From Bench to Bedside: Translational Breakthroughs in Castration-Resistant Prostate Cancer Research

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 931

Special Issue Editor


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Guest Editor
Pete Nelson Lab, Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, USA
Interests: castration-resistance prostate cancer; advanced prostate cancer; androgen receptor; androgen receptor cistrome; epigenetic therapy; lineage plasticity; translational research

Special Issue Information

Dear Colleagues,

This Special Issue, "From Bench to Bedside: Translational Breakthroughs in Castration-Resistant Prostate Cancer Research" , seeks to provide an overview of the significant strides made in CRPC. Prostate cancer is the second most diagnosed malignancy and the fifth leading cause of cancer death among men globally, underscoring the urgent need for advanced therapeutic strategies. Despite this grim statistic, the last decade has been witness to a revolution in prostate cancer treatment marked by rapid advances, e.g., second-generation androgen pathway inhibitors, and improved survival rates.

This Special Issue will present cutting-edge translational research that bridges experimental science and clinical application, focusing on the persistent challenge of CRPC. Contributions should detail the progress in this field, from identifying molecular targets in the lab to developing novel therapies that enhance patients' quality of life and survival. We welcome submissions detailing innovative diagnostic approaches, targeted therapies, immunotherapies, antibody–drug conjugates (ADCs), and strategies for overcoming drug resistance.

Researchers are invited to share their findings on the biology of CRPC, particularly new insights into its development and progression, and the translation of these findings into clinical practice. This Special Issue aims to be a testament to the collaborative efforts of scientists and clinicians who are turning the tide against prostate cancer, offering hope through their commitment to research that culminates in saving lives.

Dr. Wanting Han
Guest Editor

Manuscript Submission Information

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Keywords

  • prostate cancer
  • castration-resistance prostate cancer
  • CRPC
  • emerging therapies
  • translational breakthrough
  • therapeutic strategies
  • biomarker

Published Papers (1 paper)

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Research

12 pages, 1364 KiB  
Article
Bone Turnover Markers, n-Terminal Propeptide of Type I Procollagen and Tartrate-Resistant Acid Phosphatase Type 5b, for Predicting Castration Resistance in Prostate Cancer
by Hiroshi Kano, Kouji Izumi, Ryunosuke Nakagawa, Ren Toriumi, Shuhei Aoyama, Taiki Kamijima, Tomoyuki Makino, Renato Naito, Hiroaki Iwamoto, Hiroshi Yaegashi, Shohei Kawaguchi, Kazuyoshi Shigehara, Takahiro Nohara and Atsushi Mizokami
Biomedicines 2024, 12(2), 292; https://doi.org/10.3390/biomedicines12020292 - 26 Jan 2024
Cited by 1 | Viewed by 805
Abstract
Bone is a common site of prostate cancer metastasis. Bone turnover markers n-terminal propeptide of type I procollagen (P1NP) and tartrate-resistant acid phosphatase type 5b (TRACP-5b) are highly sensitive to bone remodeling activity. However, their prognostic significance as markers of prostate cancer is [...] Read more.
Bone is a common site of prostate cancer metastasis. Bone turnover markers n-terminal propeptide of type I procollagen (P1NP) and tartrate-resistant acid phosphatase type 5b (TRACP-5b) are highly sensitive to bone remodeling activity. However, their prognostic significance as markers of prostate cancer is unknown. This study retrospectively examined the usefulness of P1NP and TRACP-5b as prognostic biomarkers. Castration-resistant prostate cancer recurrence-free survival (CFS) was estimated using the Kaplan–Meier method. A predictive model for CFS was constructed using multivariate analysis. This study enrolled 255 patients diagnosed with prostate cancer at Kanazawa University Hospital. The median follow-up was 115.1 months. Patients with both high serum P1NP and TRACP-5b levels, defined as having a poor bone turnover category (BTC), had significantly shorter CFS. Multivariate analysis identified Gleason score, metastasis, and BTC poor as predictors for castration resistance in prostate cancer. Using these three factors, a prognostic model was established, categorizing patients into low-risk (no or one factor) and high-risk (two or three factors) groups. In the low-risk group, the median CFS was not reached, contrasting with 19.1 months in the high-risk group (hazard ratio, 32.23, p < 0.001). Combining P1NP and TRACP-5b may better predict castration resistance. Full article
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