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Biology
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Metabolism of Hematopoietic Stem Cells during Development and Aging
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Metabolism of Hematopoietic Stem Cells during Development and Aging

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".

Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 4939

Special Issue Editor

Dr. Tasleem Arif

E-Mail Website1 Website2
Guest Editor
Department of Cell, Developmental & Regenerative Biology, Icahn School of Medicine, Mount Sinai, NY 10029, USA
Interests: cancer metabolism; mitochondria; hematopoiesis; hematopoietic stem cells; autophagy; lysosomes; mitochondrial aging; developmental biology; acute myeloid leukemia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the 1920s, Otto Warburg showed that cancer cells absorbed a large quantity of glucose to sustain their rapid metabolism. He further hypothesized that malignancies may be treated by regulating aerobic vs anaerobic glycolysis. Meanwhile, alterations in metabolism have been found to control cell signaling, gene expression, cellular destiny, and tissue function. Metabolic changes impede cellular differentiation and long-term destiny, and they play a crucial role in aging and cancer transformation. The focus of this Special Issue is on the metabolic control of self-renewal and differentiation and how dysregulation, aging, and malignant transformation may occur from disturbed metabolisms. This Special Issue will also include the following: how metabolites impact developmental decisions in hematopoietic stem cells; how mitochondrial and lysosomal function influence stem cell aging, metabolite epigenetic functions, and metabolite signaling roles across stem cells; and the effect of metabolic therapies in aging and diseases. The goal of this Special Issue is to increase collaboration across a variety of fields and, ultimately, to examine how metabolic pathway treatments might influence the aging process.

Dr. Tasleem Arif
Guest Editor

Manuscript Submission Information

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Keywords

  • hematopoietic stem cells
  • aging
  • metabolism
  • glucose metabolism
  • epigenetic dysregulation genomics
  • transcriptomics
  • proteomics
  • mitochondrial aging
  • autophagy
  • lysosomes
  • transcription factors

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Published Papers (1 paper)

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25 pages, 1641 KiB  
Review
Lysosomes and Their Role in Regulating the Metabolism of Hematopoietic Stem Cells
by Tasleem Arif
Biology 2022, 11(10), 1410; https://doi.org/10.3390/biology11101410 - 27 Sep 2022
Cited by 5 | Viewed by 4178
Abstract
Hematopoietic stem cells (HSCs) have the capacity to renew blood cells at all stages of life and are largely quiescent at a steady state. It is essential to understand the processes that govern quiescence in HSCs to enhance bone marrow transplantation. It is [...] Read more.
Hematopoietic stem cells (HSCs) have the capacity to renew blood cells at all stages of life and are largely quiescent at a steady state. It is essential to understand the processes that govern quiescence in HSCs to enhance bone marrow transplantation. It is hypothesized that in their quiescent state, HSCs primarily use glycolysis for energy production rather than mitochondrial oxidative phosphorylation (OXPHOS). In addition, the HSC switch from quiescence to activation occurs along a continuous developmental path that is driven by metabolism. Specifying the metabolic regulation pathway of HSC quiescence will provide insights into HSC homeostasis for therapeutic application. Therefore, understanding the metabolic demands of HSCs at a steady state is key to developing innovative hematological therapeutics. Lysosomes are the major degradative organelle in eukaryotic cells. Catabolic, anabolic, and lysosomal function abnormalities are connected to an expanding list of diseases. In recent years, lysosomes have emerged as control centers of cellular metabolism, particularly in HSC quiescence, and essential regulators of cell signaling have been found on the lysosomal membrane. In addition to autophagic processes, lysosomal activities have been shown to be crucial in sustaining quiescence by restricting HSCs access to a nutritional reserve essential for their activation into the cell cycle. Lysosomal activity may preserve HSC quiescence by altering glycolysis-mitochondrial biogenesis. The understanding of HSC metabolism has significantly expanded over the decade, revealing previously unknown requirements of HSCs in both their dividing (active) and quiescent states. Therefore, understanding the role of lysosomes in HSCs will allow for the development of innovative treatment methods based on HSCs to fight clonal hematopoiesis and HSC aging. Full article
(This article belongs to the Special Issue Metabolism of Hematopoietic Stem Cells during Development and Aging)
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