The Cannabinoid System: Potential and Implications for Health and Disease?

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 2550

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Department of Psychiatry, Amsterdam UMC—University of Amsterdam, Amsterdam, The Netherlands
Interests: psychiatry; psychopharmacology; addiction; drugs of abuse; toxicity
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Dear Colleagues,

The cannabinoid system has increasingly attracted attention by the scientific and medical community in recent decades, since the compounds in cannabis and their biological targets are implicated in various processes of health and disease. Cannabis and its constituents (cannabinoids) have shown promise as therapeutics in cancer, inflammatory disease and multiple sclerosis. On the other hand, cannabinoids could also be beneficial for mental health, although there is not yet a scientific consensus on this subject. For instance, the main psychoactive compound, delta-9-tetrahydrocannabinol (THC), is both praised as therapeutic and scorned for its psychoactive properties, which may cause psychosis and depression. Cannabidiol (CBD), another cannabinoid, might alleviate the symptoms of mental illness. Many countries have recently adapted new legislation on cannabis, with many others to follow, and the therapeutic potential of this controversial plant to treat a plethora of health disorders is being investigated with new vigor. Therefore, we invite research groups and authors to publish new articles that shed further light on the cannabinoid system and its possible implications for health and disease.

Dr. Tibor Markus Brunt
Guest Editor

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Keywords

  • THC
  • CBD
  • psychoactive
  • disease
  • disorders
  • beneficial
  • therapeutic

Published Papers (1 paper)

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Review

39 pages, 1586 KiB  
Review
Exploring the Therapeutic Potential of Cannabinoid Receptor Antagonists in Inflammation, Diabetes Mellitus, and Obesity
by Alexandru Vasincu, Răzvan-Nicolae Rusu, Daniela-Carmen Ababei, Monica Neamțu, Oana Dana Arcan, Ioana Macadan, Sorin Beșchea Chiriac, Walther Bild and Veronica Bild
Biomedicines 2023, 11(6), 1667; https://doi.org/10.3390/biomedicines11061667 - 8 Jun 2023
Cited by 2 | Viewed by 2238
Abstract
Recently, research has greatly expanded the knowledge of the endocannabinoid system (ECS) and its involvement in several therapeutic applications. Cannabinoid receptors (CBRs) are present in nearly every mammalian tissue, performing a vital role in different physiological processes (neuronal development, immune modulation, energy homeostasis). [...] Read more.
Recently, research has greatly expanded the knowledge of the endocannabinoid system (ECS) and its involvement in several therapeutic applications. Cannabinoid receptors (CBRs) are present in nearly every mammalian tissue, performing a vital role in different physiological processes (neuronal development, immune modulation, energy homeostasis). The ECS has an essential role in metabolic control and lipid signaling, making it a potential target for managing conditions such as obesity and diabetes. Its malfunction is closely linked to these pathological conditions. Additionally, the immunomodulatory function of the ECS presents a promising avenue for developing new treatments for various types of acute and chronic inflammatory conditions. Preclinical investigations using peripherally restricted CBR antagonists that do not cross the BBB have shown promise for the treatment of obesity and metabolic diseases, highlighting the importance of continuing efforts to discover novel molecules with superior safety profiles. The purpose of this review is to examine the roles of CB1R and CB2Rs, as well as their antagonists, in relation to the above-mentioned disorders. Full article
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