Autoimmune Haemolytic Anaemia as a Rare and Potentially Serious Complication of Crohn’s Disease in a 11-Year-Old Child—Case Report and Minireview
Abstract
:1. Introduction
2. Case Description
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Gender | Age (Years) | Disease That Occurred First | Time between Diagnosis of CD and AIHA | Scope of CD Changes | Coombs Test | Therapy That Did Not Induce Remission of AIHA | Therapy That Induced Remission of AIHA | CD Treatment at the Time of AIHA Diagnosis | Comorbidities | |
---|---|---|---|---|---|---|---|---|---|---|
Eliam, 1993 [16] | M | 41 | AIHA | 7 years | Colitis (cecum and ascending colon) | Positive | CS | Splenectomy | - | Primary sclerosing cholangitis |
Hochman, 2002 [6] | M | 11 | CD | 2 years | Ileocolitis | Positive | CS Mesalamine 6-MP | MTX | Mesalamine | - |
Ng, 2004 [10] | M | 44 | CD | 2 years | Ileitis with perianal abscess and fistula | Positive | Mesalamine | CS AZA | CS | - |
Plikat, 2005 [17] | M | 29 | Simultaneously | 0 | Ileocolitis with proximal disease (duodenum) | Positive | CS MTX Cyclosporine anti-TNF | Subtotal colectomy | - | - |
Tsiopulos, 2009 [13] | M | 57 | AIHA | * | Ileocolitis | Positive | * | CS | - | Thrombosis of ophthalmic artery |
Kallel, 2009 [18] | M | 21 | CD | 9 months | Ileocolitis with Perianal fistula | Positive | Mesalamine | CS | Mesalamine | Primary sclerosing cholangitis |
Park, 2014 [4] | F | 41 | CD | 4 years | Ileitis | Negative | * | CS | Mesalamine | - |
Al.-Ansari, 2021 [14] | M | 63 | CD | * | * | Negative | * | CS | Infliximab (second induction dose) | Hypertension |
Cheah, 2021 [15] | M | 21 | CD | * | Left-sided disease | Positive | CS | rituximab | vedolizumab (first maintenance dose) | - |
Toplicanin, 2022 [2] | F | 36 | AIHA | 3 months | Colitis | Positive | CS anti-TNF AZA | vedolizumab | - | - |
Our patient | F | 11 | CD | 2 years | Ileocecal region and from the mid-ascending colon to the mid-transverse colon | Negative | CS Cyclosporine | Right-sided colectomy | Infliximab (fourth maintenance dose) | - |
Day of Hospitalization | WBC (4.50–13.50 K/mcL) | RBC (3.80–5.00 Million Cells/mcL) | HGB (12.0–15.0 g/dL) | HCT (34.0–43.0%) | MCV (73.0–95.0 fl) | MCH (25.0–32.0 pg) | MCHC (32.0–37.0 g/dL) | PLT (175–345 K/mcL) | |
---|---|---|---|---|---|---|---|---|---|
First AIHA episode | 1 | 8.38 | 4.96 | 10.6 ↓ | 34.0 | 68.5 ↓ | 21.4 ↓ | 31.2 ↓ | 533 ↑ |
3 | 9.36 | 5.03 ↑ | 10.9 ↓ | 36.2 | 72.0 ↓ | 21.7 ↓ | 30.1 ↓ | 447 ↑ | |
