Effect of Probiotics Lactobacillus rhamnosus and Lactobacillus plantarum on Caries and Periodontal Diseases: A Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Literature Search
- Population: humans of all ages;
- Intervention: adjunctive option in non-surgical periodontal therapy and caries;
- Comparator: healthy adults/adolescents/children;
- Outcomes: possible effects of orally administered L. rhamnosus and L. plantarum (alone or in several combinations) on periodontitis/gingivitis/peri-implant mucositis and tooth decay.
2.2. Eligibility Criteria
2.3. Data Extraction
2.4. Quality Assessment
3. Results
3.1. Study Selection
3.2. Detailed Results
3.3. Quality Assessment Results
4. Discussion
4.1. Dental Caries and Probiotics
4.2. Periodontal Disease and Probiotics
4.3. Limitations of the Study
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
Appendix A
Authors/Year | Conclusions |
---|---|
Oda Y. et al., 2023 [26] | Daily consumed yogurt mixed with L. rhamnosus L8020 may stop the progression of periodontitis in subjects with intellectual disability. |
Pørksen CJ. et al., 2023 [27] | Daily lozenge of L. rhamnosus, L. paracasei and arginine may reduce dental caries increment in children aged 5–9 y.o. |
Ranjith A et al., 2022 [28] | Mouthwash with L. rhamnosus, L. acidophilus, B. longum and S. boulardii may be an adjunct to mechanical plaque removal in patients with stage II periodontitis. |
Santana SI et al., 2022 [29] | Gel and lozenges containing L. rhamnosus, L. paracasei and B. lactis may promote additional clinical benefits to mechanical debridement in patients with peri-implant mucositis. |
Morales A. et al., 2021 [30] | L. rhamnosus failed in enhancing additional clinical benefits in patients with stage III periodontitis compared to placebo. |
Pudgar P. et al., 2021 [31] | The adjunctive use of probiotics containing L. plantarum and L. brevis in chronic periodontitis results in a lower gingival bleeding and a higher number of residual diseased sites when compared with SRP and placebo. |
Yuki O. et al., 2019 [32] | Regular consumed yogurt mixed with L. rhamnosus L8020 may lower the risk of periodontal disease in subjects with intellectual disability. |
Alanzi A. et al., 2018 [33] | Combination of L. rhamnosus and B. lactis may serve as a simple adjunct to standard oral care for promoting the oral health in adolescents aged 13–15 y.o. |
Morales A. et al., 2018 [34] | Patients receiving SRP and sachets with L. rhamnosus showed a similar reduction in cultivable bacteria and clinical parameters as placebo or azithromycin. |
Keller MK. et al., 2018 [35] | Tablets with L. rhamnosus and L. curvatus are able to reduce BOP and the flow of GCF, but not microbiological parameters in patients with moderate gingivitis. |
Mongardini C. et al., 2017 [36] | The adjunctive use of L. plantarum and L. brevis does not significantly improve the clinical outcomes of professionally administered plaque removal in patients with peri-implant mucositis. |
Montero E. et al., 2017 [37] | The adjunctive use of L. plantarum, L. brevis and P. acidilactici improve the subgingival microbiota in patients with gingivitis. |
Iwasaki K. et al., 2016 [38] | Daily capsule containing L. plantarum may reduce PPD in patients during SPT. |
Morales A. et al., 2016 [39] | The adjunct of sachets with L. rhamnosus to SRP lead to a greater reduction in PPD than placebo. |
Toiviainen A. et al., 2015 [40] | Lozenges with L. rhamnosus and B. lactis could decrease both PI and GI, without changing the oral microbiota in healthy young adults. |
