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Biology
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Free Radicals in Biology and Medicine
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Free Radicals in Biology and Medicine

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 2374

Special Issue Editors

Dr. Ankush Prasad

E-Mail Website
Guest Editor
Department of Biophysics, Faculty of Science, Palacký University, 77900 Olomouc, Czech Republic
Interests: non-invasive imaging method for oxidative stress; free radicals in biology and medicine; ultra-weak photon emission
Special Issues, Collections and Topics in MDPI journals
Dr. Deepak Kumar Yadav

E-Mail Website
Guest Editor
Department of Chemistry, University of California, Davis, CA, USA
Interests: structural & molecular biochemistry; RNA degradation; bio-molecular interaction; ROS-oxidative stress & antioxidants; Ca2+ channel
Dr. Pavel Pospíšil

E-Mail Website
Guest Editor
Department of Biophysics, Faculty of Science, Palacký University, Olomouc, Czech Republic
Interests: reactive oxygen species in photosystem II; free radicals in biology and biomedicine; EPR spin-trapping spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Free radicals are highly reactive molecules that can damage cells and contribute to various diseases. They are produced as a byproduct of normal cellular processes, as well as from external sources such as but not limited to pollution and radiation. Antioxidants are molecules that can neutralize free radicals and protect cells from damage. They can be found in foods such as fruits and vegetables, as well as produced by the body. A balance between free radical and antioxidant levels is important for maintaining good health, and an imbalance can lead to cellular damage and disease.

The special issue of "Free Radicals in Biology and Medicine" focuses on the latest advances in the field of free radicals and their impact on biology and medicine. We welcome contributions in the form of original research and review articles that cover all aspects related to free radicals in biology and medicine. These include reactive oxygen, nitrogen, and sulfur species, as well as the analysis methodologies used to understand their production, cellular targets, and mechanisms of action. Also, we welcome contributions on the role of antioxidant defenses, both enzymatic and non-enzymatic, the redox imbalance between the production of free radicals and antioxidant capacity,  in biological systems that act against free radicals, and the impact of natural and synthetic products on the endogenous antioxidant defense system.

Dr. Ankush Prasad
Dr. Deepak Kumar Yadav
Dr. Pavel Pospíšil
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reactive oxygen species (ROS)
  • free radical biology
  • ROS in biology
  • antioxidant enzymes and defenses
  • ROS effects in developmental biology
  • oxidative stress
  • methods in free radical research

Published Papers (2 papers)

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Research

10 pages, 265 KiB  
Article
The Influence of Whole-Body Cryotherapy or Winter Swimming on the Activity of Antioxidant Enzymes
by Bartłomiej Ptaszek, Szymon Podsiadło, Olga Czerwińska-Ledwig, Aneta Teległów, Wanda Pilch and Ewa Sadowska-Krępa
Biology 2024, 13(5), 295; https://doi.org/10.3390/biology13050295 - 25 Apr 2024
Viewed by 204
Abstract
The aim of this study was to investigate the effect of a series of 20 whole-body cryotherapy sessions and 20 winter swimming sessions on the level of catalase, glutathione peroxidase and superoxide dismutase. The experimental group consisted of 60 people (30 people received [...] Read more.
The aim of this study was to investigate the effect of a series of 20 whole-body cryotherapy sessions and 20 winter swimming sessions on the level of catalase, glutathione peroxidase and superoxide dismutase. The experimental group consisted of 60 people (30 people received cryotherapy and 30 people swam in cold water). The control group—without intervention: 30 people. Each of the three groups was tested twice. Analyzing the changes in the examined indicators, a statistical increase of CAT was observed in men after the use of WBC, as well as an increase of SOD in women and a decrease of SOD in men after the winter swimming season. Regular WS does not seem to place an excessive burden on the body in terms of intensifying oxidative processes. WS sessions once a week can be recommended as an effective method of improving health by causing positive adaptive changes and strengthening the body’s antioxidant barrier. WBC may be used as an adjunct therapy in the treatment of diseases caused by oxidative stress, as it improves the body’s antioxidant capacity. Further research is needed to elucidate antioxidant mechanisms in humans and to determine the short- and long-term effects of exposure to WS and WBC. Full article
(This article belongs to the Special Issue Free Radicals in Biology and Medicine)
15 pages, 1866 KiB  
Article
Long Non-Coding RNAs in Hypoxia and Oxidative Stress: Novel Insights Investigating a Piglet Model of Perinatal Asphyxia
by Benedicte Grebstad Tune, Maria Melheim, Monica Åsegg-Atneosen, Baukje Dotinga, Ola Didrik Saugstad, Rønnaug Solberg and Lars Oliver Baumbusch
Biology 2023, 12(4), 549; https://doi.org/10.3390/biology12040549 - 04 Apr 2023
Viewed by 1372
Abstract
Birth asphyxia is the leading cause of death and disability in young children worldwide. Long non-coding RNAs (lncRNAs) may provide novel targets and intervention strategies due to their regulatory potential, as demonstrated in various diseases and conditions. We investigated cardinal lncRNAs involved in [...] Read more.
Birth asphyxia is the leading cause of death and disability in young children worldwide. Long non-coding RNAs (lncRNAs) may provide novel targets and intervention strategies due to their regulatory potential, as demonstrated in various diseases and conditions. We investigated cardinal lncRNAs involved in oxidative stress, hypoxia, apoptosis, and DNA damage using a piglet model of perinatal asphyxia. A total of 42 newborn piglets were randomized into 4 study arms: (1) hypoxia–normoxic reoxygenation, (2) hypoxia–3 min of hyperoxic reoxygenation, (3) hypoxia–30 min of hyperoxic reoxygenation, and (4) sham-operated controls. The expression of lncRNAs BDNF-AS, H19, MALAT1, ANRIL, TUG1, and PANDA, together with the related target genes VEGFA, BDNF, TP53, HIF1α, and TNFα, was assessed in the cortex, the hippocampus, the white matter, and the cerebellum using qPCR and Droplet Digital PCR. Exposure to hypoxia–reoxygenation significantly altered the transcription levels of BDNF-AS, H19, MALAT1, and ANRIL. BDNF-AS levels were significantly enhanced after both hypoxia and subsequent hyperoxic reoxygenation, 8% and 100% O2, respectively. Our observations suggest an emerging role for lncRNAs as part of the molecular response to hypoxia-induced damages during perinatal asphyxia. A better understanding of the regulatory properties of BDNF-AS and other lncRNAs may reveal novel targets and intervention strategies in the future. Full article
(This article belongs to the Special Issue Free Radicals in Biology and Medicine)
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