Postural Orthostatic Tachycardia Syndrome (POTS) as an Adverse Event to the Human Papilloma Virus (HPV) Vaccine and Its Relationship with Ehlers–Danlos Syndrome (EDS)
Abstract
:1. Introduction
2. Case Presentation Section
3. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Use of 9-Valent Human Papillomavirus (HPV) Vaccine: Updated HPV Vaccination Recommendations of the Advisory Committee on Immunization Practices—PubMed. Available online: https://pubmed.ncbi.nlm.nih.gov/25811679/ (accessed on 30 October 2023).
- A Review of Clinical Trials of Human Papillomavirus Prophylactic Vaccines—ScienceDirect. Available online: https://www.sciencedirect.com/science/article/pii/S0264410X12009516?via%3Dihub (accessed on 30 October 2023).
- Grubb, B.P. Postural Tachycardia Syndrome. Circulation 2008, 117, 2814–2817. [Google Scholar] [CrossRef] [PubMed]
- Benarroch, E.E. Postural Tachycardia Syndrome: A Heterogeneous and Multifactorial Disorder. Mayo Clin. Proc. 2012, 87, 1214–1225. [Google Scholar] [CrossRef] [PubMed]
- Dysautonomia International: Postural Orthostatic Tachycardia Syndrome. Available online: https://www.dysautonomiainternational.org/page.php?ID=30 (accessed on 30 October 2023).
- Sheldon, R.S.; Grubb, B.P.; Olshansky, B.; Shen, W.-K.; Calkins, H.; Brignole, M.; Raj, S.R.; Krahn, A.D.; Morillo, C.A.; Stewart, J.M.; et al. 2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm. 2015, 12, e41–e63. [Google Scholar] [CrossRef] [PubMed]
- Bourne, K.M.; Chew, D.; Stiles, L.; Shaw, B.H.; Shibao, C.A.; Okamoto, L.E.; Garland, E.M.; Gamboa, A.; Peltier, A.; Diedrich, A.; et al. Postural Orthostatic Tachycardia Syndrome is Associated with Significant Employment and Economic Loss. J. Intern. Med. 2021, 290, 203–212. [Google Scholar] [CrossRef] [PubMed]
- Zhao, S.; Tran, V.H. Postural Orthostatic Tachycardia Syndrome. In StatPearls; StatPearls Publishing: St. Petersburg, FL, USA, 2024; Available online: http://www.ncbi.nlm.nih.gov/books/NBK541074/ (accessed on 6 February 2024).
- Tv, P.; Tran, T.T.; Hao, H.T.; Hau, N.T.H.; Jain, N.; Reinis, A. Postural orthostatic tachycardia syndrome-like symptoms following COVID-19 vaccination: An overview of clinical literature. Hum. Antibodies 2023, 31, 9–17. [Google Scholar] [CrossRef] [PubMed]
- Arana, J.; Mba-Jonas, A.; Jankosky, C.; Lewis, P.; Moro, P.L.; Shimabukuro, T.T.; Cano, M. Reports of Postural Orthostatic Tachycardia Syndrome After Human Papillomavirus Vaccination in the Vaccine Adverse Event Reporting System. J. Adolesc. Health Off. Publ. Soc. Adolesc. Med. 2017, 61, 577–582. [Google Scholar] [CrossRef] [PubMed]
- Valent, P.; Akin, C.; Arock, M.; Brockow, K.; Butterfield, J.H.; Carter, M.C.; Castells, M.; Escribano, L.; Hartmann, K.; Lieberman, P.; et al. Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal. Int. Arch. Allergy Immunol. 2011, 157, 215–225. [Google Scholar] [CrossRef] [PubMed]
- Butts, B.; Fischer, P.R.; Mack, K.J. Human Papillomavirus Vaccine and Postural Orthostatic Tachycardia Syndrome: A Review of Current Literature. J. Child Neurol. 2017, 32, 956–965. [Google Scholar] [CrossRef]
- Chandler, R.; Juhlin, K.; Fransson, J.; Caster, O.; Ir, E.; Norén, G.N. Current Safety Concerns With Human Papillomavirus Vaccine: A Cluster Analysis of Reports in VigiBase®. Drug Saf. 2016, 40, 81–90. [Google Scholar] [CrossRef]
- Barboi, A.; Gibbons, C.H.; Axelrod, F.B.; Benarroch, E.E.; Biaggioni, I.; Chapleau, M.W.; Chelimsky, G.; Chelimsky, T.; Cheshire, W.P.; Claydon, V.E.; et al. Human Papillomavirus (HPV) Vaccine and Autonomic Disorders: A Position Statement From the American Autonomic Society. Auton. Neurosci. 2020, 223, 102550. [Google Scholar] [CrossRef]
- Afrin, L.B.; Dempsey, T.T.; Weinstock, L.B. Post-Hpv-Vaccination Mast Cell Activation Syndrome: Possible Vaccine-Triggered Escalation of Undiagnosed Pre-Existing Mast Cell Disease? Vaccines 2022, 10, 127. [Google Scholar] [CrossRef] [PubMed]
- Molderings, G.J.; Brettner, S.; Homann, J.; Afrin, L.B. Mast Cell Activation Disease: A Concise Practical Guide for Diagnostic Workup and Therapeutic Options. J. Hematol. Oncol. 2011, 4, 10. [Google Scholar] [CrossRef]
- Weinstock, L.B.; Brook, J.B.; Myers, T.L.; Goodman, B. Successful Treatment of Postural Orthostatic Tachycardia and Mast Cell Activation Syndromes Using Naltrexone, Immunoglobulin and Antibiotic Treatment. BMJ Case Rep. 2018, 2018, bcr-2017-221405. [Google Scholar] [CrossRef] [PubMed]
- Mast Cell Activation Disorder Archives. Available online: https://www.ehlers-danlos.org/what-is-eds/information-on-eds/mast-cell-activation-disorder (accessed on 12 January 2024).
