Autoimmune and Inflammatory Rheumatic Diseases: Potential Biomarkers, Antibodies Response and New Therapies
A special issue of Antibodies (ISSN 2073-4468). This special issue belongs to the section "Antibody-Based Diagnostics".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 25780
Special Issue Editor
Interests: inflammatory rheumatic diseases; autoimmunity; T-cell response
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autoimmune and inflammatory rheumatic diseases encompass a broad spectrum of conditions with severe disabling effects and potential organ damage. They mainly include systemic lupus erythematosus (SLE), vasculitis, rheumatoid arthritis, and spondylarthritis. Antibodies play a very important role in these diseases. In fact, several are important for pathogenesis, as exemplified by anti-native DNA antibodies associated with kidney damage in SLE, anti-neutrophil cytoplasmic antibodies (ANCAs) playing a key role in the pathogenesis of small-vessel vasculitis, and anti-citrullinated cyclic peptide (CCP) antibodies associated with an erosive course of rheumatoid arthritis. Anti-nuclear antibodies (ANAs), ANCAs, and anti-CCP antibodies also have a fundamental role in the diagnosis of these diseases. From a therapeutic point of view, monoclonal antibodies such as anti-B-cell, anti-cytokine, and anti-interleukin biologics have been used for the treatment of these conditions for the last 20 years, significantly changing the quality of life and prognosis of patients. However, important unmet needs still remain, such as the unavailability of biomarkers for diagnosis and prediction of the response to various biologics as well as the availability of more effective antibodies that may be used to target newly discovered pro-inflammatory molecules.
We invite contributions from experienced scientists and clinicians to this Special Issue of Antibodies, which hopes to further advance knowledge in this field to reduce the suffering and disability of patients with autoimmune and inflammatory rheumatic diseases.
Dr. Marino Paroli
Guest Editor
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Keywords
- antibodies and arthritis
- antibodies and connective tissue diseases
- anti-phospholipid syndrome
- anti-COVID-19 response in rheumatic diseases
- biomarkers in autoimmune/rheumatic diseases
- biologics
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