Intelligent Nanomaterials and Nanorobots for Disease Diagnosis and Treatment

Dear Colleagues,

With the rapid development and wide applications of nanotechnology, Intelligent Nanomaterials and Nanorobots have been applied to local diagnoses and targeted therapies for patients with various diseases including cancer, diabetes, inflammatory disorders, and cardiovascular diseases. In comparison with conventional nanomaterials in biofluids, Intelligent Nanomaterials and Nanorobots can effectively convert diverse energy sources into movement and force, allowing effective self-propulsion in complex biological environments and physiological barriers. Therefore, Intelligent Nanomaterials and Nanorobots hold great potential for efficient cargo loading, controllable cargo delivery, stimuli-triggered cargo release, deeper tumor tissue penetration, and enhanced cargo accumulation in tumor tissues, exhibiting an exciting prospect for disease diagnosis and treatment. The core structure of Intelligent Nanomaterials and Nanorobots should include the following elements: (i) accurate transport to a target; (ii) the specific identification of various specific microenvironment or signal, which will trigger cascade transformations leading to target recognition; (iii) the effective delivery of therapeutic or diagnostic payloads to a target.

This Special Issue emphasizes the construction of novel Intelligent Nanomaterials and Nanorobots, with a special focus on their potential advantages and applications for local diagnosis and targeted therapy.

Dr. Wenjun Li
Guest Editor

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• preparation and applications of novel intelligent nanomaterials and nanorobots
• driving mode and driving forces for intelligent nanomaterials and nanorobots
• drug delivery in complex biological environment and physiological barriers
• sensing systems and payload delivery
• advanced functionality including internal and external stimuli-responsiveness, switch functionality
• optical imaging, magnetic imaging, ultrasound imaging, photoacoustic imaging, radionuclide imaging and biosensors
• self-propulsion and controllable navigation
• applications disease treatment, including chemotherapy, photothermal therapy, photodynamic therapy, chemodynamic therapy, immunotherapy, and multimodal therapy
• targeted therapy of various diseases including cancer, diabetes, inflammatory disorders, and cardiovascular diseases