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Abstract

Pelargonium endlicherianum Fenzl. Root Extract Suppresses Cell Proliferation of Prostate Cancer Cells †

by
Selda Eren
1,
Hatice Bekci
2,
Guzide Satır Basaran
3,
Gokce Seker Karatoprak
4 and
Ahmet Cumaoglu
3,*
1
Faculty of Pharmacy, Erciyes University, Kayseri 38030, Turkey
2
Department of Food Engineering, Erciyes University Engineering Faculty, Kayseri 38030, Turkey
3
Department of Biochemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38030, Turkey
4
Department of Pharmacognocy, Faculty of Pharmacy, Erciyes University, Kayseri 38030, Turkey
*
Author to whom correspondence should be addressed.
†
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Proceedings 2017, 1(10), 1070; https://doi.org/10.3390/proceedings1101070
Published: 15 November 2017
(This article belongs to the Proceedings of Proceedings of the 2nd International Conference on Natural Products for Cancer Prevention and Therapy)
Versions Notes

Abstract

:
Cancer cells are refractory to most forms of chemotherapy. Conventional and alternative drugs, such as herbal extracts, have been developed to target cancer cells. This study aims to test the cytotoxic effects of Pelargonium endlicherianum root extracts on prostate cancer cells. In vitro cytotoxic activities of the methanolic and ethanolic root extracts (0–150 µg/mL) were screened against androgen dependent independent (PC-3) prostate cancer cell lines by MTT assay. Ethanolic root extract induced a significant decrease in cell viability characterized by 100 < IC50 < 150 µg/mL. The results of this study support the efficacy of P. endlicherianum as an anticancer agent for prostate cancer and a potential adjuvant treatment to current chemotherapeutic agents used in the treatment of prostate tumors. Further studies of the effects of individual flavonoids alone and in combination with each other and with currently used therapies are needed.

Conflicts of Interest

The authors declare no conflict of interest.
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MDPI and ACS Style

Eren, S.; Bekci, H.; Basaran, G.S.; Karatoprak, G.S.; Cumaoglu, A. Pelargonium endlicherianum Fenzl. Root Extract Suppresses Cell Proliferation of Prostate Cancer Cells. Proceedings 2017, 1, 1070. https://doi.org/10.3390/proceedings1101070

AMA Style

Eren S, Bekci H, Basaran GS, Karatoprak GS, Cumaoglu A. Pelargonium endlicherianum Fenzl. Root Extract Suppresses Cell Proliferation of Prostate Cancer Cells. Proceedings. 2017; 1(10):1070. https://doi.org/10.3390/proceedings1101070

Chicago/Turabian Style

Eren, Selda, Hatice Bekci, Guzide Satır Basaran, Gokce Seker Karatoprak, and Ahmet Cumaoglu. 2017. "Pelargonium endlicherianum Fenzl. Root Extract Suppresses Cell Proliferation of Prostate Cancer Cells" Proceedings 1, no. 10: 1070. https://doi.org/10.3390/proceedings1101070

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