4 | 7.2 | 4.42 | 9.8 ↓ | 31.3 ↓ | 70.8 ↓ | 22.2 ↓ | 31.3 ↓ | 418 ↑ | |
5 | 9.16 | 2.86 ↓ | 6.5 ↓ | 21.4 ↓ | 74.8 | 23.8 ↓ | 31.8 ↓ | 462 ↑ | |
RBC transfusion | |||||||||
6 | 23.35 ↑ | 1.75 ↓ | 4.5 ↓ | 13.6 ↓ | 77.7 | 25.7 | 33.1 | 253 | |
8 | 22.89 ↑ | 3.51 ↓ | 8.7 ↓ | 23.8 ↓ | 67.8 ↓ | 24.8 ↓ | 36.6 | 498 ↑ | |
9 | 25.01 ↑ | 3.44 ↓ | 8.5 ↓ | 23.6 ↓ | 68.6 ↓ | 24.7 ↓ | 36.0 | 558 ↑ | |
11 | 32.73 ↑ | 3.43 ↓ | 8.6 ↓ | 24.3 ↓ | 70.8 ↓ | 25.1 | 35.4 | 570 ↑ | |
13 | 34.96 ↑ | 3.86 | 9.9 ↓ | 28.1 ↓ | 72.8 ↓ | 25.6 | 35.2 | 657 ↑ | |
Second AIHA episode | 1 | 9.24 | 3.42 ↓ | 9.1 ↓ | 26.1 ↓ | 76.3 | 26.6 | 34.9 | 411 ↑ |
2 | 7.23 | 2.28 ↓ | 5.9 ↓ | 17.4 ↓ | 73.6 | 25.9 | 33.9 | 300 | |
RBC transfusion | |||||||||
3 | 4.87 | 3.91 | 10.5 ↓ | 31.1 ↓ | 79.5 | 26.9 | 33.8 | 353 ↑ | |
5 | 6.53 | 3.27 ↓ | 9.0 ↓ | 25.6 ↓ | 78.3 | 27.5 | 35.2 | 340 | |
8 | 8.27 | 3.00 ↓ | 8.2 ↓ | 24.9 ↓ | 83.0 | 27.3 | 32.9 | 334 | |
10 | 9.89 | 2.49 ↓ | 6.8 ↓ | 20.5 ↓ | 82.3 | 27.3 | 33.2 | 237 | |
RBC transfusion | |||||||||
10 | 13.01 | 3.80 | 10.9 ↓ | 31.5 ↓ | 82.9 | 28.7 | 34.6 | 254 | |
11 | 8.09 | 2.21 ↓ | 6.2 ↓ | 18.0 ↓ | 81.4 | 28.1 | 34.4 | 195 | |
12 | 9.24 | 3.88 | 11.1 ↓ | 31.7 ↓ | 81.7 | 28.6 | 35.0 | 215 | |
Hemicolectomy | |||||||||
13 | 14.94 | 3.12 ↓ | 9.0 ↓ | 26.1 ↓ | 83.7 | 28.8 | 34.5 | 182 | |
13 | 9.89 | 2.68 ↓ | 7.7 ↓ | 22.5 ↓ | 84.0 | 28.7 | 34.2 | 187 | |
RBC transfusion | |||||||||
15 | 12.32 | 3.81 | 10.8 ↓ | 31.6 ↓ | 82.9 | 28.3 | 34.2 | 243 | |
21 | 13.88 ↑ | 4.08 | 12.1 | 35.8 | 87.7 | 29.7 | 33.8 | 377 ↑ | |
28 | 14.51 ↑ | 3.68 ↓ | 10.8 ↓ | 31.7 ↓ | 86.1 | 29.3 | 34.1 | 372 ↑ | |
35 | 9.38 | 4.34 | 12.5 | 38.4 | 88.5 | 28.8 | 32.6 | 300 |
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Dybowska, A.; Krogulska, A. Autoimmune Haemolytic Anaemia as a Rare and Potentially Serious Complication of Crohn’s Disease in a 11-Year-Old Child—Case Report and Minireview. Children 2023, 10, 1698. https://doi.org/10.3390/children10101698
Dybowska A, Krogulska A. Autoimmune Haemolytic Anaemia as a Rare and Potentially Serious Complication of Crohn’s Disease in a 11-Year-Old Child—Case Report and Minireview. Children. 2023; 10(10):1698. https://doi.org/10.3390/children10101698
Chicago/Turabian StyleDybowska, Aleksandra, and Aneta Krogulska. 2023. "Autoimmune Haemolytic Anaemia as a Rare and Potentially Serious Complication of Crohn’s Disease in a 11-Year-Old Child—Case Report and Minireview" Children 10, no. 10: 1698. https://doi.org/10.3390/children10101698