Advances of Hyaluronan in Tissue Regeneration

Dear Colleagues,

Hyaluronan is one of the major polysaccharides in the extracellular matrix ubiquitously present in the joints and other parts of the human body, including the skin, eyes, bones, and cartilage. This polymer is essential for normal homeostasis and is implicated in multiple inflammatory and degenerative diseases and cancer. It interacts with different hyaladherins, receptors, and growth factors and modulates the major phases of tissue regeneration, including inflammation, proliferation (fibrogenesis and angiogenesis), and remodeling to restore the structure and function of the tissue. Remarkably, the hyaluronan-enriched matrices affect cellular processes. Thus, this sugar molecule has received significant attention in biomedical research, and cutting-edge discoveries in hyaluronan-based medical devices (e.g., hydrogels, injections, dermal fillers) and drug discovery (biologics, small molecules, peptides) for a wide range of therapeutic purposes promise a revolutionary change in regenerative medicine.

This Special Issue will publish high-quality original research papers and review articles on breakthrough applied research exploring the importance of hyaluronan in tissue regeneration. The emphasis should be given to the therapeutic application of hyaluronan-based medical products in different degenerative diseases and studies elucidating the role of hyaluronan and hyaluronan-binding proteins in the underlying mechanisms of cellular process of tissue regeneration. The following topics will be covered in this Special Issue:

• Hyaluronan signaling in tissue regeneration;
• Wound healing;
• Hyaluronan impact on inflammation and degenerative diseases;
• Hyaluronan mechanobiology;
• Stem cells;
• Biomedical application of hyaluronan-based medical products in tissue regeneration.

Dr. Kaustuv Basu
Prof. Dr. Paraskevi Heldin
Dr. Davide Vigetti
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• hyaluronan
• tissue regeneration
• wound healing
• cell signaling
• hydrogel
• dermal filler
• stem cell
• inflammation
• degenerative disease
• regenerative medicine