Multi-Omics of Extremophilic Organisms

Dear Colleagues,

Extremophiles are fascinating organisms that inhabit environments which are intolerably hostile or even lethal for other life forms. They grow in habitats that do not appear to be suitable for life: very low to extremely high pH (0 to 12), pressures of up to 110 MPa, salt lakes, frozen water and hot volcanic niches at 122 °C, etc. Some of these organisms have shown that they are not only able to tolerate these conditions, but even require them for their survival, growth, and metabolism.

In the face of climate change and rising temperatures, increasing dryness and soil salinity, altered bioremediation and waste and pollution management, research on extremophiles exploring the biology and adaptation of these organisms to extreme conditions is of crucial importance to cope with environmental changes. The molecular uniqueness and the biotechnological potential of species from the extremes of life have also driven intense activity in genomics and multi-omics research aimed at screening for novel proteins and enzymes offering advantages over those from less-tolerant counterparts. Along with unravelling adaptive mechanisms, multi-omics (genomics, transcriptomics, proteomics, metabolomics, phenomics, etc.) of extremophiles hold the potential to contribute to the development of strategies at the gene, protein, metabolic, phenotypic etc. level, ultimately leading to biotechnological innovations.

This Special Issue welcomes submissions of original research and review manuscripts focusing on the application of multi-omics to answer questions concerning the adaptation biology of extremophiles, and to explore the molecular basis of gene and protein stability and the activity and post-translational modifications of physicochemical parameters at extreme values. The ultimate goal is to achieve a precise overview of this novel and interdisciplinary field of microbiology, providing information about the status of this emerging and promising field of research.

Dr. Gorji Marzban
Dr. Donatella Tesei
Guest Editors

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• extremophiles
• integrative analysis
• systems biology
• stress biology
• extreme environmental conditions
• biotechnologic application

Title: Unraveling Extremophiles: A Multi-Omics Exploration of Horizontal Gene transfer and its role in adaptations to Extreme Environments
Author: Dodamani
Highlights: The extremophiles thrive in harsh weather conditions Unravel the molecular mechanism of microbial adaptations extreme environment The factors like heat shock proteins and cold shock proteins play role in adaptations