Successful Use of Multidisciplinary Palliative Care in the Outpatient Treatment of Disseminated Histoplasmosis in an HIV Positive Child
Abstract
:1. Introduction
2. Methods—Case Report
3. Case Report—Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
AIDS | acquired immunodeficiency syndrome |
ART | antiretroviral therapy |
CALHIV | children and adolescents living with HIV |
CD4 | cluster of differentiation 4 immune cells |
COE | Center of Excellence |
DOT | directly observed therapy |
GMS | Grocott-Gomori’s (or Gömöri) methenamine silver stain |
Hcc | Histoplasma capsulatum var capsulatum |
Hcd | Histoplasma capsulatum var duboisii |
HIV | Human Immunodeficiency Virus |
IV | intravenous |
LMIC | low- and middle-income country |
PDH | progressive disseminated histoplasmosis |
OPAT | outpatient parental antimicrobial therapy |
VL | viral load |
WBC | white blood cell |
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Diagnostic Information | Result |
---|---|
Body mass index | 12.1 kg/m2 1 |
Mid-upper arm circumference | 12.5 cm 2 |
Absolute lymphocyte cell count | 0.3 × 109/L |
Hemoglobin | 2.98 mmol/L |
CD4 count | 24 cells/µL |
HIV viral load | 196,658 cp/mL |
Chest radiograph | Bilateral infiltrates with mild hilar adenopathy |
Skull radiograph | No abnormalities |
Laboratory Value | At Presentation 1 | 6 Months after Switch to ABC-3TC-LPV/r | 12 Months after Switch to ABC-3TC-LPV/r | 4 Years after Presentation; Treatment with ABC-3TC-DTG |
---|---|---|---|---|
CD4 count (cells/µL) | 24 | 213 | 422 | 404 |
HIV viral load (cp/mL) | 196,658 | 35 | <20 | <20 |
Hemoglobin (mmol/L) | 2.98 | 5.52 | 6.14 | 9.06 |
White blood cell count (×109/L) | 3.43 | 4.63 | 5.5 | No data available |
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Lopez, A.; Bacha, J.; Kovarik, C.; Campbell, L. Successful Use of Multidisciplinary Palliative Care in the Outpatient Treatment of Disseminated Histoplasmosis in an HIV Positive Child. Children 2021, 8, 273. https://doi.org/10.3390/children8040273
Lopez A, Bacha J, Kovarik C, Campbell L. Successful Use of Multidisciplinary Palliative Care in the Outpatient Treatment of Disseminated Histoplasmosis in an HIV Positive Child. Children. 2021; 8(4):273. https://doi.org/10.3390/children8040273
Chicago/Turabian StyleLopez, Alison, Jason Bacha, Carrie Kovarik, and Liane Campbell. 2021. "Successful Use of Multidisciplinary Palliative Care in the Outpatient Treatment of Disseminated Histoplasmosis in an HIV Positive Child" Children 8, no. 4: 273. https://doi.org/10.3390/children8040273