The Advances and Applications of Optogenetics, Volume II
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 263
Special Issue Editors
Interests: characterization of NMDARs; light-gated receptors; multimodal imaging agents; fluorescent probes; novel viral vectors
Interests: channelrhodopsins; optogenetics; neuroscience; cardiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
When Karl Deisseroth coined “optogenetics” in 2006, he envisioned using genetically encoded actuators to control the membrane potential and, thus, cellular excitability with light. Recruiting microbial rhodopsins to this end has brought into force a revolution in neuroscience, led to clinical trials to cure blindness and is considered for the treatment of many psychiatric and neurological disorders. Other light-sensitive protein domains, mostly of plant origin, have been harnessed for photo regulation of gene expression, protein activity, oligomerization and trafficking. These efforts have been complemented by engineering proteins to bind photoswitchable ligands. Finally, an array of photosensors responsive to physiological changes in the membrane voltage or intracellular concentrations of specific ions have been developed, making feasible all-optical interrogation of cellular activity. This Special Issue focuses on recent advances in the ever-broadening and exciting field of optogenetics that are expected to boost both fundamental research and clinical practice.
The first volume of this Special Issue can be accessed here: https://www.mdpi.com/journal/applsci/special_issues/Advances_Optogenetics.
Dr. Shai Berlin
Dr. Elena G. Govorunova
Guest Editors
Manuscript Submission Information
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Keywords
- optogenetics
- photoswitching
- photocontrol
- all-optical electrophysiology
- microbial rhodopsins
- ion channels
- LOV domains
- phytochromes
- membrane potential
- gene expression
- oligomerization
- intracellular trafficking
- protein-protein interaction
- signaling
