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Abstract

Cytokine Production, Ferritin Levels and Bone Mineral Density in Healthy Postmenopausal Women †

by
Bolaji Lilian Ilesanmi-Oyelere
1,2,*,
Michelle McConnell
3,
Sonya Mros
3,
Jane Coad
1,
Nicole C. Roy
2,4,5 and
Marlena Cathorina Kruger
1,2,6
1
Massey School of Food and Advanced Technology, College of Sciences, Massey University, Palmerston North 4442, New Zealand
2
Riddet Institute, Massey University, Palmerston North 4442, New Zealand
3
Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand
4
Food Nutrition & Health, AgResearch, Palmerston North 4410, New Zealand
5
High-Value Nutrition National Science Challenge, Auckland 1142, New Zealand
6
School of Health Sciences, College of Health, Massey University, Palmerston North 4442, New Zealand
*
Author to whom correspondence should be addressed.
†
Presented at the 2018 Nutrition Society of New Zealand Annual Conference, Auckland, New Zealand, 28–30 November 2018.
Proceedings 2019, 8(1), 28; https://doi.org/10.3390/proceedings2019008028
Published: 12 March 2019
(This article belongs to the Proceedings of 2018 Annual Meeting of the Nutrition Society of New Zealand)
Versions Notes
Published: 12 March 2019
Background: Cytokines, chemokines and CRP are known inflammatory markers. However, cytokines such as interleukin (IL-1β), (IL-6) and tumour necrosis factor (TNF-α) have been reported to interfere with both the bone resorption and bone formation process. IL-10 but not IL-33 has been linked to lower ferritin levels and anemia. In this study, we hypothesized that cytokine levels will be higher in women with low bone mineral density (BMD) due to the actions of elevated levels of these pro-inflammatory cytokines in inducing osteoclast formation during senescence.
Methods: In this cross-sectional study, eighty-six postmenopausal women aged 54–81 years were enrolled for the study. BMD of the hip, lumbar spine and femoral neck were assessed using dual-energy X-ray absorptiometry (DXA). Cytokine and ferritin levels were obtained from the plasma of fasting blood samples. Cytokines and ferritin levels were measured using LEGENDplex™ Multi-Analyte Flow Assay and electrochemiluminescence immunoassay “ECLIA” respectively.
Results: Cytokines (IFNa2, IFN-y, IL-12p70, IL-33) and MCP-1 levels were significantly higher in the osteoporotic than the osteopenic and/or normal groups. Meanwhile CRP levels were significantly lower in women with osteoporosis (p = 0.04) than those with osteopenia and normal groups. Hip BMD values were significantly lower in women with high/detectable values of IL-1β (p = 0.02) and IL-6 (p = 0.03) compared to women with non-detectable values. Similarly, women with high/detectable values of IL-1β had significantly lower spine BMD than those with non-detectable values of IL-1β (p = 0.03). In addition, ferritin levels of women with high/detectable values of IL-10 (p = 0.01) and IL-33 (p = 0.02) were significantly lower than those with non-detectable values. There was no association between TNF-α and BMDs of the hip and lumbar spine.
Conclusions: High levels of cytokines and MCP-1 in apparently healthy postmenopausal women is associated with bone health issues. In addition, increase in levels of IL-10 and IL-33 may be associated with anemia in this age group.

Supplementary Materials

The poster is available online at www.mdpi.com/2504-3900/8/1/28/s1.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

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MDPI and ACS Style

Ilesanmi-Oyelere, B.L.; McConnell, M.; Mros, S.; Coad, J.; Roy, N.C.; Kruger, M.C. Cytokine Production, Ferritin Levels and Bone Mineral Density in Healthy Postmenopausal Women. Proceedings 2019, 8, 28. https://doi.org/10.3390/proceedings2019008028

AMA Style

Ilesanmi-Oyelere BL, McConnell M, Mros S, Coad J, Roy NC, Kruger MC. Cytokine Production, Ferritin Levels and Bone Mineral Density in Healthy Postmenopausal Women. Proceedings. 2019; 8(1):28. https://doi.org/10.3390/proceedings2019008028

Chicago/Turabian Style

Ilesanmi-Oyelere, Bolaji Lilian, Michelle McConnell, Sonya Mros, Jane Coad, Nicole C. Roy, and Marlena Cathorina Kruger. 2019. "Cytokine Production, Ferritin Levels and Bone Mineral Density in Healthy Postmenopausal Women" Proceedings 8, no. 1: 28. https://doi.org/10.3390/proceedings2019008028

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