Assessment of Antioxidant and Cytotoxic Activity of Known Antioxidants Compared to Neopterin †
Toxicology Department, Faculty of Pharmacy, Hacettepe University, Ankara 06000, Turkey
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Authors to whom correspondence should be addressed.
†
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Proceedings 2017, 1(10), 1071; https://doi.org/10.3390/proceedings1101071
Published: 15 November 2017
(This article belongs to the Proceedings of Proceedings of the 2nd International Conference on Natural Products for Cancer Prevention and Therapy)
Abstract
:Free radicals and other reactive oxygen species (ROS) are constantly formed in the human body. Free-radical mechanisms have been implicated in the pathology of several human diseases. Free radicals are generated physiologically during immune activation. Neopterin, an early marker of immune activation is released from monocyte-macrophages with the induction of interferon-gamma. Its biological levels are known to be increased in different types of pathologies including cancer. Neopterin is also known to be related with oxidative stress. In this study, the antioxidant effect of neopterin and silymarin, melatonin and homocystein was evaluated by NO, SO, and DPPH radicals scavenging assays. Possible cytotoxic effects of the compounds were evaluated in 3 different cell lines by MTT and LDH assays. According to the results all the compounds have the radical scavenging activities. Therefore, none of them have a significant cytotoxic potential. However, only neopterin has a significant proliferative effect at very high concentrations. The results should be confirmed and reevaluated by in vivo and in vitro experiments.
Keywords: neopterin; silymarin; melatonin; homocysteine; antioxidant; cytotoxicity
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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MDPI and ACS Style
Girgin, G.; Sabuncuoğlu, S.; Ünal, A.Z.; Baydar, T. Assessment of Antioxidant and Cytotoxic Activity of Known Antioxidants Compared to Neopterin. Proceedings 2017, 1, 1071. https://doi.org/10.3390/proceedings1101071
AMA Style
Girgin G, Sabuncuoğlu S, Ünal AZ, Baydar T. Assessment of Antioxidant and Cytotoxic Activity of Known Antioxidants Compared to Neopterin. Proceedings. 2017; 1(10):1071. https://doi.org/10.3390/proceedings1101071
Chicago/Turabian StyleGirgin, Gözde, Suna Sabuncuoğlu, Ayşe Zeynep Ünal, and Terken Baydar. 2017. "Assessment of Antioxidant and Cytotoxic Activity of Known Antioxidants Compared to Neopterin" Proceedings 1, no. 10: 1071. https://doi.org/10.3390/proceedings1101071