- Roma, M.; Marden, C.L.; De Wandele, I.; Francomano, C.A.; Rowe, P.C. Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome. Auton. Neurosci. 2018, 215, 89–96. [Google Scholar] [CrossRef]
- Gensemer, C.; Burks, R.; Kautz, S.; Judge, D.P.; Lavallee, M.; Norris, R.A. Hypermobile Ehlers-Danlos syndromes: Complex phenotypes, challenging diagnoses, and poorly understood causes. Dev. Dyn. Off. Publ. Am. Assoc. Anat. 2021, 250, 318–344. [Google Scholar] [CrossRef]
- Blitshteyn, S. Postural tachycardia syndrome following human papillomavirus vaccination. Eur. J. Neurol. 2014, 21, 135–139. [Google Scholar] [CrossRef]
- Ozawa, K.; Hineno, A.; Kinoshita, T.; Ishihara, S.; Ikeda, S. Suspected Adverse Effects After Human Papillomavirus Vaccination: A Temporal Relationship Between Vaccine Administration and the Appearance of Symptoms in Japan. Drug Saf. 2017, 40, 1219–1229. [Google Scholar] [CrossRef] [PubMed]
- Kavi, L.; Gammage, M.D.; Grubb, B.P.; Karabin, B.L. Postural tachycardia syndrome: Multiple symptoms, but easily missed. Br. J. Gen. Pract. 2012, 62, 286–287. [Google Scholar] [CrossRef]
- Shaw, B.H.; Stiles, L.E.; Bourne, K.; Green, E.A.; Shibao, C.A.; Okamoto, L.E.; Garland, E.M.; Gamboa, A.; Diedrich, A.; Raj, V.; et al. The face of postural tachycardia syndrome—Insights from a large cross-sectional online community-based survey. J. Intern. Med. 2019, 286, 438–448. [Google Scholar] [CrossRef]
- Knoop, I.; Gu, S.; Fareghzadeh, S.; Jones, A.S.K.; Gall, N.; Moss-Morris, R. Exploring the complexities of illness identity and symptom management in seeking a diagnostic label of postural orthostatic tachycardia syndrome (POTS): An inductive approach. Br. J. Health Psychol. 2023, 29, 297–316. [Google Scholar] [CrossRef]
- Grigoriou, E.; Boris, J.R.; Dormans, J.P. Postural orthostatic tachycardia syndrome (POTS): Association with Ehlers-Danlos syndrome and orthopaedic considerations. Clin. Orthop. 2015, 473, 722–728. [Google Scholar] [CrossRef] [PubMed]
Degree of Tilt | 17 February 2021 1020 | 17 February 2021 1019 | 17 February 2021 1018 |
---|---|---|---|
70 Degrees | 70 Degrees | 70 Degrees | |
Heart Rate | 144 bpm | 145 bpm | 136 bpm |
Blood Pressure | 115/82 | 122/90 | 132/84 |
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Schipperijn, N.; Wijesinghe, M.; Romo, A.; Brooks, B. Postural Orthostatic Tachycardia Syndrome (POTS) as an Adverse Event to the Human Papilloma Virus (HPV) Vaccine and Its Relationship with Ehlers–Danlos Syndrome (EDS). Reports 2024, 7, 36. https://doi.org/10.3390/reports7020036
Schipperijn N, Wijesinghe M, Romo A, Brooks B. Postural Orthostatic Tachycardia Syndrome (POTS) as an Adverse Event to the Human Papilloma Virus (HPV) Vaccine and Its Relationship with Ehlers–Danlos Syndrome (EDS). Reports. 2024; 7(2):36. https://doi.org/10.3390/reports7020036
Chicago/Turabian StyleSchipperijn, Nicole, Megan Wijesinghe, Aisa Romo, and Benjamin Brooks. 2024. "Postural Orthostatic Tachycardia Syndrome (POTS) as an Adverse Event to the Human Papilloma Virus (HPV) Vaccine and Its Relationship with Ehlers–Danlos Syndrome (EDS)" Reports 7, no. 2: 36. https://doi.org/10.3390/reports7020036