SUMO Wrestles with Recombination
Abstract
:1. Introduction
1.1. Double-Strand Break Repair
1.2. SUMO
2. SUMO in Recombination
2.1. SUMO in HR
Pathway | Yeast | Human | Function | Effect of sumoylation | Reference |
---|---|---|---|---|---|
NHEJ | Ku70 | KU70 | subunit of Ku complex, protection of DNA ends, recruitment of other NHEJ factors | unknown | [25,64] |
Ku80 | KU80 | subunit of Ku complex, protection of DNA ends, recruitment of other NHEJ factors | unknown | [38,65] | |
Lif1 | XRCC4 | DNA ligation | intracellular localization (human) | [38,66] | |
HR | Mre11 1 | MRE11 | subunit of MRX complex (DSB resection) | unknown | [38] |
Rad50 1 | RAD50 | subunit of MRX complex (DSB resection) | unknown | [38] | |
Xrs2 1 | NBS1 | subunit of MRX complex (DSB resection) | unknown | [38] | |
Sae2 | CtIP | DSB resection | unknown | [38] | |
Rad52 2 | RAD52 | recombination mediator | inhibition of biochemical activities, intranuclear localization, protein stability (yeast) | [42,43] | |
subcellular localization (human) | |||||
RPA 2 | RPA | binding resected DNA tails | recruitment of RAD51 to initiate HR (human) | [48,67] | |
Rad59 2 | stabilization of Rad51 filament, ssDNA annealing | unknown | [67] | ||
Sgs1 | BLM | RecQ-like helicase, resolution of dHJ | Sgs1 sumoylation stimulates recombination at telomeres | [34,68] | |
BLM sumoylation promotes Rad51-dependent recombination | |||||
WRN | RecQ-like helicase, resolution of dHJ | WRN sumoylation affects its nuclear localization | [69,70] | ||
Srs2 | helicase, disruption of Rad51 filament, promoting SDSA | unscheduled sumoylation in | [54] | ||
non-phosphorylatable Srs2 causes recombinational repair defects | |||||
SSA | Rad1 | XPF | subunit of Rad1–Rad10 complex (nuclease activity) | unknown | [38] |
2.1.1. DNA End Resection
2.1.2. Presynaptic Filament Formation
2.1.3. Synaptic Phase
2.1.4. Post-Synaptic Phase
2.2. SUMO in NHEJ
3. The Interplay of HR and SUMO at the Repetitive Sequences
3.1. SUMO and the rDNA
3.2. SUMO and the Telomeres
4. Meiotic Recombination
5. Interplay of Post-Translational Modifications
6. Conclusions
Acknowledgments
References
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Altmannová, V.; Kolesár, P.; Krejčí, L. SUMO Wrestles with Recombination. Biomolecules 2012, 2, 350-375. https://doi.org/10.3390/biom2030350
Altmannová V, Kolesár P, Krejčí L. SUMO Wrestles with Recombination. Biomolecules. 2012; 2(3):350-375. https://doi.org/10.3390/biom2030350
Chicago/Turabian StyleAltmannová, Veronika, Peter Kolesár, and Lumír Krejčí. 2012. "SUMO Wrestles with Recombination" Biomolecules 2, no. 3: 350-375. https://doi.org/10.3390/biom2030350