Past, Present and Further Looking for Therapeutic Management of Pancreatic Ductal Adenocarcinoma
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 8333
Special Issue Editors
Interests: pancreatic cancer; periampullary tumors; ampullary carcinoma; distal cholangiocarcinoma; therapeutic targets; diagnostic molecular markers; predictive molecular markers; prognostic molecular markers; preclinical models; conventional and unconventional chemoterapeutic approaches; teragnostics
Special Issues, Collections and Topics in MDPI journals
Interests: pancreatic cancers; pancreatic ductal adenocarcinoma; IPMN; histopathology; primary cell cultures; molecular biology; molecular pathology; laser microdissection; miRNAs; oncomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pancreatic ductal adenocarcinoma (PDAC) still represents one of the cancers with the poorest prognosis. Currently, surgery remains the only curative treatment for PDAC, but the 5-year survival rate of resected patients is only about 20–25%. During the last decades, some improvements have been done in terms of chemotherapic treatment, with the development of specific multi-chemotherapic regimens (FOLFIRINOX, gemcitabine + nab-paclitaxel, PAX-G) that have improved oncological results if compared with historical adopted single chemotherapic agents (gemcitabine). Moreover, if historically, for resectable PDAC, the gold standard strategy was surgery followed by adjuvant therapy, currently the scenario is radically changing. More often, the growing idea is to perform neoadjuvant therapy followed by surgery and, eventually, adjuvant treatment. The rationale for this approach is the early management of micro-metastatic disease and to allow a better selection of patient candidates to surgery. Thus, the analyses of old, recent and upcoming molecular markers could change the landscape of clinical management of the PDAC. However, preclinical models of PDAC, including all different levels of models approaching PDAC, will be appreciated in order to show experimental attempts to validate the role of biomolecular markers and their affinity for chemotherapy. Indeed, other new frontiers of PDAC treatment, including phytotherapy and theragnostic molecules, are welcome.
This Special Issue aims to evaluate all the novel therapeutic approaches for the management of PDAC (resectable, borderline-resectable, locally advanced and metastatic disease): pre-clinical and clinical studies focusing on this topic will be included in this Special Issue.
Dr. Gennaro Nappo
Dr. Niccola Funel
Guest Editors
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Keywords
- pancreatic cancer
- pancreatic ductal adenocarcinoma
- treatment pancreatic cancer
- chemotherapy pancreatic cancer
- radiotherapy pancreatic cancer
- pancreatic cancer biology
- PDAC preclinical model
- biomolecular markers
- theragnostic molecules
- target therapy
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