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Special Issue Information

Dear Colleagues,

Gastrointestinal diseases involve various benign and malignant pathologies of a digestive tract as well as liver, biliary tract and pancreas. Their diagnostics and treatment is usually very challenging and requires an engagement of the multidisciplinary team including gastroenterologists, radiologists, oncologists and surgeons.The laboratory, imaging and endoscopic, non-invasive and invasive investigations are used in diagnostics of gastrointestinal diseases. Also, the management has got a wide spectrum: from observation and conservative treatment to invasive radiological, endoscopic and surgical procedures.Recently, both diagnostics and treatment of gastrointestinal diseases have been improved, including i.a. molecular laboratory tests, gastrointestinal endoscopy with artificial intelligence, targeted and immunological oncological therapy, as well as robotic surgery.

This Special Issue on “Gastrointestinal Disease: New Diagnostic and Therapeutic Approaches” will focus on new aspects regarding laboratory diagnostics as well as pharmacological, immunological, and targeted treatment of these diseases. We invite original research and review papers related to all novel aspects of diagnostics and treatment of gastrointestinal diseases.

Dr. Beata Jabłońska
Dr. Sławomir Mrowiec
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

inflammatory bowel disease
gastrointestinal tumor
gastrointestinal cancer
acute pancreatitis
chronic pancreatitis
pancreatic cyst
biliary cyst

Published Papers (2 papers)

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Editorial

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4 pages, 208 KiB

Open AccessEditorial

Gastrointestinal Disease: New Diagnostic and Therapeutic Approaches

by Beata Jabłońska and Sławomir Mrowiec

Biomedicines 2023, 11(5), 1420; https://doi.org/10.3390/biomedicines11051420 - 11 May 2023

Viewed by 1543

Abstract

Gastrointestinal diseases (GIDs) involve various benign and malignant pathologies of the digestive tract, as well as the liver, biliary tract, and pancreas [...] Full article

(This article belongs to the Special Issue Pancreatic, Liver, Biliary Tract and Intestinal Diseases: Pathogenesis, Diagnostics and Therapy)

Research

Jump to: Editorial

14 pages, 530 KiB

Open AccessArticle

Expression of Selected miRNAs in Undifferentiated Carcinoma with Osteoclast-like Giant Cells (UCOGC) of the Pancreas: Comparison with Poorly Differentiated Pancreatic Ductal Adenocarcinoma

by Alexey Popov, Jan Hrudka, Arpád Szabó, Martin Oliverius, Zdeněk Šubrt, Jana Vránová, Vanda Ciprová, Jana Moravcová and Václav Mandys

Biomedicines 2024, 12(5), 962; https://doi.org/10.3390/biomedicines12050962 - 26 Apr 2024

Viewed by 325

Abstract

Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas represents a rare subtype of pancreatic ductal adenocarcinoma (PDAC). Despite a distinct morphology and specific clinical behavior, UCOGCs exhibit unexpected similarities in regard to DNA mutational profiles with conventional PDAC. Treating pancreatic ductal adenocarcinoma is particularly challenging, with limited prospects for cure. As with many other malignant neoplasms, the exploration of microRNAs (miRNAs, miRs) in regulating the biological characteristics of pancreatic cancer is undergoing extensive investigation to enhance tumor diagnostics and unveil the therapeutic possibilities. Herein, we evaluated the expression of miR-21, -96, -148a, -155, -196a, -210, and -217 in UCOGCs and poorly differentiated (grade 3, G3) PDACs. The expression of miR-21, miR-155, and miR-210 in both UCOGCs and G3 PDACs was significantly upregulated compared to the levels in normal tissue, while the levels of miR-148a and miR-217 were downregulated. We did not find any significant differences between cancerous and normal tissues for the expression of miR-96 and miR-196a in G3 PDACs, whereas miR-196a was slightly, but significantly, downregulated in UCOGCs. On the other hand, we have not observed significant differences in the expression of the majority of miRNAs between UCOGC and G3 PDAC, with the exception of miR-155. UCOGC samples demonstrated lower mean levels of miR-155 in comparison with those in G3 PDACs. Full article

(This article belongs to the Special Issue Pancreatic, Liver, Biliary Tract and Intestinal Diseases: Pathogenesis, Diagnostics and Therapy)

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