Sleep Respiratory Disorders in Children and Adolescents with Cystic Fibrosis and Primary Ciliary Dyskinesia
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. SRDs in CF Patients
3.2. SRD in PCD Patients
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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CF | ||||||
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Authors | Type of Study | Number of Patients | Mean Age (yrs) | Variable Assessed | Main Findings | References |
Cohen-Cymberknoh et al., 2019 | Observational | 39 | 11.1 | Lung function, sleep disorders and their correlation with QoL | Sleep impairment correlated with disease severity and affected QoL. | [4] |
Isaiah et al., 2019 | Retrospective case series | 41 | 11.6 | Pulmonary function, polysomnographic variables | FEV1 was the best predictor of sleep hypoxemia in children with CF and referred for polysomnography. | [14] |
Perin et al., 2012 | Prospective | 51 | 25.1 ± 6.7 | Cardiac and pulmonary function, and polysomnographic variables | Desaturation was common and not associated with obstructive events during sleep. It can be predicted by awake resting SpO2 < 94% | [15] |
Papale et al., 2020 | Observational | 31 | 17.4 ± 5.2 | Lung function and sleep disorders | LCI has a higher effectiveness in predicting nocturnal hypoxemia in stable patients with CF than traditional parameter of lung function such as FEV 1 . | [18] |
Spicuzza L. et al. | Case-control | 40 | 6.3 ± 5.6 | Polysomnographic variables and sleep quality | Early occurrence of obstructive sleep apnea in children with CF in stable condition. | [19] |
Milross et al., 2002 | Observational | 31 | 27 ± 8 | First-night effect of polysomnographic measurements on nocturnal oxygenation | A single-night with polysomnographic measurements in patients with CF provided information on nocturnal oxygenation and respiratory disturbance. | [23] |
De Castro Silva et al., 2009 | Prospective | 30 | 12.8 | Polysomnographic variables | Desaturation during sleep can be predicted by FEV1 < 64% | [25] |
Paranjape et al., 2015 | Observational | 43 | 9.6 ± 3.6 | Analysis of breathing patterns, gas exchange and polysomnographic variables. | Children with CF demonstrated lower oxyhemoglobin saturation and a higher proportion of inspiratory flow limitation, compared with control group | [27] |
PCD | ||||||
Authors | Type of study | Number of patients | Mean age (yrs) | Variable assessed | Main findings | References |
Cohen-Cymberknoh et al., 2019 | Observational | 39 | 11.1 | Lung function, sleep disorders and their correlation with QoL | Sleep impairment correlated with disease severity and affected QoL. | [4] |
Oktem et al., 2013 | Observational Case control | 29 | 10.9 | Sleep quality and sleep disorders | Patients with PCD have decreased sleep quality and higher rate of OSAS compared to controls | [39] |
Santamaria et al., 2014 | Observational Case control | 60 | 12.3 | Lung function, nasal endoscopy and sleep disorders | Nocturnal desaturation was linked with lung function and structure abnormalities | [40] |
Clinical Parameters Predicting of Sleep Respiratory Disorders | Monitoring |
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Papale, M.; Manti, S.; Presti, S.; Mollica, F.; Parisi, G.F.; Leonardi, S. Sleep Respiratory Disorders in Children and Adolescents with Cystic Fibrosis and Primary Ciliary Dyskinesia. Children 2023, 10, 1707. https://doi.org/10.3390/children10101707
Papale M, Manti S, Presti S, Mollica F, Parisi GF, Leonardi S. Sleep Respiratory Disorders in Children and Adolescents with Cystic Fibrosis and Primary Ciliary Dyskinesia. Children. 2023; 10(10):1707. https://doi.org/10.3390/children10101707
Chicago/Turabian StylePapale, Maria, Sara Manti, Santiago Presti, Federico Mollica, Giuseppe F. Parisi, and Salvatore Leonardi. 2023. "Sleep Respiratory Disorders in Children and Adolescents with Cystic Fibrosis and Primary Ciliary Dyskinesia" Children 10, no. 10: 1707. https://doi.org/10.3390/children10101707