Stem Cells for Regenerative Medical Engineering

Dear Colleagues,

Stem cell engraftment has been suggested as a therapy to improve tissue injury repair in disease states or as a replacement therapy for endogenous cells that harbor a mutation. Technological advances in pluripotent stem cells (PSCs) have revolutionized the field of regenerative medicine, providing new opportunities for the development of novel therapies for a wide range of diseases. PSCs, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), possess the unique ability to differentiate into any cell type in the body, making them ideal candidates for cell replacement therapy. The use of PSCs for regenerative medicine has gained significant momentum in recent years, and numerous ongoing clinical trials utilize these cells in various applications.

In addition to PSCs, primary stem cells can be isolated from patients’ tissues and then grown under the appropriate conditions to achieve cell expansion. Primary cell culture is the most widely practiced and cost-effective method to generate a large number of stem cells directly from patients. Culture methods of primary stem cells have reached remarkable achievements over the past several years. Thus, primary stem cells are also highly sought-after products to keep up with demands for basic research and regenerative medicine.  

This Special Issue titled "Stem Cells for Regenerative Medical Engineering" aims to highlight the current status of PSC- and primary-based regenerative therapies and their potential for regenerative medicine.

One of the major challenges in stem cell therapy is the generation of stem cells with high quality. Therefore, this Special Issue will feature innovative approaches to improve PSC differentiation protocols and primary cell culture to ensure the production of stem cells with bio-physiological functions and safety for transplantation. 

Moreover, this Special Issue will cover the latest advancements in stem-cell-based preclinical (animal models) and clinical trials, including their safety and efficacy data, as well as challenges and opportunities in their translation to the clinic.

Overall, this Special Issue will present a comprehensive overview of the current state of stem-cell-based regenerative therapies and their potential for clinical translation. The Special Issue will offer a platform for experts to share their insights and experience, paving the way for the development and use of safe and effective stem-cell-based therapies for the benefit of patients globally.

Dr. Hongmei Mou
Guest Editor

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• pluripotent stem cells
• primary stem cells
• regenerative medicine
• tissue engineering
• cell therapy
• differentiation