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Biomedicines
Special Issues
Theranostic Drug Delivery: Prospects and Problems 2.0
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Theranostic Drug Delivery: Prospects and Problems 2.0

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 2386

Special Issue Editor

Prof. Dr. M. R. Mozafari

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
Interests: nanobiotechnology; drug delivery; pharmaceutics; molecular biology; liposomes; drug targeting; cancer; pharmaceutical nanotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

After the success of the first Special Issue on "Theranostic Drug Delivery: Prospects and Problems", in which high-impact papers authored by eminent international scientists were published, we are now aiming to launch the second Special Issue on the topic. As an important aspect of modern medicine, the theranostic approach is the most advanced, scientifically based, and statistically approved therapeutic and diagnostic methodology. Applications in the diagnosis and treatment of viral diseases and different types of cancer are being developed worldwide. We invite innovative research papers and review articles reflecting the fields of in vitro diagnostics and prognostics as well as in vivo molecular therapeutics and molecular imaging. In addition, we welcome manuscripts on biosensors, image-guided therapy, translational medicine, personalized medicine, system biology, and a broad range of biomedical research, which can be applied to enhance theranostic applications.

Prof. Dr. M. R. Mozafari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • controlled release
  • diagnosis
  • drug carrier
  • drug delivery
  • drug targeting
  • encapsulation
  • nanotherapy
  • personalized medicine
  • theranostics

Published Papers (1 paper)

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Research

17 pages, 4663 KiB  
Article
Interaction of Epigallocatechin Gallate and Quercetin with Spike Glycoprotein (S-Glycoprotein) of SARS-CoV-2: In Silico Study
by Mehran Alavi, M. R. Mozafari, Saba Ghaemi, Morahem Ashengroph, Fatemeh Hasanzadeh Davarani and Mohammadreza Mohammadabadi
Biomedicines 2022, 10(12), 3074; https://doi.org/10.3390/biomedicines10123074 - 29 Nov 2022
Cited by 2 | Viewed by 1996
Abstract
Severe acute respiratory syndrome (SARS)-CoV-2 from the family Coronaviridae is the cause of the outbreak of severe pneumonia, known as coronavirus disease 2019 (COVID-19), which was first recognized in 2019. Various potential antiviral drugs have been presented to hinder SARS-CoV-2 or treat COVID-19 [...] Read more.
Severe acute respiratory syndrome (SARS)-CoV-2 from the family Coronaviridae is the cause of the outbreak of severe pneumonia, known as coronavirus disease 2019 (COVID-19), which was first recognized in 2019. Various potential antiviral drugs have been presented to hinder SARS-CoV-2 or treat COVID-19 disease. Side effects of these drugs are among the main complicated issues for patients. Natural compounds, specifically primary and secondary herbal metabolites, may be considered as alternative options to provide therapeutic activity and reduce cytotoxicity. Phenolic materials such as epigallocatechin gallate (EGCG, polyphenol) and quercetin have shown antibacterial, antifungal, antiviral, anticancer, and anti-inflammatory effects in vitro and in vivo. Therefore, in this study, molecular docking was applied to measure the docking property of epigallocatechin gallate and quercetin towards the transmembrane spike (S) glycoprotein of SARS-CoV-2. Results of the present study showed Vina scores of −9.9 and −8.3 obtained for EGCG and quercetin by CB-Dock. In the case of EGCG, four hydrogen bonds of OG1, OD2, O3, and O13 atoms interacted with the Threonine (THR778) and Aspartic acid (ASP867) amino acids of the spike glycoprotein (6VSB). According to these results, epigallocatechin gallate and quercetin can be considered potent therapeutic compounds for addressing viral diseases. Full article
(This article belongs to the Special Issue Theranostic Drug Delivery: Prospects and Problems 2.0)
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