Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.7
4.7
Journals
Biomedicines
Special Issues
Signaling of Protein Kinases in Development and Disease
share announcement

Signaling of Protein Kinases in Development and Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1241

Special Issue Editor

Dr. John Zheng Fu

E-Mail Website
Guest Editor
Department of Pharmacology, University of Virginia, Charlottesville, VA, USA
Interests: cell signaling of protein kinases; mechanism of ciliopathy

Special Issue Information

Dear Colleagues,

Protein kinases comprise one of the largest and most abundant gene families in humans and play a pivotal role in signal transduction during tissue development, patterning, and homeostasis through the phosphorylation and functional modulation of protein substrates. Both germ-line and somatic mutations in kinase genes have been associated with many human diseases. Protein kinases are the second most targeted group for drug development. Novel therapeutic strategies to target protein kinases and intervene in cell signaling are still limited due to our incomplete understanding of their signaling mechanisms.

This Special Issue welcomes both comprehensive reviews and original articles to highlight the recent progress in the discovery of new mechanisms by which protein kinases function and human mutations disrupt kinase signaling and impact signal transduction.

Dr. John Zheng Fu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • kinase
  • phosphorylation
  • signaling
  • mutation
  • mechanism
  • development
  • inhibitor
  • disease

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

14 pages, 2738 KiB  
Article
Farnesol Inhibits PI3 Kinase Signaling and Inflammatory Gene Expression in Primary Human Renal Epithelial Cells
by Aline Müller, Maria Lozoya, Xiaoying Chen, Volkmar Weissig and Mahtab Nourbakhsh
Biomedicines 2023, 11(12), 3322; https://doi.org/10.3390/biomedicines11123322 - 15 Dec 2023
Viewed by 928
Abstract
Chronic inflammation and elevated cytokine levels are closely associated with the progression of chronic kidney disease (CKD), which is responsible for the manifestation of numerous complications and mortality. In addition to conventional CKD therapies, the possibility of using natural compounds with anti-inflammatory potential [...] Read more.
Chronic inflammation and elevated cytokine levels are closely associated with the progression of chronic kidney disease (CKD), which is responsible for the manifestation of numerous complications and mortality. In addition to conventional CKD therapies, the possibility of using natural compounds with anti-inflammatory potential has attracted widespread attention in scientific research. This study aimed to study the potential anti-inflammatory effects of a natural oil compound, farnesol, in primary human renal proximal tubule epithelial cell (RPTEC) culture. Farnesol was encapsulated in lipid-based small unilamellar vesicles (SUVs) to overcome its insolubility in cell culture medium. The cell attachment of empty vesicles (SUVs) and farnesol-loaded vesicles (farnesol-SUVs) was examined using BODIPY, a fluorescent dye with hydrophobic properties. Next, we used multiple protein, RNA, and protein phosphorylation arrays to investigate the impact of farnesol on inflammatory signaling in RPTECs. The results indicated that farnesol inhibits TNF-α/IL-1β-induced phosphorylation of the PI3 kinase p85 subunit and subsequent transcriptional activation of the inflammatory genes TNFRSF9, CD27, TNFRSF8, DR6, FAS, IL-7, and CCL2. Therefore, farnesol may be a promising natural compound for treating CKD. Full article
(This article belongs to the Special Issue Signaling of Protein Kinases in Development and Disease)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop