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Advances in Veterinary Dermatology — Atopic Dermatitis in Dogs and...
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Advances in Veterinary Dermatology — Atopic Dermatitis in Dogs and Cats

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3593

Special Issue Editors

Prof. Dr. Ha-Jung Kim

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Guest Editor
Department of Veterinary Medicine, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea
Interests: atopic dermatitis; allergy; dog; immunology; oncology; internal medicine
Prof. Dr. Byeong-Teck Kang

E-Mail Website
Guest Editor
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Interests: atopic dermatitis; allergy; dog; animal model
Prof. Dr. Rosanna Marsella

E-Mail Website
Guest Editor
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 SW 16th Ave., Gainesville, FL 32610, USA
Interests: atopic dermatitis; allergy; dog; animal model

Special Issue Information

Dear Colleagues,

The population of pets has increased significantly in recent years, and so have concerns about their health. Skin diseases, including allergies and recurrent infections common causes of visits to veterinary clinics for dogs. Environmental and food allergies are increasing in prevalence, and similar to human allergies, they are characterized by pruritus and relapsing inflammatory lesions. The multifactorial developing mechanism may also contribute to its complicacy.

Chronic allergies are often challenging to manage due to relapse and refractory manners. Therefore, many companies have tried to investigate effective treatments worldwide. Additionally, many researchers have dedicated efforts to identifying unique alternatives without side effects for long-term use. It is thus necessary to examine new paradigms for chronic allergies for pets.

This Special Issue aims to present recent investigations of canine and feline allergic skin diseases which include showing new evidence of mechanisms and the development of new trials for the management of these diseases.

Prof. Dr. Ha-Jung Kim
Prof. Dr. Byeong-Teck Kang
Prof. Dr. Rosanna Marsella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • atopic dermatitis
  • pruritic skin disease
  • dog
  • cat
  • developing mechanism
  • allergy

Published Papers (3 papers)

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Research

17 pages, 6494 KiB  
Article
Studies Using Antibodies against Filaggrin and Filaggrin 2 in Canine Normal and Atopic Skin Biopsies
by Rosanna Marsella, Kim Ahrens and Rachel Wilkes
Animals 2024, 14(3), 478; https://doi.org/10.3390/ani14030478 - 1 Feb 2024
Viewed by 676
Abstract
Filaggrin is important for the skin barrier and atopic dermatitis. Another filaggrin-like protein, filaggrin 2, has been described. We evaluated antibodies against both filaggrins in normal and atopic skin biopsies from dogs before and after allergen challenges (D0, D1, D3 and D10). Filaggrins [...] Read more.
Filaggrin is important for the skin barrier and atopic dermatitis. Another filaggrin-like protein, filaggrin 2, has been described. We evaluated antibodies against both filaggrins in normal and atopic skin biopsies from dogs before and after allergen challenges (D0, D1, D3 and D10). Filaggrins expression was evaluated by immunohistochemistry and Western blot. We used PCR to investigate changes in filaggrin gene expression. Effects of group (p = 0.0134) and time (p = 0.0422) were shown for the intensity of filaggrin staining. Only an effect of group was found for filaggrin 2 (p = 0.0129). Atopic samples had higher intensity of staining than normal dogs [filaggrin on D3 (p = 0.0155) and filaggrin 2 on D3 (p = 0.0038) and D10 (p < 0.0001)]. Atopic samples showed increased epidermal thickness after allergen exposure (D3 vs. D0, p = 0.005), while normal dogs did not. In atopic samples, significant increased gene expression was found for filaggrin overtime but not for filaggrin 2. Western blot showed an increase in filaggrin 2 on D3. A small size band (15 kD) containing a filaggrin sequence was found in Western blots of atopic samples only. We conclude that atopic skin reacts to allergen exposure by proliferating and increasing filaggrin production but that it also has more extensive filaggrin degradation compared to normal skin. Full article
(This article belongs to the Special Issue Advances in Veterinary Dermatology — Atopic Dermatitis in Dogs and Cats)
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14 pages, 2887 KiB  
Article
Efficacy of Allogeneic and Xenogeneic Exosomes for the Treatment of Canine Atopic Dermatitis: A Pilot Study
by Sang-Won Kim, Kyung-Min Lim, Ssang-Goo Cho, Bokyeong Ryu, C-Yoon Kim, Seon Young Park, Kyungmin Jang, Jae Heon Jung, Cheolhyoung Park, Chulhee Choi and Jung-Hyun Kim
Animals 2024, 14(2), 282; https://doi.org/10.3390/ani14020282 - 16 Jan 2024
Cited by 1 | Viewed by 1479
Abstract
Canine atopic dermatitis (CAD) is a genetically predisposed inflammatory pruritic skin disease. The available treatments for CAD have several adverse effects and vary in efficacy, indicating the need for the development of improved treatments. In this study, we aimed to elucidate the therapeutic [...] Read more.
Canine atopic dermatitis (CAD) is a genetically predisposed inflammatory pruritic skin disease. The available treatments for CAD have several adverse effects and vary in efficacy, indicating the need for the development of improved treatments. In this study, we aimed to elucidate the therapeutic effects of allogeneic and xenogeneic exosomes on CAD. Six laboratory beagle dogs with CAD were randomly assigned to three treatment groups: control, canine exosome (cExos), or human exosome (hExos) groups. Dogs in the cExos and hExos groups were intravenously administered 1.5 mL of cExos (5 × 1010) and hExos (7.5 × 1011) solutions, respectively, while those in the control group were administered 1.5 mL of normal saline three times per week for 4 weeks. Skin lesion score and transepidermal water loss decreased in cExos and hExos groups compared with those in the control group. The exosome treatments decreased the serum levels of inflammatory cytokines (interferon-γ, interleukin-2, interleukin-4, interleukin-12, interleukin-13, and interleukin-31) but increased those of anti-inflammatory cytokines (interleukin-10 and transforming growth factor-β), indicating the immunomodulatory effect of exosomes. Skin microbiome analysis revealed that the exosome treatments alleviated skin bacterial dysbiosis. These results suggest that allogeneic and xenogeneic exosome therapy may alleviate CAD in dogs. Full article
(This article belongs to the Special Issue Advances in Veterinary Dermatology — Atopic Dermatitis in Dogs and Cats)
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11 pages, 2263 KiB  
Article
Remote Monitoring of Canine Patients Treated for Pruritus during the COVID-19 Pandemic in Florida Using a 3-D Accelerometer
by Michael Canfield, Robert P. Lavan, Timberly Canfield, Tonya Springer, Rob Armstrong, Gal Gingold, Jennifer Thomas and Bridgette Sampeck
Animals 2023, 13(24), 3875; https://doi.org/10.3390/ani13243875 - 16 Dec 2023
Viewed by 783
Abstract
The medical management of chronic canine pruritic dermatologic conditions is challenging and often frustrating. This is a report that shows one way of aiding the management of pruritic dogs using a remote monitoring device. It is often difficult for veterinarians to get dog [...] Read more.
The medical management of chronic canine pruritic dermatologic conditions is challenging and often frustrating. This is a report that shows one way of aiding the management of pruritic dogs using a remote monitoring device. It is often difficult for veterinarians to get dog owners to return to the clinic once a dog is treated. It is possible that a 3-D accelerometer device could provide information to the clinic staff on the success or failure of a pruritus treatment plan while the dog was cared for at home. Eighty-seven dogs and their owners came to a Florida dermatology specialty clinic or its general practice hospital to be evaluated and treated for pruritus. An ANIMO® 3-D accelerometer was placed on the collar of dogs diagnosed and treated for pruritus. Dogs that completed this study were monitored for 120 days (4 months). The ANIMO smart phone application monitored a dog’s daily scratching, shaking, sleeping, activity, and resting and summarized this information in a daily report visible on the pet owner’s smart phone. An additional variable (grooming minutes per day) could be seen by the study team that was not yet available in the app. The use of a 3-D accelerometer enabled veterinarians to continuously monitor dogs at home when they were being treated for itching. Clinic staff kept in touch with the owners by phone and could change therapy or bring the dog back for a recheck if problems were seen. Daily reports were combined into line charts that showed plots of scratching, shaking, grooming, and sleeping over four months. Veterinarians were able to remotely monitor dogs that had been treated for pruritus for up to four months through use of a collar-borne monitoring device. Dog owners and clinic staff used the daily summaries accessible through a smart phone application. Dogs seemed to tolerate the device well because of its small size, light weight, long battery life, and unobtrusive nature. Full article
(This article belongs to the Special Issue Advances in Veterinary Dermatology — Atopic Dermatitis in Dogs and Cats)
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