A Study on the Synthesis and Anticancer Activities of Novel 6-Methoxy Flavonyl Piperazine Derivatives †
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara 06100, Turkey
*
Author to whom correspondence should be addressed.
†
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Proceedings 2017, 1(10), 1073; https://doi.org/10.3390/proceedings1101073
Published: 17 November 2017
(This article belongs to the Proceedings of Proceedings of the 2nd International Conference on Natural Products for Cancer Prevention and Therapy)
Abstract
:Cancer is an extensive and complicated family of malignancies that can affect virtually every part of the body. It is reported that over 1.2 million new cases are diagnosed every year. In most of the patients, meaningful clinical results cannot be achieved by the currently available cancer therapies and we still need efficient probes as drugs to cure. Natural products have long been a source of antitumor drugs and new natural products are reasonable to be expected as promising leads for antitumor drug discovery. Among natural products, flavonoids are a group of polyphenolic compounds present in plants and they have attracted considerable attention by virtue of their diverse and interesting biological activities such as anti-inflammatory, neuroprotection and antitumor activity. In this study, we describe the synthesis of a new series of N-substituted 6-methoxyflavonyl piperazine derivatives (Formula) with the aim of testing their cytotoxic and anticancer activities. The structural evaluation of the synthesized compounds was based on the 1H NMR, Mass and elementary analysis data. The synthesized compounds are under investigation for their anticancer activities.
N-substituted 6-methoxyflavonyl
piperazine derivatives.Conflicts of Interest
The authors declare no conflict of interest.
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MDPI and ACS Style
Ceylan-Ünlüsoy, M.; Bozdağ-Dündar, O. A Study on the Synthesis and Anticancer Activities of Novel 6-Methoxy Flavonyl Piperazine Derivatives. Proceedings 2017, 1, 1073. https://doi.org/10.3390/proceedings1101073
AMA Style
Ceylan-Ünlüsoy M, Bozdağ-Dündar O. A Study on the Synthesis and Anticancer Activities of Novel 6-Methoxy Flavonyl Piperazine Derivatives. Proceedings. 2017; 1(10):1073. https://doi.org/10.3390/proceedings1101073
Chicago/Turabian StyleCeylan-Ünlüsoy, Meltem, and Oya Bozdağ-Dündar. 2017. "A Study on the Synthesis and Anticancer Activities of Novel 6-Methoxy Flavonyl Piperazine Derivatives" Proceedings 1, no. 10: 1073. https://doi.org/10.3390/proceedings1101073
