Table of Contents
Biomolecules, Volume 8, Issue 1 (March 2018)
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Cover Story (view full-size image) The antibiotic crisis has led to a pressing need for alternatives such as antimicrobial peptides [...] Read more. The antibiotic crisis has led to a pressing need for alternatives such as antimicrobial peptides (AMPs). Antimicrobial peptides, also known as host defense peptides, have shown great promise given that the use of AMPs leads to no, or low, resistance developed by bacteria. We discuss the diversity, history and the various mechanisms of action of AMPs. Although many AMPs have been identified and characterized, not many have yet made it into clinical trials, and only a few have been approved by the US Food and Drug Administration (FDA) due to issues with toxicity, protease cleavage and rapid kidney clearance. Some of the recent strategies developed to address these issues, such as chemical modifications of AMPs and the use of delivery systems, are also reviewed in this article. View the paper here.