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Proceedings 2017, 1(10), 1070; doi:10.3390/proceedings1101070

Pelargonium endlicherianum Fenzl. Root Extract Suppresses Cell Proliferation of Prostate Cancer Cells

1
Faculty of Pharmacy, Erciyes University, Kayseri 38030, Turkey
2
Department of Food Engineering, Erciyes University Engineering Faculty, Kayseri 38030, Turkey
3
Erciyes University, Kayseri 38030, Turkey
4
Kayseri 38030, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November, 2017.
*
Author to whom correspondence should be addressed.
Published: 15 November 2017
Download PDF [140 KB, uploaded 15 November 2017]

Abstract

Cancer cells are refractory to most forms of chemotherapy. Conventional and alternative drugs, such as herbal extracts, have been developed to target cancer cells. This study aims to test the cytotoxic effects of Pelargonium endlicherianum root extracts on prostate cancer cells. In vitro cytotoxic activities of the methanolic and ethanolic root extracts (0–150 µg/mL) were screened against androgen dependent independent (PC-3) prostate cancer cell lines by MTT assay. Ethanolic root extract induced a significant decrease in cell viability characterized by 100 < IC50 < 150 µg/mL. The results of this study support the efficacy of P. endlicherianum as an anticancer agent for prostate cancer and a potential adjuvant treatment to current chemotherapeutic agents used in the treatment of prostate tumors. Further studies of the effects of individual flavonoids alone and in combination with each other and with currently used therapies are needed.
Keywords: Pelargonium endlicherianum; cancer; MTT assay Pelargonium endlicherianum; cancer; MTT assay
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Eren, S.; Bekci, H.; Basaran, G.S.; Karatoprak, G.S.; Cumaoglu, A. Pelargonium endlicherianum Fenzl. Root Extract Suppresses Cell Proliferation of Prostate Cancer Cells. Proceedings 2017, 1, 1070.

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