From Single Microparticles to Microfluidic Emulsification: Fundamental Properties (Solubility, Density, Phase Separation) from Micropipette Manipulation of Solvent, Drug and Polymer Microspheres
Abstract
:1. Introduction
1.1. The Micropipette Technique
1.2. Microfluidics
1.3. Ibuprofen Formulations
1.4. The Main Aims of This Work
2. Materials and Methods
2.1. Materials
2.2. Preparation and Recrystallization of Ibuprofen H
2.3. Thermal Characterization of Ibuprofen
2.4. The Micropipette Technique
2.5. Microdroplet Dissolution: Calculation of Diffusion Coefficient of Solvent or Drug in the Aqueous Phase
2.6. Formation and Investigation of Microdroplets/Microparticles
2.6.1. Preparation of Samples
2.6.2. Solvent Microdroplet Formation and Dissolution
2.6.3. Polymer Microsphere and Polymer Microsphere-Drug Formation
2.6.4. Formation and Dissolution of Pure Ibuprofen Microdroplets
2.7. Microfluidic Emulsification for PLGA Microsphere Production
2.7.1. Single Channel System
2.7.2. Multichannel System
3. Results and Discussion
3.1. Solvent Droplet-Dissolution
3.2. PLGA Microsphere Formation in PBS
3.3. Ibuprofen Encapsulation in PLGA Microparticles
3.4. Ibuprofen Phase-Separation from DCM/PLGA
3.5. New Measure of Ibp Diffusion Coefficient and Dissolution Time from DCM/Ibp Microparticle Dissolution into PBS
3.6. Ibuprofen Dissolution into a Micellar Sink
3.7. Micromanipulation and DSC Showed That Ibp Microparticles Are Possibly Supercooled Liquids
3.8. Microfluidic Single Channel Scale-Up
3.9. Multichannel Microfluidic Scale-Up
4. Summary and Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Kinoshita, K.; Parra, E.; Hussein, A.; Utoft, A.; Walke, P.; De Bruijn, R.; Needham, D. From Single Microparticles to Microfluidic Emulsification: Fundamental Properties (Solubility, Density, Phase Separation) from Micropipette Manipulation of Solvent, Drug and Polymer Microspheres. Processes 2016, 4, 49. https://doi.org/10.3390/pr4040049
Kinoshita K, Parra E, Hussein A, Utoft A, Walke P, De Bruijn R, Needham D. From Single Microparticles to Microfluidic Emulsification: Fundamental Properties (Solubility, Density, Phase Separation) from Micropipette Manipulation of Solvent, Drug and Polymer Microspheres. Processes. 2016; 4(4):49. https://doi.org/10.3390/pr4040049
Chicago/Turabian StyleKinoshita, Koji, Elisa Parra, Abdirazak Hussein, Anders Utoft, Prasad Walke, Robin De Bruijn, and David Needham. 2016. "From Single Microparticles to Microfluidic Emulsification: Fundamental Properties (Solubility, Density, Phase Separation) from Micropipette Manipulation of Solvent, Drug and Polymer Microspheres" Processes 4, no. 4: 49. https://doi.org/10.3390/pr4040049