.23 (1.8–2.8) | 1.7 ± 0.08 (1.6–1.8) | <0.0001 * |
PESA (mm2) | 556.4 ± 28.8 (487.6–597.0) | 174.1± 14.8 (156.6–208.8) | 161.1 ± 9.1 (150.5–183.5) | <0.0001 ** |
PISA (mm2) | 351.1 ± 29.7 (292.5–398.3) | 16.5 ± 6.7 (6.3–28.9) | 16.5 ± 6.7 (5.5–29.9) | <0.0001 ** |
Baseline Mean ± SD (Range) | At Scaling and Root Planing Mean ± SD (Range) | 6 Weeks after NS-PT Mean ± SD (Range) | 12 Weeks after NS-PT Mean ± SD (Range) | p Value * | |
---|---|---|---|---|---|
OHI | 1.2 ± 0.15 (1.0–1.6) | 0.3 ± 0.04 (0.2–0.4) | 0.3 ± 0.04 (0.2–0.4) | 0.2 ± 0.04 (0.2–0.3) | <0.0001 |
PI | 2.1 ± 0.09 (1.8–2.2) | 0.5 ± 0.03 (0.4–0.5) | 0.5 ± 0.03 (0.4–0.5) | 0.4 ± 0.05 (0.3–0.5) | <0.0001 |
GI | 2.8 ± 0.17 (2.5–3.0) | 1.2 ± 0.1 (1.0–1.5) ** | 0.8 ± 0.35 (0.2–1.3) | 0.6 ± 0.27 (0.0–1.0) | <0.0001 |
BOP | 3.8 ± 0.19 (3.5–4.0) | 0.8 ± 0.09 (0.7–1.0) ** | 0.5 ± 0.20 (0.2–0.8) | 0.4 ± 0.22 (0.0–0.8) | <0.0001 |
Before Treatment Mean ± SD (Range) | 12 Weeks after NS-PT Mean ± SD (Range) | p Value | |
---|---|---|---|
ESR (mm per hour) | 70.5 ± 8.01 (60–82) | 42.3 ± 4.81 (36–49.2) | <0.0001 * |
DAS28 | 5.4 ± 0.47 (4.8–6.0) | 3.2 ± 0.28 (2.8–3.6) | <0.0001 * |
Frequency (%) | Frequency (%) | ||
RA activity level | |||
Low (DAS28: 2.6–3.2) | 0 (0) | 11 (42.3) | |
Moderate (DAS28: 3.2–5.1) | 10 (38.5) | 15 (57.7) | < 0.0001 ** |
High (DAS28: 5.1–8.4) | 16 (61.5) | 0 (0) |
Baseline Mean ± SD (Range) | 6 Weeks after NS-PT Mean ± SD (Range) | 12 Weeks after NS-PT Mean ± SD (Range) | p Value | |
---|---|---|---|---|
C-reactive protein | 1739 ± 383.1 | 861.9 ± 200.1 †† | 521.7 ± 114.9 | |
(1106–2298) | (522.8–663.4) | (331.7–689.5) | <0.0001 * | |
Serum calprotectin | 205.0 ± 114.0 | 87.5 ± 48.6 †† | 66.8 ± 38.1 | |
(90.5–391.1) | (29.3–178.9) | (18.5–141.2) | <0.0001 ** | |
Saliva calprotectin | 234.4 ± 113.4 | 105.6 ± 49.6 †† | 70.6 ± 32.4 | |
(107.3–411.9) | (43.0–197.0) | (20.6–120.5) | <0.0001 ** | |
Calprotectin serum vs. saliva | 0.3564 † | 0.1881 † | 0.7059 † |
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Popoca-Hernández, E.A.; Martínez-Martínez, R.E.; González-Amaro, R.F.; Niño-Moreno, P.d.C.; Ayala-Herrera, J.L.; Jerezano-Domínguez, A.V.; Espinosa-Cristóbal, L.F.; Márquez-Corona, M.d.L.; Espinosa-de Santillana, I.A.; Medina-Solís, C.E. Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental Study. Diseases 2024, 12, 12. https://doi.org/10.3390/diseases12010012
Popoca-Hernández EA, Martínez-Martínez RE, González-Amaro RF, Niño-Moreno PdC, Ayala-Herrera JL, Jerezano-Domínguez AV, Espinosa-Cristóbal LF, Márquez-Corona MdL, Espinosa-de Santillana IA, Medina-Solís CE. Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental Study. Diseases. 2024; 12(1):12. https://doi.org/10.3390/diseases12010012
Chicago/Turabian StylePopoca-Hernández, Elena Aurora, Rita Elizabeth Martínez-Martínez, Roberto Fidencio González-Amaro, Perla del Carmen Niño-Moreno, José Luis Ayala-Herrera, Alberto Vinicio Jerezano-Domínguez, Leon Francisco Espinosa-Cristóbal, María de Lourdes Márquez-Corona, Irene Aurora Espinosa-de Santillana, and Carlo Eduardo Medina-Solís. 2024. "Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental Study" Diseases 12, no. 1: 12. https://doi.org/10.3390/diseases12010012