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Authors/Year | Q1 | Q2 | Q3 | Tot |
---|---|---|---|---|
Oda Y. et al., 2023 [26] | 1 | 0 | 0 | 1 |
Pørksen CJ. et al., 2023 [27] | 2 | 2 | 1 | 5 |
Ranjith A et al., 2022 [28] | 1 | 1 | 0 | 2 |
Santana SI et al., 2022 [29] | 2 | 2 | 0 | 4 |
Morales A. et al., 2021 [30] | 2 | 2 | 0 | 4 |
Pudgar P. et al., 2021 [31] | 2 | 2 | 1 | 5 |
Yuki O. et al., 2019 [32] | 2 | 2 | 0 | 4 |
Alanzi A. et al., 2018 [33] | 1 | 2 | 1 | 4 |
Morales A. et al., 2018 [34] | 2 | 2 | 1 | 5 |
Keller MK. et al., 2018 [35] | 1 | 1 | 1 | 3 |
Mongardini C. et al., 2017 [36] | 2 | 2 | 1 | 5 |
Montero E. et al., 2017 [37] | 2 | 1 | 1 | 4 |
Iwasaki K. et al., 2016 [38] | 2 | 1 | 1 | 4 |
Morales A. et al., 2016 [39] | 2 | 1 | 0 | 3 |
Toiviainen A. et al., 2015 [40] | 1 | 2 | 1 | 4 |
Authors/Year | Population (Age)/ Characteristics | Microorganism | Time of Administration | Aim |
---|---|---|---|---|
Oda Y. et al., 2023 [26] | n = 41 (N/A)/intellectual disability | L. rhamnosus | 3 months | Periodontitis |
Pørksen CJ. et al., 2023 [27] | n = 343 (5–9)/Healthy | L. rhamnosus, L. paracasei, arginine | 10–12 months | Caries |
Ranjith A. et al., 2022 [28] | n = 60 (N/A)/Stage II periodontitis | L. rhamnosus, L. acidophilus, B. longum, S. boulardii | 1 month | Periodontitis |
Santana SI et al., 2022 [29] | n = 36 (N/A)/Peri-implant mucositis | L. rhamnosus, L. paracasei, B. lactis | 3 months | Peri-implant mucositis |
Morales A. et al., 2021 [30] | n = 47 (≥35)/Stage III periodontitis | L. rhamnosus | 3 months | Periodontitis |
Pudgar P. et al., 2021 [31] | n = 40 (25–80)/Stage III-IV periodontitis | L. plantarum, L. brevis | 3 months | Periodontitis |
Yuki O. et al., 2019 [32] | n = 23 (20–45)/intellectual disability | L. rhamnosus | 3 months | Periodontitis |
Alanzi A. et al., 2018 [33] | n = 101 (13–15)/Healthy | L. rhamnosus, B. lactis | 1 month | Gingivitis |
Morales A. et al., 2018 [34] | n = 47 (≥35)/Stage III periodontitis | L. rhamnosus | 3 months | Periodontitis |
Keller MK. et al., 2018 [35] | n = 47 (≥25)/Healthy | L. rhamnosus, L. curvatus | 1 month | Gingivitis |
Mongardini C. et al., 2017 [36] | n = 20(≥46)/Peri-implant mucositis | L. plantarum, L. brevis | 1.5 months | Peri-implant mucositis |
Montero E. et al., 2017 [37] | n = 59(18–55)/Healthy | L. plantarum, L. brevis, P. acidilactici | 1.5 months | Gingivitis |
Iwasaki K. et al., 2016 [38] | n = 39 (≥60)/Periodontitis | L. plantarum | 3 months | Periodontitis |
Morales A. et al., 2016 [39] | n = 28 (≥40)/Periodontitis | L. rhamnosus | 3 months | Periodontitis |
Toiviainen A. et al., 2015 [40] | n = 62 (≥21)/Healthy | L. rhamnosus, B. lactis | 1 month | Gingivitis |
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D’Agostino, S.; Valentini, G.; Iarussi, F.; Dolci, M. Effect of Probiotics Lactobacillus rhamnosus and Lactobacillus plantarum on Caries and Periodontal Diseases: A Systematic Review. Dent. J. 2024, 12, 102. https://doi.org/10.3390/dj12040102
D’Agostino S, Valentini G, Iarussi F, Dolci M. Effect of Probiotics Lactobacillus rhamnosus and Lactobacillus plantarum on Caries and Periodontal Diseases: A Systematic Review. Dentistry Journal. 2024; 12(4):102. https://doi.org/10.3390/dj12040102
Chicago/Turabian StyleD’Agostino, Silvia, Giulia Valentini, Francesca Iarussi, and Marco Dolci. 2024. "Effect of Probiotics Lactobacillus rhamnosus and Lactobacillus plantarum on Caries and Periodontal Diseases: A Systematic Review" Dentistry Journal 12, no. 4: 102. https://doi.org/10.3390/dj12040102